Glutathione S Transferases And Drug Resistance
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Glutathione S Transferases And Drug Resistance
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Author : John D. Hayes
language : en
Publisher: Taylor & Francis Group
Release Date : 1990
Glutathione S Transferases And Drug Resistance written by John D. Hayes and has been published by Taylor & Francis Group this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Carcinogenesis categories.
The proceedings of the 3rd International GST Conference held at the Royal College of Physicians, Edinburgh, on 20-30 August 1989. The conference was divided into five sessions - enzymology, toxication, control of expression, drug resistance and clinical applications of GST.
Structure And Function Of Glutathione S Transferases
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Author : Kenneth D. Tew
language : en
Publisher: CRC Press
Release Date : 1993-08-26
Structure And Function Of Glutathione S Transferases written by Kenneth D. Tew and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-08-26 with Medical categories.
Structure and Function of Glutathione S-Transferases provides some of the latest information available on a variety of structural and functional components of glutathione S-transferases, a family of isozymes involved in many endogenous and exogenous functions in cells. Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements. X-ray crystallographic structures show detailed information on the structural aspects of these proteins. Metabolism of a number of carcinogens and drugs is covered in detail, and the role that these enzymes play in governing drug resistance at the preclinical and clinical levels is discussed. The book will be excellent for biochemists, pharmacologists, oncologists, experimental therapeutic specialists, and others interested in glutathione S-transferases.
Toxicology Of Glutathione Transferases
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Author : Yogesh C. Awasthi
language : en
Publisher: CRC Press
Release Date : 2006-07-27
Toxicology Of Glutathione Transferases written by Yogesh C. Awasthi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-27 with Medical categories.
Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in
Heterogeneous Expression In Human Tumors Of Anionic Glutathione S Transferase A Phase Ii Enzyme Associated With Multidrug Resistance
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Author :
language : en
Publisher:
Release Date : 1988
Heterogeneous Expression In Human Tumors Of Anionic Glutathione S Transferase A Phase Ii Enzyme Associated With Multidrug Resistance written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Cancer cells categories.
Mechanisms Of Drug Resistance In Neoplastic Cells
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Author : Paul V. Woolley
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Mechanisms Of Drug Resistance In Neoplastic Cells written by Paul V. Woolley and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.
Glutathione S Transferases
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Author : Gerard J. Mulder
language : en
Publisher: CRC Press
Release Date : 1996-05-23
Glutathione S Transferases written by Gerard J. Mulder and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05-23 with Science categories.
Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzyme.
Drug Resistance In Leukemia And Lymphoma Iii
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Author : G.J.L. Kaspers
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Drug Resistance In Leukemia And Lymphoma Iii written by G.J.L. Kaspers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cellular drug resistance is a major limitation to the success of chemotherapy of leu kemia and lymphoma. The importance of this has now been recognized by both clinicians and scientists. It is of utmost importance to bridge the gap between laboratory and clinic in this field of research. This is the main purpose of the series of International Symposia on Drug Resistance in Leukemia and Lymphoma. These are held every three years in Am sterdam, The Netherlands, since 1992. This book contains the proceedings of the third of these meetings, organised in 1998. The book covers all important aspects of drug resistance in leukemia and lymphoma, both in the form of extensive reviews as in manuscripts describing original data. General mechanisms of resistance are discussed, including the drug resistance related proteins p glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the role of glutathione and glutathione-S-transferases. Moreover, more drug type-specific mechanisms of resistance are a topic, such as for glucocorticoids and antifolates. Much in formation is provided on apoptosis and its regulators, and on the results of cell culture drug resistance assays. Several papers focus on the modulation or circumvention of drug resistance.
Glutathione Transferases And Gamma Glutamyl Transpeptidases
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Author : Helmut Sies
language : en
Publisher: Gulf Professional Publishing
Release Date : 2005-11-22
Glutathione Transferases And Gamma Glutamyl Transpeptidases written by Helmut Sies and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-22 with Science categories.
Focuses on particular aspects of the so-called Phase II of drug detoxication, which has important ramifications for endogenous metabolism and nutrition. This volume on glutathione transferases and gamma-glutamyl transpeptidases serves to bring together methods and concepts in a rapidly developing field of cell and systems biology.
Drug Resistance
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Author : William N. Hait
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Drug Resistance written by William N. Hait and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.
Glutathione S Transferases And Carcinogenesis
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Author : Timothy John Mantle
language : en
Publisher: Taylor & Francis Group
Release Date : 1987
Glutathione S Transferases And Carcinogenesis written by Timothy John Mantle and has been published by Taylor & Francis Group this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.