Structure And Function Of Glutathione S Transferases
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Structure And Function Of Glutathione S Transferases
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Author : Kenneth D. Tew
language : en
Publisher: CRC Press
Release Date : 1993-08-26
Structure And Function Of Glutathione S Transferases written by Kenneth D. Tew and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-08-26 with Medical categories.
Structure and Function of Glutathione S-Transferases provides some of the latest information available on a variety of structural and functional components of glutathione S-transferases, a family of isozymes involved in many endogenous and exogenous functions in cells. Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements. X-ray crystallographic structures show detailed information on the structural aspects of these proteins. Metabolism of a number of carcinogens and drugs is covered in detail, and the role that these enzymes play in governing drug resistance at the preclinical and clinical levels is discussed. The book will be excellent for biochemists, pharmacologists, oncologists, experimental therapeutic specialists, and others interested in glutathione S-transferases.
Glutathione S Transferases
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Author : Gerard J. Mulder
language : en
Publisher: CRC Press
Release Date : 1996-05-23
Glutathione S Transferases written by Gerard J. Mulder and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05-23 with Science categories.
Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzyme.
Glutathione S Transferases
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Author : Igor Azevedo Silva
language : en
Publisher:
Release Date : 2020
Glutathione S Transferases written by Igor Azevedo Silva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Glutathione transferase categories.
Glutathione S-transferase (GST) isoenzymes are an important superfamily of proteins that are present in homodimer or heterodimer structures. The isoenzymes included in this superfamily are involved in endobiotic and xenobiotic detoxification systems in animals, plants and microorganisms.This compilation focuses on the importance of functional aspects of polymorphic variants in different populations so the risk genotypes can be identified as indicators of disease susceptibility. Genetic studies will help to develop prognostic biomarkers for early prediction and risk assessment in patients, and enable clinicians to develop personalized treatment regimens. The authors examine the different kinds of reactive oxygen species and reactive species which act as carcinogens and cause damage to DNA, RNA, proteins and lipids, thereby resulting in human disease like bladder cancer.Also reviewed is the association of GST's common genetic variants with the development of infertility (failure to establish a clinical pregnancy after 12 months of regular, unprotected sexual intercourse) in women and in men.
Toxicology Of Glutathione Transferases
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Author : Yogesh C. Awasthi
language : en
Publisher: CRC Press
Release Date : 2006-07-27
Toxicology Of Glutathione Transferases written by Yogesh C. Awasthi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-27 with Medical categories.
Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in
Glutathione Transferases
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Author :
language : en
Publisher:
Release Date : 1992
Glutathione Transferases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Plant Glutathione Transferases Diverse Multi Tasking Enzymes With Yet To Be Discovered Functions
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Author : Jolán Csiszár
language : en
Publisher:
Release Date : 2019
Plant Glutathione Transferases Diverse Multi Tasking Enzymes With Yet To Be Discovered Functions written by Jolán Csiszár and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Glutathione Transferases And Gamma Glutamyl Transpeptidases
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Author : Helmut Sies
language : en
Publisher: Gulf Professional Publishing
Release Date : 2005-11-22
Glutathione Transferases And Gamma Glutamyl Transpeptidases written by Helmut Sies and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-22 with Science categories.
Focuses on particular aspects of the so-called Phase II of drug detoxication, which has important ramifications for endogenous metabolism and nutrition. This volume on glutathione transferases and gamma-glutamyl transpeptidases serves to bring together methods and concepts in a rapidly developing field of cell and systems biology.
Glutathione
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Author : Leopold Flohe
language : en
Publisher: CRC Press
Release Date : 2018-08-29
Glutathione written by Leopold Flohe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-29 with Medical categories.
This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets. Key selling features: Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery Chapter 11 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution (CC-BY) 4.0 license.
Glutathione In Plant Growth Development And Stress Tolerance
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Author : Mohammad Anwar Hossain
language : en
Publisher: Springer
Release Date : 2018-09-09
Glutathione In Plant Growth Development And Stress Tolerance written by Mohammad Anwar Hossain and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-09 with Science categories.
Glutathione (γ-glutamyl-cysteinyl-glycine) is a ubiquitously distributed sulfurcontaining antioxidant molecule that plays key roles in the regulation of plant growth, development, and abiotic and biotic stress tolerance. It is one of the most powerful low-molecular-weight thiols, which rapidly accumulates in plant cells under stress. Recent in-depth studies on glutathione homeostasis (biosynthesis, degradation, compartmentalization, transport, and redox turnover) and the roles of glutathione in cell proliferation and environmental stress tolerance have provided new insights for plant biologists to conduct research aimed at deciphering the mechanisms associated with glutathione-mediated plant growth and stress responses, as well as to develop stress-tolerant crop plants. Glutathione has also been suggested to be a potential regulator of epigenetic modifications, playing important roles in the regulation of genes involved in the responses of plants to changing environments. The dynamic relationship between reduced glutathione (GSH) and reactive oxygen species (ROS) has been well documented, and glutathione has been shown to participate in several cell signaling and metabolic processes, involving the synthesis of protein, the transport of amino acids, DNA repair, the control of cell division, and programmed cell death. Two genes, gamma-glutamylcysteine synthetase (GSH1) and glutathione synthetase (GSH2), are involved in GSH synthesis, and genetic manipulation of these genes can modulate cellular glutathione levels. Any fluctuations in cellular GSH and oxidized glutathione (GSSG) levels have profound effects on plant growth and development, as glutathione is associated with the regulation of the cell cycle, redox signaling, enzymatic activities, defense gene expression, systemic acquired resistance, xenobiotic detoxification, and biological nitrogen fixation. Being a major constituent of the glyoxalase system and ascorbate-glutathione cycle, GSH helps to control multiple abiotic and biotic stress signaling pathways through the regulation of ROS and methylglyoxal (MG) levels. In addition, glutathione metabolism has the potential to be genetically or biochemically manipulated to develop stress-tolerant and nutritionally improved crop plants. Although significant progress has been made in investigating the multiple roles of glutathione in abiotic and biotic stress tolerance, many aspects of glutathione-mediated stress responses require additional research. The main objective of this volume is to explore the diverse roles of glutathione in plants by providing basic, comprehensive, and in-depth molecular information for advanced students, scholars, teachers, and scientists interested in or already engaged in research that involves glutathione. Finally, this book will be a valuable resource for future glutathione-related research and can be considered as a textbook for graduate students and as a reference book for frontline researchers working on glutathione metabolism in relation to plant growth, development, stress responses, and stress tolerance.
Biological Reactive Intermediates Iii
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Author : James J. Kocsis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biological Reactive Intermediates Iii written by James J. Kocsis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.