Glycobiology Protocols
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Glycobiology Protocols
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Author : Inka Brockhausen
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Glycobiology Protocols written by Inka Brockhausen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
Glycobiology involves studies of complex carbohydrates and posttrans- tional modifications of proteins, and has become an important interdiscip- nary field encompassing chemistry, biochemistry, biology, physiology, and pathology. Although initial research was directed toward elucidation of the different carbohydrate structures and the enzymes synthesizing them, the field has now moved toward identifying the functions of carbohydrates. The pro- cols described in Glycobiology Protocols form a solid basis for investigations of glycan functions in health and disease. The cloning of many of the genes participating in glycosylation processes has helped to enhance our knowledge of how glycosylation is controlled, but has also added another dimension of complexity to the great heterogeneous variety of the structures of the oligos- charides of glycoproteins, proteoglycans, and glycolipids. A family of similar enzyme proteins exists for each glycosylation step. Glycosyltransferases are extremely specific for both the nucleotide sugar donor and the acceptor s- strate, but many other factors control sugar transfer, including the locali- tion and topology of enzymes, cofactors, possible chaperone proteins, and the availability of sugar acceptor substrates. The analysis of the intracellular organization of glycosylation and of the factors controlling the activities of the participating enzymes in the cell are important areas that need more research efforts. Another challenge for future research is to understand the glycodynamics of a cell, that is, how the cell responds to stimuli leading to biological and pathological changes in terms of alterations in glycosylation, and how this affects the biology of the cell.
Glycomics
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Author : Nicolle H. Packer
language : en
Publisher: Humana Press
Release Date : 2009-07-16
Glycomics written by Nicolle H. Packer and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-16 with Science categories.
Due to the significant contributions of carbohydrates to the functional diversity of the cell, the challenging study of the glycome has expanded beyond the research of carbohydrate experts and into the wider scope of the life sciences. To aid all scientists now delving into this vital subject area, Glycomics: Methods and Protocols collects a compendium of detailed laboratory protocols reflecting the increasing availability of sample preparation, chromatographic, electrophoretic, mass spectrometric, and bioinformatic tools specifically designed for the analysis of glycosylation. Leading researchers in the field address subjects such as glycoprotein and proteoglycan analysis, glycosylation structure determination, as well as various approaches to investigate the interaction between glycans and a variety of carbohydrate-recognizing proteins in order to aid exploration into the functional significance of the oligosaccharides. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glycomics: Methods and Protocols serves as a valuable guide for experimenters facing the challenges of glycan analysis in hope of providing further insights into the biology of cell-cell communication and interaction.
Experimental Glycoscience
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Author : Naoyuki Taniguchi
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-05
Experimental Glycoscience written by Naoyuki Taniguchi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-05 with Science categories.
The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure. In the post-genomic era, glycobiology is coming of age because more than half of proteins are glycosylated and the importance of sugar chains in various fields of life science research cannot be disregarded. Many scientists had not entered this area because glycobiology and glycoscience used to be considered difficult fields. This book, therefore, is presented much like a cookbook which can help scientists in fields other than glycobiology and glycoscience carry out research more easily.
Glycosyltransferases
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Author : Inka Brockhausen
language : en
Publisher: Humana
Release Date : 2016-08-23
Glycosyltransferases written by Inka Brockhausen and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
Glycosyltransferases (GTs) are essential for the biosynthesis of complex glycoconjugates and are powerful tools to study the functions of complex glycans in health, development and disease. Complex glycoconjugates, such as glycoproteins, proteoglycans and glycolipids, are assembled by GTs which synthesize specific linkages between sugars or sugars and protein. This is in contrast to the non-specific or less specific chemical glycation reactions, transglycosylation and reverse glycosylation reactions. Glycosyltransferases: Methods and Protocols contains a wide range of studies, methods and protocols which form a solid basis for investigations of the role and mechanisms, biology and pathology involving GTs. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Glycosyltransferases: Methods and Protocols is a vital contribution to glycobiology and glycopathology, and to applications of these enzymes in biotechnology and drug development. It will prove invaluable to students, postdoctoral fellows, and senior scientists carrying on research of GTs that has been intensified over the last years.
Experimental Glycoscience
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Author : Naoyuki Taniguchi
language : en
Publisher: Springer
Release Date : 2008-08-06
Experimental Glycoscience written by Naoyuki Taniguchi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-06 with Science categories.
The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure. In the post-genomic era, glycobiology is coming of age because more than half of proteins are glycosylated and the importance of sugar chains in various fields of life science research cannot be disregarded. Many scientists had not entered this area because glycobiology and glycoscience used to be considered difficult fields. This book, therefore, is presented much like a cookbook which can help scientists in fields other than glycobiology and glycoscience carry out research more easily.
Mass Spectrometry Of Glycoproteins
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Author : Jennifer J. Kohler
language : en
Publisher: Humana Press
Release Date : 2016-05-01
Mass Spectrometry Of Glycoproteins written by Jennifer J. Kohler and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-01 with Science categories.
This comprehensive new resource in Springer s Methods in Molecular Biology series features contributions from leading researchers who provide expert advice and reproducible, cutting-edge protocols for examining glycoproteins through mass spectrometry."
I
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-09-18
I written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-18 with Medical categories.
Chemical Glycobiology, Volume 597, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume, the first on chemical glycobiology, contains comprehensive chapters on the Discovery of New Glycosidases from Metagenomic Libraries, Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme, A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases, Directed evolution of glycopeptides using mRNA display, Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars, and Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates. Readers will find the latest information on this developing area of research, as reported by leaders in the field. Presents an updated volume in this regular series Covers research on chemical glycobiology
Glycobiology
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-10-25
Glycobiology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-25 with Science categories.
In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers’ own research efforts Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry
Glycobiology
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Author : Minoru Fukuda
language : en
Publisher: IRL Press
Release Date : 1993
Glycobiology written by Minoru Fukuda and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Glycoconjugates categories.
The interest in the carbohydrates of glycoproteins has greatly intensified in the past few years. The recent development of recombinant glycoproteins for therapeutic purposes necessitates the understanding of the structure-function relationship in glycoproteins. Knowledge of the biological roles of glycoproteins has significantly expanded. For instance, it is now known that carbohydrate-protein interaction is one of the most critical events in leukocyte-endothelial cell interaction. Such developments in biology and medicine require an updated methodology that aims at the basic understanding of the structure and biosynthesis of glycoproteins. In this book, the chapters are assembled to provide basic background and methods in order to allow one to analyze the structures of glycoproteins. The subjects covered include isolation, fractionation, and structural characterization of typical glycoproteins, such as those containing N-glycans and O-glycans. The book also covers the phosphatidylinositol anchor, a new type of glycosylation to attach proteins to membranes.
Introduction To Glycobiology
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Author : Maureen E. Taylor
language : en
Publisher: Oxford University Press, USA
Release Date : 2011-04-21
Introduction To Glycobiology written by Maureen E. Taylor and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-21 with Medical categories.
Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.