Gout And Uric Acid Metabolism
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Gout And Uric Acid Metabolism
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Author : John Harold Talbott
language : en
Publisher: Thieme Medical Publishers
Release Date : 1976
Gout And Uric Acid Metabolism written by John Harold Talbott and has been published by Thieme Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medical categories.
Purine Metabolism In Man
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Author : Oded Sperling
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Purine Metabolism In Man written by Oded Sperling and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication.
Purine Metabolism In Man
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Author : Oded Sperling
language : en
Publisher: Springer
Release Date : 1974-03
Purine Metabolism In Man written by Oded Sperling and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974-03 with Medical categories.
Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication.
Uric Acid
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Author : Francis H. McCrudden
language : en
Publisher:
Release Date : 1905
Uric Acid written by Francis H. McCrudden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1905 with Science categories.
Uric Acid
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Author : W.N. Kelley
language : en
Publisher: Springer
Release Date : 2012-01-05
Uric Acid written by W.N. Kelley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-05 with Medical categories.
Uric acid has attracted the attention of scientists from a broad spectrum of disciplines, and in recent years dramatic progress has occurred within many of these disciplines. This volume is designed to fill void in the field. Major works in the past five years have provided comprehensive reviews of disorders of uric acid metabolism for the clinical (1-3) as well as short reports of recent progress for the interested scholar (4, 5). In Uric Acid the reader will find extensive reviews of relevant topics selected largely by virtue of recent progress in the field and written by those who, to a considerable extent, qre responsible for that progress. Seven chapters are dedicated to a description of uric acid synthesis, its control, diseases resulting from aberrations in the pathway, and effects of intermediates and end products of this pathway on other metabolic processes. The next five chapters describe our current understanding of the mechanisms by which uric acid is elimi nated by the organism. Then seven chapters review the factors responsible for the human "disease" produced by uric acid in the joints and kidneys. The final four chapters provide a summary of therapeutic approaches to control gout, the most important disease caused per se by uric acid.
Purine Metabolism In Man Ii
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Author : Mathias M. Muller
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Purine Metabolism In Man Ii written by Mathias M. Muller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyl transferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Uric Acid
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Author : Francis Henry McCrudden
language : en
Publisher:
Release Date : 1905
Uric Acid written by Francis Henry McCrudden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1905 with Gout categories.
Purine Metabolism In Man Ii
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Author : Mathias M. Muller
language : en
Publisher: Springer
Release Date : 2012-12-27
Purine Metabolism In Man Ii written by Mathias M. Muller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-27 with Science categories.
The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate in such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyltransferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Purine Metabolism In Man Biochemistry And Pharmacology Of Uric Acid Metabolism
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Author :
language : en
Publisher:
Release Date : 1974
Purine Metabolism In Man Biochemistry And Pharmacology Of Uric Acid Metabolism written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with categories.
Purine Metabolism In Man Ii
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Author : Mathias M Muller
language : en
Publisher: Springer
Release Date : 2014-01-15
Purine Metabolism In Man Ii written by Mathias M Muller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.