Heat Shock Proteins And Myocardial Protection
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Heat Shock Proteins In Myocardial Protection
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Author : Rakesh C. Kukreja
language : en
Publisher: CRC Press
Release Date : 2000-08-01
Heat Shock Proteins In Myocardial Protection written by Rakesh C. Kukreja and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-01 with Science categories.
Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of "reperfusion injury". Therefore the salvage of additional myocardium is highly desirable. Over a decade ago, it was shown that whole body heat shock activated a powerful endogenous protective mechanism that significantly improved myocardial salvage following prolonged ischemia and reperfusion injury in the heart. A characteristic feature of this heat shock response was the expression of a family of proteins known as heat shock proteins. Many of these proteins function as molecular chaperones, helping to refold proteins denatured as a consequence of lethal injuries and facilitating the synthesis of new proteins to replace those irreparably damaged. Altered expression of these proteins has been extensively documented in association with a diverse array of diseases such as ischemia and perfusion injury, cardiac hypertrophy, fever, inflammation, metabolic diseases, infection, cell and tissue trauma, aging, and cancer. Interestingly, some studies have now shown a direct correlation of the heat shock proteins produced and the degree of myocardial protection. This book is a thorough description of the current state of knowledge of the mechanisms of heat shock proteins induced cardiac protection at the cellular and molecular level, the controversies in this growing field and the potential of treating ischemic heart disease with overexpression of heat shock proteins in patients. The book will be especially useful for investigators interested in studying tissue injury and its protection with the overexpression of heat shock proteins.
Heat Shock Proteins In Myocardial Protection
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Author :
language : en
Publisher:
Release Date : 2000
Heat Shock Proteins In Myocardial Protection written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of "reperfusion injury."
Heat Shock Proteins And Myocardial Protection
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Author : Jiang Chang
language : en
Publisher:
Release Date : 1999
Heat Shock Proteins And Myocardial Protection written by Jiang Chang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Heat Shock Proteins And The Cardiovascular System
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Author : A.A. Knowlton
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Heat Shock Proteins And The Cardiovascular System written by A.A. Knowlton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Heat shock proteins (HSP) were originally described in heat-shocked drosophila by Ritossa in the early 1960's. In the last 5 years it has become apparent that these heat shock proteins have important functions both in the normal cell and in the stressed cell. These proteins constitute an endogenous protective system; mutations in the heat shock proteins can be lethal, and there are no known organisms without heat shock proteins. The first observations on heat shock proteins and the heart were made in the 1980's and interest in these proteins increased over the decade. In the last few years there has been an exponential growth in number of papers published on heat shock proteins and the heart. Heat shock proteins have been implicated in a number of cardiovascular research areas including ischemia, hypertrophy, aging, and atherosclerosis, and this list is growmg. The purpose of this volume is to give an overview of our current understanding of the heat shock proteins in the cardiovascular system, and to summarize the approaches to the study of heat shock proteins in the heart. This volume assembles results from a number of different cardiovascular fields. and provides a comprehensive review of heat shock proteins in the cardiovascular system.
Insulin Regulates Myocardial Protection And Heat Shock Proteins Through Multiple Signaling Pathways
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Author : Gefeng Li
language : en
Publisher:
Release Date : 2007
Insulin Regulates Myocardial Protection And Heat Shock Proteins Through Multiple Signaling Pathways written by Gefeng Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Heart categories.
Myocardial Protection By Heat Stress
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Author : Erin Elizabeth Flaherty
language : en
Publisher:
Release Date : 1996
Myocardial Protection By Heat Stress written by Erin Elizabeth Flaherty and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Myocardial Preservation Preconditioning And Adaptation
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Author : Dipak Kumar Das
language : en
Publisher:
Release Date : 1996
Myocardial Preservation Preconditioning And Adaptation written by Dipak Kumar Das and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
In this volume, basic scientists, cardiologists and cardiac surgeons discuss all that is known about preconditioning/adaptation and how this state-of-the-art technique compares with conventional techniques of myocardial preservation, unveiling its mechanism of protection and potential clinical application.
Small Heat Shock Proteins And Protection Against Cardiac Ischemic Damage
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Author : Jody L. Martin
language : en
Publisher:
Release Date : 1997
Small Heat Shock Proteins And Protection Against Cardiac Ischemic Damage written by Jody L. Martin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
The Role Of Heat Shock Proteins Hsp70 And Hsp27 In Protection Against Ischemic Injury In The Myocardium And Cerebral Cortex
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Author : Jean-Christophe Leon Plumier
language : en
Publisher:
Release Date : 1996
The Role Of Heat Shock Proteins Hsp70 And Hsp27 In Protection Against Ischemic Injury In The Myocardium And Cerebral Cortex written by Jean-Christophe Leon Plumier and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Copia
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Author :
language : en
Publisher:
Release Date : 1807
Copia written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1807 with categories.