Myocardial Preservation Preconditioning And Adaptation
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Myocardial Preservation Preconditioning And Adaptation
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Author : Dipak Kumar Das
language : en
Publisher:
Release Date : 1996
Myocardial Preservation Preconditioning And Adaptation written by Dipak Kumar Das and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
In this volume, basic scientists, cardiologists and cardiac surgeons discuss all that is known about preconditioning/adaptation and how this state-of-the-art technique compares with conventional techniques of myocardial preservation, unveiling its mechanism of protection and potential clinical application.
Delayed Preconditioning And Adaptive Cardioprotection
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Author : G.F. Baxter
language : en
Publisher: Springer
Release Date : 2012-10-12
Delayed Preconditioning And Adaptive Cardioprotection written by G.F. Baxter and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-12 with Medical categories.
Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window' of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.
Myocardial Preservation And Cellular Adaptation
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Author : D.K. Das
language : en
Publisher: Elsevier
Release Date : 1998-12-18
Myocardial Preservation And Cellular Adaptation written by D.K. Das and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-12-18 with Science categories.
Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses. The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases. Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.
Myocardial Preconditioning
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Author : Cherry L. Wainwright
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-22
Myocardial Preconditioning written by Cherry L. Wainwright and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-22 with Science categories.
This book is about the unique ability of the heart to protect itself against the serious consequences of an abrupt reduction in blood flow to the myocardium - a phenomenon which is switched on by stress and termed myocardial preconditioning. This volume describes the main features and characteristics of preconditioning, with respect to the time-course of the protective effect of the phenomenon (first and second windows) and the different sequelae of myocardial ischaemia against which it protects, such as myocardial injury, arrhythmias and contractile dysfunction. The proposed mechanisms underlying the fascinating form of cardioprotection are discussed. Among these are the role of endogenous labile mediators, receptor-linked G proteins, ATP-sensitive potassium channels and protein kinase C activation.
Adaptive Protection Of The Heart
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Author : Felix Z. Meerson
language : en
Publisher: CRC Press
Release Date : 1990-11-21
Adaptive Protection Of The Heart written by Felix Z. Meerson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-11-21 with Medical categories.
This book explores the possibilities of protecting the heart against stress and ischemia through adaptation to intermittent hypoxia or to mild, nondamaging stress exposure. These possibilities are based on studies that show an increase in the potency and efficiency of stress-limiting systems when subjected to repeated stress actions, adaptation to high altitude hypoxia, or adaptation to increased physical loads. Any stress reaction is coupled with an activation of central and local stress-limiting systems, such as GABA-ergic, opioidergic, and serotonergic systems in the brain, as well as antioxidants, prostaglandins, and adenosine in executory organs. The book also presents the use of metabolites of stress-limiting systems rather than adaptation as a means to prevent cardiac arrythmias. It also discusses genetically determined deficiencies of stress-limiting systems and their role in the etiology of stress-induced diseases. Cardiologists and researchers studying stress and its effect on cardiovascular systems will find this book extremely useful.
Myocardial Protection Against Global Ischaemia By Preconditioning
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Author :
language : en
Publisher:
Release Date : 1997
Myocardial Protection Against Global Ischaemia By Preconditioning written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Cardiac Ischemia From Injury To Protection
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Author : Bohuslav Ost'ádal
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Cardiac Ischemia From Injury To Protection written by Bohuslav Ost'ádal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
Cardiac Ischemia: From Injury to Protection has been divided into six parts. The first part describes the differences between hypoxia and ischemia, animal models, the effects of ischemia on myocardial function and metabolism, and the electrophysiological consequences of ischemia. The second part deals with the mechanisms of cardiomyocyte death in ischemia, structural aspects of irreversible ischemic injury, necrosis and apoptosis of cardiac cells, the role of calcium, and the concept of calcium antagonism. The third chapter is a brief description of reperfusion injury, its clinical relevance, and possible prevention. The fourth part summarizes changes in myocardial vasculature during ischemia and reperfusion. The fifth part is the survey of two main possibilities for increasing cardiac resistance to ischemia and hypoxia, i.e. long-lasting adaptation to chronic hypoxia and short-lasting preconditioning. The last part of the book deals with comparative and ontogenetic aspects of cardiac sensitivity to oxygen deprivation; this chapter also summarizes the ontogenetic differences and limitations in endogenous and exogenous protection of the ischemic/hypoxic heart.
Ischaemia
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Author : M. Marber
language : en
Publisher: BIOS Scientific Publishers
Release Date : 1996-07-01
Ischaemia written by M. Marber and has been published by BIOS Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-01 with Science categories.
Most research on myocardial protection is now focused on ischaemic preconditioning. This book is a unique collection of articles by researchers at the cutting edge of preconditioning research. Using a multidisciplinary approach, it presents information on the mechanisms of preconditioning and examines how these mechanisms are relevant to the human heart.
Myocardial Ischemia And Preconditioning
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Author : Naranjan S. Dhalla
language : en
Publisher: Springer
Release Date : 2012-11-01
Myocardial Ischemia And Preconditioning written by Naranjan S. Dhalla and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-01 with Medical categories.
Current evidence suggests that the ischemic preconditioning response is a multi-factorial process consisting of an initial early trigger, an intermediate mediator, and an end effector. Each of these steps in is now its own intense area of investigation. The need to render the heart ischemic for a brief period to invoke the preconditioning response is currently the major factor limiting clinical application of this powerful cardioprotective strategy. Recent research efforts have utilized brief exposures to pharmacological agents, in lieu of a brief preconditioning ischemia, to trigger/mimic the ischemic preconditioning-induced response. The World Heart Congress held in Winnipeg in July 2001 provided a forum for the presentation of new insights into the basic mechanisms of ischemia and reperfusion injury, as well as novel strategies to protect the heart from cell death, ventricular arrhythmias, and contractile dysfunction. Many pioneers in the fields of ischemia-reperfusion injury and preconditioning-induced protection presented there and the chapters in this book represent selected papers from these symposia.
Myocardial Protection By Ischaemic Preconditioning
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Author : David Michael Walker
language : en
Publisher:
Release Date : 1995
Myocardial Protection By Ischaemic Preconditioning written by David Michael Walker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.