Histocompatibility Antigens

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Histocompatibility Antigens

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Author : B. Parham
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Histocompatibility Antigens written by B. Parham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.

The Major Histocompatibility Complex (MHC) was discovered as a con sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.

Genetics Of Human Histocompatibility Antigens And Their Relation To Disease

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Author : E. Thorsby
language : en
Publisher: Ardent Media
Release Date : 1973

Genetics Of Human Histocompatibility Antigens And Their Relation To Disease written by E. Thorsby and has been published by Ardent Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Medical categories.

Histocompatibility Testing

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Author : Jeffrey L Bidwell
language : en
Publisher: World Scientific
Release Date : 2000-03-08

Histocompatibility Testing written by Jeffrey L Bidwell and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-08 with Medical categories.

This invaluable book provides comprehensive coverage of contemporary serological, cellular and molecular methodologies in histocompatibility testing, and their application to human organ transplantation and transfusion. The contributors are internationally respected authorities in histocompatibility and immunogenetics, and are closely involved in the development or application of state-of-the-art technologies. The first three sections of the book are primarily intended for use as a bench manual for histocompatibility testers, immunologists and immunogeneticists; the fourth and fifth sections, on selection of donors and statistical methods, will further assist medical practitioners involved in clinical transplantation and its outcome. The final section of the book reviews the genetics and clinical relevance of minor histocompatibility antigens. Contents: Foreword:HLA Polymorphism: Origin and Maintenance (W F Bodmer)Introduction:Immune Recognition and the MHC (P Travers)Antibody-Based Histocompatibility Testing:HLA Typing by Alloantibodies and Monoclonal Antibodies (G M Th Schreuder)Screening for HLA-Specific Antibodies (C Brown & C Navarrete)Detection of Soluble HLA (V Rebmann & H Grosse-Wilde)Crossmatching by Lymphocytotoxicity and Flow Cytometry (S Martin & A Harmer)DNA-Based Histocompatibility Testing:PCR-SSP Typing (M Bunce)PCR-SSOP Typing (D Middleton)Sequencing-Based Typing (J Ross)DNA Conformational Analysis (J R Argüello & J A Madrigal)Microsatellite Typing (A Cambon-Thomsen et al.)On-Line HLA Sequence Alignments (G J Laundy & J L Bidwell)Cell-Based Histocompatibility Testing:Cell-Based Histocompatibility Testing (E Kaminski)Donor Selection:Allocation of Solid Organs for Transplantation (P A Dyer & S Sheldon)Selection of Haemopoietic Stem Cell Donors for Transplantation (A Green)Selection of Platelet Donors and Provision of HLA-Matched Platelets (J Harrison & C Navarrete)Statistical Methods:Population Genetics of the Human Major Histocompatibility Complex (R F Schipper et al.)Survival Analysis in Solid Organ Transplantation (P A Dyer)Survival Analysis in Bone Marrow Transplantation (S Richards)HLA and Disease Association: Statistical Considerations(J H Barrett et al.)Minor Histocompatibility Antigens:Minor Histocompatibility Antigens (E Simpson) Readership: Researchers in immunology, histopathology, cell biology and genetics, surgeons and workers in blood transfusion. Keywords:Immunology;Genetics;Immunogenetics;Transplantation;Histocompatibility;Tissue Typing;Human Leucocyte Antigens, HLA;Major Histocompatibility Complex, MHC;Laboratory Methods

Cell Biology Of The Major Histocompatibility Complex

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Author : Benvenuto Pernis
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Cell Biology Of The Major Histocompatibility Complex written by Benvenuto Pernis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Health & Fitness categories.

Cell Biology of the Major Histocompatibility Complex documents the proceedings of a symposium on ""Cell Biology of the Major Histocompatibility Complex"" held at Arden House on the Harriman Campus of Columbia University from June 8 -10, 1984. The meeting was the ninth of the P & S Biomedical Sciences Symposia. The book is organized into five parts. Part I on the structure of MHC molecules includes papers on human histocompatibility antigens; the cloning of human MHC; and organization of the genes of the H-2 complex. Part II on alternate forms of MHC molecules includes studies on the expression of a secreted form of the MHC class I antigen and alternative splicing in the H-2 multigene family. Part III deals with MHC biosynthesis, intracellular transport, and membrane expression. It includes studies on the manipulation of glycans on antigens of the MHC and dynamics of MHC molecules in lymphoid cells. Part IV on homologues of class I MHC molecules covers topics such as Tla expression in normal and malignant cells and the Qa series of antigens. Part V on the association of MHC with antigens includes studies such as histocompatibility molecules as immune response gene products and molecular nature of T-cell recognition of antigen.

Minor Histocompatibility Antigens

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Author : Derry Roopenian
language : en
Publisher: CRC Press
Release Date : 1999-08-01

Minor Histocompatibility Antigens written by Derry Roopenian and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-01 with Science categories.

With the widespread application of solid tissue and bone marrow transplantation as a treatment for an array of life threatening disorders, there is a pressing need for clinicians and experimentalists to understand the basis of immunological rejection of tissue transplants. While much previous work focuses on characterization of antigens encoded by

Current Trends In Histocompatibility

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Author : Ralph Reisfeld
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Current Trends In Histocompatibility written by Ralph Reisfeld and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.

Information about histocompatibility antigens is expanding so rapidly that it is difficult to remain abreast of aB advances. In these volumes, we have made an effort to bring together the most current work on topics that have generated most of the re cent advances and discussions. We have asked each author to present and interpret his most current work, and we have judiciously refrained from imposing our own prejudices and viewpoints. Although there is obvious overlap in some individual topics, we have encouraged this to provide the reader with as many different and some times opposing viewpoints as possible. This approach will, we liope, give a broad overview of current ideas in the field. We wish to thank all contributors for their timely and exciting manu scripts, and we sincerely hope that the reader will benefit from these volumes. R. A. Reisfeld S. Ferrone La Jolla ix Contents I. Serology and Genetics Chapter 1 Studies of HLA-DR Antigens by Complement Fixation Jacques M. Colombani, Laurent Degos, Virginia Lepage, Helene Dastot, Muriel Reboul, and Pierre Lethielleux 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Material and Methods. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Results and Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3. 1. Screening for Anti-HLA-DR Complement-Fixing Sera . . . . . . . . 4 3. 2. Expression of HLA-A, -B and -DR Antigens on Peripheral Blood Lymphocytes during Phytohemagglutinin Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3. 3. Expression of HLA-A, -B and -DR Antigens on Peripheral Blood Lymphocytes during Concanavalin A Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 4.

Molecular And Cellular Biology Of Histocompatibility Antigens

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Author :
language : en
Publisher:
Release Date : 1987

Molecular And Cellular Biology Of Histocompatibility Antigens written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Histocompatibility antigens categories.

Histocompatibility

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Author : George Snell
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Histocompatibility written by George Snell and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.

Histocampatibility covers the genetic, immunologic, and the chemical studies on allograft rejection process. The book is composed of 13 chapters that describe how these studies relate to medicine, organ transplantation in man, basic immunology, cell membrane structures, and cancer research. After briefly dealing with the early studies on isografts and allografts in laboratory animals, the book describes the histogenetic methods of gene manipulation and transplantation that permit identification of individual histocompatibility loci. The following chapter examines the significance of congenic resistant lines in determining the diversity of histocompatibility loci and allele and immune response genes. Other chapters present immunogenetic and serological methods, as well as the applications of these methods in studying alloantigens and H-2 complex loci and of immunogenetic methods to human. The book also discusses the practical implication of HLA immunogenetics in organ transplantation and describes the biochemical, immunochemical, and dynamic properties of alloantigens. A chapter discusses the associations between HLA system and disease and the various mechanisms that have been suggested to explain these associations. The last chapter focuses on allograft reaction and on established facts of cellular immunity. This book is a valuable source of information for researchers in the fields of medicine, organ transplantation in man, basic immunology, cell membrane structures, and cancer.

Histocompatibility Antigens Advances In Research And Application 2012 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26

Histocompatibility Antigens Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.

Histocompatibility Antigens—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Histocompatibility Antigens in a compact format. The editors have built Histocompatibility Antigens—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Histocompatibility Antigens in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Histocompatibility Antigens—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Hla Complex In Biology And Medicine

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Author : Narinder K Mehra
language : en
Publisher: Boydell & Brewer Ltd
Release Date : 2010-11-26

The Hla Complex In Biology And Medicine written by Narinder K Mehra and has been published by Boydell & Brewer Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-26 with Medical categories.

A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.