Histone Deacetylase Inhibitors Hdis
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Histone Deacetylase Inhibitors Hdis
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Author : Beverly D. Carson
language : en
Publisher: Nova Science Publishers
Release Date : 2015-05-07
Histone Deacetylase Inhibitors Hdis written by Beverly D. Carson and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-07 with HEALTH & FITNESS categories.
Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyze the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.
Histone Deacetylase Inhibitors Hdis
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Author : Beverly D. Carson
language : en
Publisher: Nova Science Publishers
Release Date : 2015
Histone Deacetylase Inhibitors Hdis written by Beverly D. Carson and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Cancer categories.
Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.
Histone Deacetylase Inhibitors As Cancer Therapeutics
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Histone Deacetylase Inhibitors As Cancer Therapeutics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Medical categories.
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics." Provides invaluable information on the exciting and fast-moving field of cancer research This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics" Outstanding and original reviews
Cancer Immunotherapy
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Author : Eva Sahakian
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-06-04
Cancer Immunotherapy written by Eva Sahakian and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-04 with Medical categories.
Histone deacetylase inhibitors (HDI) have been largely known for their ability to induce cell cycle arrest and apoptosis of tumor cells, effects that have translated into clinically significant antitumor activity against certain malignancies. In addition, there is now increasing evidence that HDIs are also endowed with immunoregulatory properties. Interestingly, while some reports have highlighted the anti-inflammatory effects of these compounds, others have shown pro-inflammatory effects triggered by HDIs in in vitro and in vivo studies. Known targets for HDIs are histone deacetylases (HDACs), enzymes that are recruited to gene promoters where they regulate transcription through histone modifications. Some HDACs, however, can also deacetylate nonhistone proteins, indicating that the role of HDACs in cell biology goes beyond their initial described effects on histones and encompasses now more complex regulatory functions. This complexity, along with the fact that most of the HDI currently in use are pan-HDI (multiple HDAC targets), might explain the divergent immunoregulatory effects of these compounds. Given this conundrum, in this chapter we have summarized the current understanding of the expression/function of specific HDACs in immune cells, knowledge that is providing important insights into their role in immunobiology and also paving the way for the development of more selective and potentially less toxic epigenetic-based approaches to effectively harness antitumor immune responses.
Histone Deacetylase Inhibitors Epidrugs For Neurological Disorders
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Author : Shabir Ahmad Ganai
language : en
Publisher:
Release Date : 2019
Histone Deacetylase Inhibitors Epidrugs For Neurological Disorders written by Shabir Ahmad Ganai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Biochemistry categories.
This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors' therapeutic efficacy against various neurological complications.
Histone Deacetylases
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Author : Sibaji Sarkar
language : en
Publisher: Humana
Release Date : 2016-06-01
Histone Deacetylases written by Sibaji Sarkar and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-01 with Science categories.
This volume provides different methodologies for all classes of histone deacetylases, which includes detailed procedures on Class I and II histone deacetylase inhibitors, SIRT inhibitors, and bromodomain inhibitors. Histone Deacetylases: Methods and Protocols is divided into four sections: Sections A and B describe methodologies used to detect the activity, function, or chromatin location of HDACs 1 through 11, with Section A discussing Class I and Section B discussing class II histone deacetylases; Section C focuses on the methodologies for cloning and characterizing the acetylation of SIRTs 1 through 7; and Section D describes methods related to histone deacetylase inhibitors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Histone Deacetylases: Methods and Protocols, is a valuable resource for investigators working on epigenetics, molecular biology, and genetics.
Epigenetic Therapy With Histone Deacetylase Inhibitors Implications For Cancer Treatment
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Author : Christiane Pienna Soares
language : en
Publisher: Frontiers Media SA
Release Date : 2021-06-02
Epigenetic Therapy With Histone Deacetylase Inhibitors Implications For Cancer Treatment written by Christiane Pienna Soares and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Science categories.
Enzyme Inhibitors Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Enzyme Inhibitors Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
Enzyme Inhibitors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Enzyme Inhibitors. The editors have built Enzyme Inhibitors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Enzyme Inhibitors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Enzyme Inhibitors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Prostate Cancer
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Author : Chawnshang Chang
language : en
Publisher: World Scientific
Release Date : 2005
Prostate Cancer written by Chawnshang Chang and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
Prostate cancer is the second leading cause of death in men and its progression is highly dependent on androgens and androgen receptors. However, even with treatment, eventually most prostate cancers progress. Studies of the mechanisms behind this progression leads to advances in treatments for androgen-related diseases.
Cancer Chemotherapy And Biotherapy
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Author : Bruce A. Chabner
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2011-12-07
Cancer Chemotherapy And Biotherapy written by Bruce A. Chabner and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-07 with Medical categories.
Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.