Histone Deacetylases
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Histone Deacetylases The Biology And Clinical Implication
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Author : Tso-Pang Yao
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-08-31
Histone Deacetylases The Biology And Clinical Implication written by Tso-Pang Yao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-31 with Medical categories.
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.
Histone Deacetylases
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Author : Eric Verdin
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-06
Histone Deacetylases written by Eric Verdin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-06 with Medical categories.
A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.
Histone Deacetylases
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Author : Sibaji Sarkar
language : en
Publisher:
Release Date :
Histone Deacetylases written by Sibaji Sarkar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Cytology categories.
This volume provides different methodologies for all classes of histone deacetylases, which includes detailed procedures on Class I and II histone deacetylase inhibitors, SIRT inhibitors, and bromodomain inhibitors. Histone Deacetylases: Methods and Protocols is divided into four sections: Sections A and B describe methodologies used to detect the activity, function, or chromatin location of HDACs 1 through 11, with Section A discussing Class I and Section B discussing class II histone deacetylases; Section C focuses on the methodologies for cloning and characterizing the acetylation of SIRTs 1 through 7; and Section D describes methods related to histone deacetylase inhibitors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Histone Deacetylases: Methods and Protocols, is a valuable resource for investigators working on epigenetics, molecular biology, and genetics.
Hdac Hat Function Assessment And Inhibitor Development
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Author : Oliver H. Krämer
language : en
Publisher: Springer Nature
Release Date : 2022-10-18
Hdac Hat Function Assessment And Inhibitor Development written by Oliver H. Krämer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-18 with Science categories.
This fully updated edition provides a series of methods for how best to assess functions of histone deacetylases and acetyltransferases. The disease-relevance of dysregulated protein deacetylation by overexpressed or aberrantly activated histone deacetylases has spurred an intense search for novel and improved inhibitors of these enzymes, as reflected in this collection. Expert contributors explore the generation and evaluation of novel histone deacetylase inhibitors and new and improved techniques to assess acetylation-dependent molecular mechanisms in vitro and in vivo. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, HDAC/HAT Function Assessment and Inhibitor Development: Methods and Protocols, Second Edition serves as an ideal guide for researchers seeking to further elucidate this vital area of study.
Histone Deacetylases The Biology And Clinical Implication
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Author : Tso-Pang Yao
language : en
Publisher: Springer
Release Date : 2011-09-10
Histone Deacetylases The Biology And Clinical Implication written by Tso-Pang Yao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-10 with Medical categories.
The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.
Histone Deacetylase Inhibitors Epidrugs For Neurological Disorders
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Author : Shabir Ahmad Ganai
language : en
Publisher: Springer
Release Date : 2019-07-02
Histone Deacetylase Inhibitors Epidrugs For Neurological Disorders written by Shabir Ahmad Ganai and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-02 with Medical categories.
This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors’ therapeutic efficacy against various neurological complications.
Histone Deacetylase Inhibitors In Combinatorial Anticancer Therapy
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Author : Shabir Ahmad Ganai
language : en
Publisher: Springer Nature
Release Date : 2020-11-23
Histone Deacetylase Inhibitors In Combinatorial Anticancer Therapy written by Shabir Ahmad Ganai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-23 with Medical categories.
This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.
Histone Deacetylase Inhibitors As Cancer Therapeutics
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Histone Deacetylase Inhibitors As Cancer Therapeutics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Medical categories.
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics." Provides invaluable information on the exciting and fast-moving field of cancer research This thematic volume looks at "Histone Deacetylase Inhibitors as Cancer Therapeutics" Outstanding and original reviews
Histone Deacetylase Inhibitors Epidrugs For Neurological Disorders
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Author : Shabir Ahmad Ganai
language : en
Publisher:
Release Date : 2019
Histone Deacetylase Inhibitors Epidrugs For Neurological Disorders written by Shabir Ahmad Ganai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Biochemistry categories.
This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors' therapeutic efficacy against various neurological complications.
Histone Deacetylase Inhibitors Hdis
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Author : Beverly D. Carson
language : en
Publisher: Nova Science Publishers
Release Date : 2015-05-07
Histone Deacetylase Inhibitors Hdis written by Beverly D. Carson and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-07 with HEALTH & FITNESS categories.
Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyze the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.