Homocysteine Metabolism In Health And Disease

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Homocysteine Metabolism In Health And Disease

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Author : Govind Prasad Dubey
language : en
Publisher: Springer Nature
Release Date : 2022-05-12

Homocysteine Metabolism In Health And Disease written by Govind Prasad Dubey and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-12 with Medical categories.

This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.

Homocysteine In Health And Disease

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Author : Ralph Carmel
language : en
Publisher: Cambridge University Press
Release Date : 2001-07-19

Homocysteine In Health And Disease written by Ralph Carmel and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-19 with Medical categories.

This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.

Homocysteine In Protein Structure Function And Human Disease

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Author : Hieronim Jakubowski
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-20

Homocysteine In Protein Structure Function And Human Disease written by Hieronim Jakubowski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-20 with Science categories.

Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease. ​

Focus On Homocysteine And The Vitamins

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Author : Christina Bolander-Gouaille
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-22

Focus On Homocysteine And The Vitamins written by Christina Bolander-Gouaille and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-22 with Medical categories.

During the last 10-12 years, the research on homocysteine has become very active. About 1500 of articles are now published each year on homocysteine and the vitamins involved in its metabolism. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalised by treatment with folate and/or vitamines B12 and B6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialised journals. The author has realised the difficulties for the practitioner in keeping updated. This second edition has been thoroughly updated and also offers more data on the vitamins. Over 1600 references are made available.

Homocysteine Metabolism From Basic Science To Clinical Medicine

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Author : Ian Graham
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Homocysteine Metabolism From Basic Science To Clinical Medicine written by Ian Graham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described. To date, evidence strongly supports the hypotheses that Hyperhomocysteinemia is a strong independent determinant of vascular disease and Many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins.£/LIST£ The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. Against this background of growing recognition of the importance of homocysteine as a factor in coronary artery disease, cerebrovascular disease, stroke, and peripheral vascular disease, the editors conceived of a state-of-the-art monograph on homocysteine and its relationships to disease. The contributors would be those scientists who, in fact, had written the history of this field of study over the past third of a century. The editors invited the leading investigators in the world to contribute chapters in their own areas of expertise to this monograph and to deliver those papers at the first International Meeting on Homocysteine in Ireland, which has emerged as an important study center and where the first cases of homocystinuria were reported more than three decades ago.

Homocysteine

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Author : Kilmer S. McCully
language : en
Publisher:
Release Date : 2014

Homocysteine written by Kilmer S. McCully and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Science categories.

In the aftermath of the discovery of the essential amino acid methionine in 1922, a new sulfur amino acid was discovered a decade later by Vincent DuVigneaud as a product of the degradation of methionine. This new amino acid, homocysteine, was found to be an important intermediate compound in the metabolism of methionine, cysteine and other sulfur amino acids through studies in animals. Although methylation reactions and one carbon metabolism were found to be related to the metabolism of homocysteine, little was known of the biomedical significance of this obscure sulfur amino acid in the 1950s. The studies of children with mental retardation, dislocated optic lenses, osteoporosis and other skeletal abnormalities, and a propensity for arterial and venous thrombosis, revealed the new inherited disease homocystinuria in 1962. A new concept of the importance of homocysteine in human disease was developed after the chance observation of rapidly advancing arteriosclerosis in children with different inherited enzymatic abnormalities of homocysteine metabolism by Kilmer McCully in 1969. This concept led to the development of the Homocysteine Theory of Arteriosclerosis, which stimulated an extraordinary effort to understand the importance of homocysteine in human disease by investigators in laboratories and clinics worldwide. As a result of over 17,500 published investigations in subsequent years, the obscure sulfur amino acid homocysteine was elevated to the status of "the cholesterol of the 21st century" because of its prominent involvement in human vascular disease. Extensive human studies identified the elevation of plasma homocysteine as a potent, independent risk factor for vascular disease, including coronary heart disease, cerebrovascular disease, and peripheral vascular disease. Many other important human diseases were subsequently found to be affected by homocysteine, as described by the authors of several chapters in the present book. These diseases, many of which are correlated with aging, include neurodegenerative diseases and dementia, epilepsy, uremia, osteoporotic fractures, anemia of renal failure, infection by HIV+, glaucoma, macular degeneration, bariatric surgery for obesity, celiac disease and psoriasis.

Focus On Homocysteine

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Author : Christine Bolander-Gouaille
language : en
Publisher: Springer
Release Date : 2013-03-09

Focus On Homocysteine written by Christine Bolander-Gouaille and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.

During the last 8-10 years the research on homocysteine has become very active. Hundreds of articles are now published each year. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalized by treatment with folate and/or vitamines B 12 and B 6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialized journals. The author has realized the difficulties for the practitioner in keeping updated.

Nutritional Management And Metabolic Aspects Of Hyperhomocysteinemia

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Author : Mostafa I. Waly
language : en
Publisher: Springer Nature
Release Date : 2021-03-31

Nutritional Management And Metabolic Aspects Of Hyperhomocysteinemia written by Mostafa I. Waly and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-31 with Medical categories.

Elevated blood concentrations of homocysteine, B vitamins deficiencies and oxidative stress are etiological factors for many human chronic diseases, yet the etiologic relationship of hyperhomocysteinemia to these disorders remains poorly understood. Clinical trials continue to support the notion that hyperhomocysteinemia is involved in the pathogenesis of oxidative stress and its associated impairment of cellular redox status. Antioxidants, phytochemicals, and bioactive agents are thought to be associated with the reduction of oxidative stress and reducing risk of chronic diseases, yet their role in preventing hyperhomocysteinemia-mediated oxidative stress has not been well covered in the literature. Nutritional Management and Metabolic Aspects and of Hyperhomocysteinemia comprehensively covers the nutritional-based intervention for combating hyperhomocysteinemia-mediated oxidative stress, metabolic regulation of homocysteine-dependent transulfuration and transmethylation pathways, and the identification of novel biomarkers for early diagnosis of hyperhomocysteinemia. The main goal of this text is to address the biochemical and nutritional aspects of hyperhomocysteinemia in relation to increasing risk of chronic diseases, providing insight into the etiology of hyperhomocysteinemia and covering new research on the effective reduction and management of hyperhomocysteinemia-associated chronic diseases. For researchers seeking a singular source for the understanding of the biochemical aspects and nutrition-based combat of hyperhomocysteinemia, its risk factors, preventive measures, and possible treatments currently available, this text provides all of the important needed information in up-to-date and comprehensive form.

Glutathione And Sulfur Amino Acids In Human Health And Disease

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Author : Roberta Masella
language : en
Publisher: John Wiley & Sons
Release Date : 2009-08-06

Glutathione And Sulfur Amino Acids In Human Health And Disease written by Roberta Masella and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-06 with Technology & Engineering categories.

The complex roles of glutathione and sulfur amino acids in human health Glutathione (γ-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease, sepsis, and others. This book provides researchers with a comprehensive review of the biochemistry, absorption, metabolism, biological activities, disease prevention, and health promotion of glutathione and sulfur amino acids. The twenty-two chapters explore such topics as: Chemistry, absorption, transport, and metabolism of GSH and sulfur amino acids Antioxidant and detoxification properties of GSH and sulfur amino acids, highlighting the enzymatic systems involved in antioxidant defenses Biological activities of GSH and sulfur amino acids and their role in modulating cell processes Role of GSH and sulfur amino acid deficiency and alteration in the onset of diseases and in aging Protective effects exerted by GSH and sulfur amino acids when used as drugs, functional foods, and nutraceuticals in humans and animals Special attention is paid to the molecular mechanisms for the modulation of transcription factors and enzyme activities, as well as the nutritional and therapeutic significance of dietary sulfur amino acids as shown in human and animal models. With more than 2,000 scientific references, this book provides food scientists, nutritionists, biochemists, food technologists, chemists, molecular biologists, and public health professionals with a comprehensive and up-to-date examination of glutathione and sulfur amino acids in human health and disease.

Folic Acid

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Author : Stephen M. Lee
language : en
Publisher:
Release Date : 2017

Folic Acid written by Stephen M. Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.

This book reviews and discusses the most relevant epidemiological aspects of OFCs and its prevention. It evaluates the role of folate and other factors in preventing OFC by analysing the health and socio-demographic data collected from a population sample. Individuals that are deficient in folates are suggested to have increase vulnerability to disease, including neurological conditions. Folates are involved in the metabolism of homocysteine which is a sulfur containing non-protein amino acid. This book will also highlight the recent advances made in understanding the effect of dietary folic acid over supplementation on neurological function. Patients with low levels of folic acid and other B vitamins, metabolism disorders, and renal failure have frequently high homocysteine levels that have been especially associated with cardiovascular and bone disease. This book reviews and analyzes the most important results about the effects of folic acid supplementation on clinical targets and it focuses on the effects of folic acid therapy on clinical outcomes of chronic renal failure patients with high homocysteine levels.