Homocysteine Metabolism From Basic Science To Clinical Medicine
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Homocysteine Metabolism From Basic Science To Clinical Medicine
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Author : Ian Graham
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Homocysteine Metabolism From Basic Science To Clinical Medicine written by Ian Graham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described. To date, evidence strongly supports the hypotheses that Hyperhomocysteinemia is a strong independent determinant of vascular disease and Many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins.£/LIST£ The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. Against this background of growing recognition of the importance of homocysteine as a factor in coronary artery disease, cerebrovascular disease, stroke, and peripheral vascular disease, the editors conceived of a state-of-the-art monograph on homocysteine and its relationships to disease. The contributors would be those scientists who, in fact, had written the history of this field of study over the past third of a century. The editors invited the leading investigators in the world to contribute chapters in their own areas of expertise to this monograph and to deliver those papers at the first International Meeting on Homocysteine in Ireland, which has emerged as an important study center and where the first cases of homocystinuria were reported more than three decades ago.
Homocysteine In Protein Structure Function And Human Disease
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Author : Hieronim Jakubowski
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-20
Homocysteine In Protein Structure Function And Human Disease written by Hieronim Jakubowski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-20 with Science categories.
Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
Homocysteine Metabolism In Health And Disease
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Author : Govind Prasad Dubey
language : en
Publisher: Springer
Release Date : 2023-05-14
Homocysteine Metabolism In Health And Disease written by Govind Prasad Dubey and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-14 with Medical categories.
This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.
Homocysteine And Vascular Disease
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Author : K. Robinson
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Homocysteine And Vascular Disease written by K. Robinson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was apparent.
Homocysteine In Health And Disease
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Author : Ralph Carmel
language : en
Publisher: Cambridge University Press
Release Date : 2001-07-19
Homocysteine In Health And Disease written by Ralph Carmel and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-19 with Medical categories.
This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.
Nanophysics Nanophotonics Surface Studies And Applications
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Author : Olena Fesenko
language : en
Publisher: Springer
Release Date : 2016-08-10
Nanophysics Nanophotonics Surface Studies And Applications written by Olena Fesenko and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-10 with Science categories.
This book presents some of the latest achievements in nanotechnology and nanomaterials from leading researchers in Ukraine, Europe, and beyond. It features contributions from participants in the 3rd International Science and Practice Conference Nanotechnology and Nanomaterials (NANO2015) held in Lviv, Ukraine on August 26-30, 2015. The International Conference was organized jointly by the Institute of Physics of the National Academy of Sciences of Ukraine, University of Tartu (Estonia), Ivan Franko National University of Lviv (Ukraine), University of Turin (Italy), Pierre and Marie Curie University (France), and European Profiles A.E. (Greece). Internationally recognized experts from a wide range of universities and research institutions share their knowledge and key results on topics ranging from nanooptics, nanoplasmonics, and interface studies to energy storage and biomedical applications.
Focus On Homocysteine And The Vitamins
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Author : Christina Bolander-Gouaille
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-22
Focus On Homocysteine And The Vitamins written by Christina Bolander-Gouaille and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-22 with Medical categories.
During the last 10-12 years, the research on homocysteine has become very active. About 1500 of articles are now published each year on homocysteine and the vitamins involved in its metabolism. A disturbed homocysteine metabolism can be an underlying factor for pregnancy complications and fetal malformations, cardiovascular disease, dementia, psychiatric and neurologic disorders and possibly carcinogenesis. A disturbed homocysteine metabolism can in most cases be normalised by treatment with folate and/or vitamines B12 and B6. Many of these findings therefore directly concern most practitioners. However, if there are good reviews covering single aspects of this research, these are published in specialised journals. The author has realised the difficulties for the practitioner in keeping updated. This second edition has been thoroughly updated and also offers more data on the vitamins. Over 1600 references are made available.
Autoantibodies Research Progress
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Author : Quentin P. Dubois
language : en
Publisher: Nova Publishers
Release Date : 2008
Autoantibodies Research Progress written by Quentin P. Dubois and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
An autoantibody is an antibody (a type of protein) manufactured by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases in humans, most notably lupus erythematosus, are caused by such autoantibodies. This book presents the latest research from around the world.
Folate In Health And Disease
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Author : Lynn B. Bailey
language : en
Publisher: CRC Press
Release Date : 2009-11-24
Folate In Health And Disease written by Lynn B. Bailey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-24 with Medical categories.
During the fifteen years since the bestselling first edition of Folate in Health and Disease was published, there have been thousands of new research studies related to folate and its role in health and disease. The second edition of the book uniquely bridges the gap between basic science and public health/clinical medicine.Presents Groundbreaking
Laboratory Assessment Of Vitamin Status
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Author : Dominic J. Harrington
language : en
Publisher: Academic Press
Release Date : 2018-11-28
Laboratory Assessment Of Vitamin Status written by Dominic J. Harrington and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-28 with Medical categories.
Laboratory Assessment of Vitamin Status provides a comprehensive understanding of the limitations of commonly used approaches used for the evaluation of vitamin status, reducing harm in the general health setting. It outlines the application of ‘Best Practice’ approaches to the evaluation of vitamin status, giving physicians and other healthcare professionals the opportunity to make evidence-based interventions. Nearly every metabolic and developmental pathway in the human body has a dependency on at least one micronutrient. Currently, the clinical utility of approaches taken by laboratories for the assessment of vitamin status is generally poorly understood, missing the opportunity to diagnosis vitamin deficiencies. This essential reference gives clinical and biomedical scientists an understanding of the limitations of commonly used approaches to the evaluation of vitamin status in the general health setting through change in practice. Nutritionists and dietitians gain an understanding of more sophisticated markers of vitamin status. Describes specialist assays in sufficient detail to enable laboratories to replicate what is being performed by expert groups Provides detailed information that supports laboratories in the setting up of methods for the evaluation of vitamin status Informs laboratories looking for third party providers of specialist investigations Provides an essential overview of reference ranges for each vitamin