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Hormones In Neurodegeneration Neuroprotection And Neurogenesis


Hormones In Neurodegeneration Neuroprotection And Neurogenesis
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Hormones In Neurodegeneration Neuroprotection And Neurogenesis


Hormones In Neurodegeneration Neuroprotection And Neurogenesis
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Author : Achille G. Gravanis
language : en
Publisher: John Wiley & Sons
Release Date : 2011-06-24

Hormones In Neurodegeneration Neuroprotection And Neurogenesis written by Achille G. Gravanis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-24 with Science categories.


As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.



Sex Hormones In Neurodegenerative Processes And Diseases


Sex Hormones In Neurodegenerative Processes And Diseases
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Author : Gorazd Drevensek
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-05-02

Sex Hormones In Neurodegenerative Processes And Diseases written by Gorazd Drevensek and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-02 with Medical categories.


The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.



Neurodegenerative Processes The Role Of Sex Hormones


Neurodegenerative Processes The Role Of Sex Hormones
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Author : Luke Moore
language : en
Publisher: Murphy & Moore Publishing
Release Date : 2021-11-16

Neurodegenerative Processes The Role Of Sex Hormones written by Luke Moore and has been published by Murphy & Moore Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-16 with Medical categories.


Neurodegenerative diseases are a class of diseases in which the neurons of the brain are affected. They are generally incurable since the neurons in the brain do not reproduce in most cases. Therefore, damaged neurons cannot be replaced by the body. A few of the common neurodegenerative diseases are Parkinson's, Huntington's and Alzheimer's disease. Studies have shown that there is a connection between the progression of a few particular types of neurodegeneration and sex steroids. The effect of estrogens, through their action on cognate nuclear and membrane receptors, was shown to be neuroprotective in nature. The effect of male hormones on neuronal cells has been negative in some cases, whereas in other cases it exhibited neuroprotective behavior. This book contains some path-breaking studies in the research related to neurodegenerative processes. Also included herein is a detailed explanation of the role of sex hormones in neurodegenerative processes. Scientists and students actively engaged in this field will find this book full of crucial and unexplored concepts.



Hormones Cognition And Dementia


Hormones Cognition And Dementia
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Author : Eef Hogervorst
language : en
Publisher:
Release Date : 2014-05-14

Hormones Cognition And Dementia written by Eef Hogervorst and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-14 with Medical categories.


Basic and clinical research on sex steroids, ageing, and cognition to integrate existing findings with emerging data.



Gene Regulation Epigenetics And Hormone Signaling


Gene Regulation Epigenetics And Hormone Signaling
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Author : Subhrangsu S. Mandal
language : en
Publisher: John Wiley & Sons
Release Date : 2017-05-03

Gene Regulation Epigenetics And Hormone Signaling written by Subhrangsu S. Mandal and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-03 with Science categories.


The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.



Molecular Aspects Of Neurodegeneration Neuroprotection And Regeneration In Neurological Disorders


Molecular Aspects Of Neurodegeneration Neuroprotection And Regeneration In Neurological Disorders
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Author : Akhlaq A. Farooqui
language : en
Publisher: Academic Press
Release Date : 2020-09-07

Molecular Aspects Of Neurodegeneration Neuroprotection And Regeneration In Neurological Disorders written by Akhlaq A. Farooqui and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-07 with Medical categories.


Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders



New Insights Into Adult Neurogenesis And Neurodegeneration Challenges For Brain Repair


New Insights Into Adult Neurogenesis And Neurodegeneration Challenges For Brain Repair
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Author : Jose Angel Morales-Garcia
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-04

New Insights Into Adult Neurogenesis And Neurodegeneration Challenges For Brain Repair written by Jose Angel Morales-Garcia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-04 with Science categories.




Neurodegeneration And Alzheimer S Disease


Neurodegeneration And Alzheimer S Disease
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Author : Ralph N. Martins
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-10

Neurodegeneration And Alzheimer S Disease written by Ralph N. Martins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-10 with Technology & Engineering categories.


Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.



Sex And Gender Differences In Alzheimer S Disease


Sex And Gender Differences In Alzheimer S Disease
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Author : Maria Teresa Ferretti
language : en
Publisher: Academic Press
Release Date : 2021-07-23

Sex And Gender Differences In Alzheimer S Disease written by Maria Teresa Ferretti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-23 with Medical categories.


Sex and Gender Differences in Alzheimer’s Disease: The Women’s Brain Project offers for the first time a critical overview of the evidence documenting sex and gender differences in Alzheimer’s disease neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes, and socioeconomic impact on both patients and caregivers. This knowledge is crucial for clinical development, digital health solutions, as well as social and psychological support to Alzheimer’s disease families, in the frame of a precision medicine approach to Alzheimer’s disease.This book brings together up-to-date findings from a variety of experts, covering basic neuroscience, epidemiology, diagnosis, treatment, clinical trials development, socioeconomic factors, and psychosocial support. Alzheimer’s disease, the most common form of dementia, remains an unmet medical need for the planet. Wide interpersonal variability in disease onset, presentation, and biomarker profile make Alzheimer’s a clinical challenge to neuroscientists, clinicians, and drug developers alike, resulting in huge management costs for health systems and society. Not only do women represent the majority of Alzheimer’s disease patients, but they also represent two-thirds of caregivers. Understanding sex and gender differences in Alzheimer’s disease will lead to novel insights into disease mechanisms, and will be crucial for personalized disease management strategies and solutions, involving both the patient and their family. Endorsements/Reviews: "There is a clear sex and gender gap in outcomes for brain health disorders like Alzheimer’s disease, with strikingly negative outcomes for women. This understanding calls for a more systematic way of approaching this issue of inequality. This book effectively highlights and frames inequalities in all areas across the translational spectrum from bench-to-bedside and from boardroom-to-policy and economics. Closing the Brain Health Gap will help economies create recovery and prepare our systems for future global shocks." Harris A. Eyre MBBS, PhD, co-lead, Neuroscience-inspired Policy Initiative, OECD and PRODEO Institute. Instructor in Brain Health Diplomacy, Global Brain Health Institute, UCSF and TCD. "Sex and Gender Differences in Alzheimer's disease is the most important title to emerge on Alzheimer's disease in recent years.This comprehensive, multidisciplinary book is a must read for anyone with a serious interest in dementia prevention, diagnosis, treatment, care, cure and research. Precision medicine is the future of healthcare and this book represents an incredible and necessary resource to guide practice, policy and research in light of the fact that Alzheimer's disease disproportionately affects women. The combination of contributions from the most eminent experts and the most up-to-date research makes this an invaluable resource for clinicians, care providers, academics, researchers and policy makers. Given the complex nature of dementia and the multiple factors that influence risk and disease trajectory the scope of the book is both impressive and important covering sex differences in neurobiological processes, sex and gender differences in clinical aspects and gender differences linked to socioeconomic factors relevant to Alzheimer's disease. If you work in Alzheimer's disease, or indeed other dementias, then Sex and Gender Differences in Alzheimer's disease is a must have for your bookshelf." -- Sabina Brennan, PhD., C.Psychol.,PsSI., National representative for Ireland on Alzheimer Disease International's Medical and Scientific Advisory Panel



Lipids And Cellular Membranes In Amyloid Diseases


Lipids And Cellular Membranes In Amyloid Diseases
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Author : Raz Jelinek
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-27

Lipids And Cellular Membranes In Amyloid Diseases written by Raz Jelinek and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-27 with Science categories.


Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation. Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders. From the contents: * Interactions of Alpha-Synuclein with Lipids * Interaction of hIAPP and its Precursors with Membranes * Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine * The Role of Lipid Rafts in Alzheimer's Disease * Alzheimer's Disease as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases * Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease * Membrane Changes in BSE and Scrapie * Experimental Approaches and Technical Challenges for Studying Amyloid-Membrane Interactions and more