Human Dna Polymerases Biology Medicine And Biotechnology
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Human Dna Polymerases Biology Medicine And Biotechnology
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Author : Maga Giovanni
language : en
Publisher: World Scientific
Release Date : 2017-11-10
Human Dna Polymerases Biology Medicine And Biotechnology written by Maga Giovanni and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-10 with Science categories.
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes. Contents: PrefaceAbout the AuthorsHistory of DNA PolymerasesDNA Polymerases: General AspectsHuman DNA Polymerases: From Structure to FunctionHuman DNA Polymerases in Different DNA TransactionsDNA Polymerases and Human DiseasesHuman DNA Polymerases and ChemotherapyPolymerases Chain Reaction and Heat-Stable DNA Polymerases: The History and the Potential of Evolved DNA PolymerasesSynthetic Evolution of DNA Polymerases for Novel PropertiesMarket for Evolved DNA Polymerases in Routine and Medical Applications Readership: Academic and industry research scientists, from PhD students to senior professors, as well as R&D specialists and marketing experts working in biotech and pharmaceutical companies. Keywords: DNA Polymerase;DNA Replication;DNA Repair;DNA Recombination, PCR;Cancer;Neurological Diseases;Medicine;Biology;Chemotherapy;Structural Biology;Enzymology;BiotechnologyReview: Key Features: The only book to merge basic science, biotechnological applications and marketing opportunities of DNA polymerasesThe most extensive literature coverage of the field, with more than 1,000 cited references and updated with the most recent contributions received by scientists all over the worldWritten by four leading experts in DNA polymerases, it gives the most complete overview of the field from its historical origins to the latest developments
Dna Polymerases In Biotechnology
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Author : Zvi Kelman
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-18
Dna Polymerases In Biotechnology written by Zvi Kelman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-18 with Biotechnology categories.
DNA polymerases are core tools for molecular biology including PCR, whole genome amplification, DNA sequencing and genotyping. Research has focused on discovery of novel DNA polymerases, characterization of DNA polymerase biochemistry and development of new replication assays. These studies have accelerated DNA polymerase engineering for biotechnology. For example, DNA polymerases have been engineered for increased speed and fidelity in PCR while lowering amplification sequence bias. Inhibitor resistant DNA polymerase variants enable PCR directly from tissue (i.e. blood). Design of DNA polymerases that efficiently incorporate modified nucleotide have been critical for development of next generation DNA sequencing, synthetic biology and other labeling and detection technologies. The Frontiers in Microbiology Research Topic on DNA polymerases in Biotechnology aims to capture current research on DNA polymerases and their use in emerging technologies.
Modified Nucleic Acids In Biology And Medicine
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Author : Stefan Jurga
language : en
Publisher: Springer
Release Date : 2016-07-29
Modified Nucleic Acids In Biology And Medicine written by Stefan Jurga and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-29 with Medical categories.
This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Dna Polymerases
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Author :
language : en
Publisher: World Scientific
Release Date : 2010
Dna Polymerases written by and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with DNA polymerases categories.
Pcr Technology
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Author : Henry A. Erlich
language : en
Publisher:
Release Date : 1992
Pcr Technology written by Henry A. Erlich and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Science categories.
Polymerase chain reaction (PCR) technology is a revolutionary innovation which enables scientists to rapidly generate large amounts of genetic material from a slight trace which would otherwise be too small to analyze. With applications in both research and diagnostics, PCR is becoming a standard procedure in biotechnology and medical diagnostic laboratories. This book is an introduction and guide to the new technology, covering the basic methodologies and their applications in research and medicine, emphasizing practical aspects. Each chapter is written by pioneers in the field and most include detailed protocols and favorite PCR "recipes". Students and researchers in all areas of biotechnology and molecular biology will find this book the introduction to PCR they've been looking for.
Essentials Of Medical Genomics
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Author : Stuart M. Brown
language : en
Publisher: John Wiley & Sons
Release Date : 2003-08-01
Essentials Of Medical Genomics written by Stuart M. Brown and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-01 with Science categories.
This introductory reference provides a practical, concise summary of everything a physician needs to know about genomics and emerging technologies. Through extensive illustrative examples, this book offers a clear and concise starting point to understanding how medicine has been, and will be, transformed by genomics and bioinformatics. Beginning with a clear overview on the Human Genome Project and its revolutionary impact, the book further investigates new technologies in detail, including: high-throughput DNA sequencing, genome sequence databases, microarrays, proteomics, pharmacogenomics, genetic testing, and gene therapy.
Molecular Biotechnology
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Author : Bernard R. Glick
language : en
Publisher: John Wiley & Sons
Release Date : 2017-06-01
Molecular Biotechnology written by Bernard R. Glick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-01 with Science categories.
Since 1994, Molecular Biotechnology: Principles and Applications of Recombinant DNA has introduced students to the fast-changing world of molecular biotechnology. With each revision, the authors have extensively updated the book to keep pace with the many new techniques in gene isolation and amplification, nucleic acid synthesis and sequencing, gene editing, and their applications to biotechnology. In this edition, authors Bernard R. Glick and Cheryl L. Patten have continued that tradition, but have also overhauled the book's organization to Detail fundamental molecular biology methods and recombinant protein engineering techniques, which provides students with a solid scientific basis for the rest of the book. Present the processes of molecular biotechnology and its successes in medicine, bioremediation, raw material production, biofuels, and agriculture. Examine the intersection of molecular biotechnology and society, including regulation, patents, and controversies around genetically modified products. Filled with engaging figures that strongly support the explanations in the text, Molecular Biotechnology: Principles and Applications of Recombinant DNA presents difficult scientific concepts and technically challenging methods in clear, crisp prose. This excellent textbook is ideal for undergraduate and graduate courses in introductory biotechnology, as well as, courses dedicated to medical, agricultural, environmental, and industrial biotechnology applications.
Dna Technology
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Author : I. Edward Alcamo
language : en
Publisher: Gulf Professional Publishing
Release Date : 2001
Dna Technology written by I. Edward Alcamo and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Law categories.
Gives the educated layperson a survey of DNA by presenting a brief history of genetics, an outline of techniques, and indications of breakthroughs in cloning and other DNA advances. This book helps students, business people, lawyers, and jurists gain confidence in their ability to understand and appreciate DNA technology and human genetics.
Dictionary Of Dna And Genome Technology
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Author : Paul Singleton
language : en
Publisher: John Wiley & Sons
Release Date : 2012-10-25
Dictionary Of Dna And Genome Technology written by Paul Singleton and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-25 with Science categories.
DNA technology is evolving rapidly, with new methods and a fast-growing vocabulary. This unique dictionary offers current, detailed and accessible information on DNA technology to lecturers, researchers and students throughout the biomedical and related sciences. The third edition is a major update, with over 3000 references from mainstream journals and data from the very latest research – going well beyond the remit of most science dictionaries. It provides clear explanations of terms, techniques, and tests, including commercial systems, with detailed coverage of many important procedures and methods, and includes essay-style entries on many major topics to assist newcomers to the field. It covers topics relevant to medicine (diagnosis, genetic disorders, gene therapy); veterinary science; biotechnology; biochemistry; pharmaceutical science/drug development; molecular biology; microbiology; epidemiology; genomics; environmental science; plant science/agriculture; taxonomy; and forensic science.
Recombinant Dna And Biotechnology
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Author : Helen Kreuzer
language : en
Publisher:
Release Date : 1996
Recombinant Dna And Biotechnology written by Helen Kreuzer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Since the last edition was published, more European legislation has been incorporated into the law of the United Kingdom, and the third edition contains a full account of the 1992 regulations implementing European directives. The Treaty of Amst"