Human Monocytes In The Cytokine Network
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Human Monocytes In The Cytokine Network
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Author : Anje Anna te Velde
language : en
Publisher:
Release Date : 1990
Human Monocytes In The Cytokine Network written by Anje Anna te Velde and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
European Cytokine Network
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Author :
language : en
Publisher:
Release Date : 1993
European Cytokine Network written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Cytokines categories.
Human Monocytes
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Author : Marek Zembala
language : en
Publisher:
Release Date : 1989
Human Monocytes written by Marek Zembala and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.
Monocytes represent one of the major types of white blood cells in man which prevent infection by ingesting and killing invading pathogens and by releasing factors which stimulate and regulate lymphocytes. Monocytes "purify" the blood, removing immune complexes, mediating inflammatory responses, and initiating tissue repair. Human Monocytes represents an up-to-date, definitive account of this important cell. It covers the cells biochemical, immunological, and inflammatory functionsand its role in many diseases, including asthma, atherosclerosis, rheumatoid arthritis, and AIDS.
Monocyte Heterogeneity And Function
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Author : Pierre Guermonprez
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-11
Monocyte Heterogeneity And Function written by Pierre Guermonprez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-11 with Medical categories.
The Cytokine Network
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Author : Frances R. Balkwill
language : en
Publisher: Frontiers in Molecular Biology
Release Date : 2000
The Cytokine Network written by Frances R. Balkwill and has been published by Frontiers in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Cytokines categories.
Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy.They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokinereceptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to 'knock-out' production of individual cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can bepartially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli. Cytokine and cytokine antagonists have shown therapeuticpotential in a number of chronic and acute diseases. The Cytokine Network: Frontiers in Molecular Biology is not a survey of individual cytokines, but guides the reader through the latest research on the cytokine network as a whole covering genomics, signalling pathways, control of the immuneresponse, and therapeutics.
Cellular And Cytokine Networks In Tissue Immunity
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Author : International Union of Reticuloendothelial Societies. International Congress
language : en
Publisher:
Release Date : 1991
Cellular And Cytokine Networks In Tissue Immunity written by International Union of Reticuloendothelial Societies. International Congress and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
This compilation examines the defensive role of cellular and cytokine networks responding to injury, infection or inflammation of different tissue, such as the brain, epithelium, intestinal tract and respiratory tract. It covers the complex actions of diverse cytokines, including human interleukin-9, interleukin-11,
Regulatory Role Of Monocytes And Macrophages In Infection And Immunity
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Author : Adam Peres
language : en
Publisher:
Release Date : 2018
Regulatory Role Of Monocytes And Macrophages In Infection And Immunity written by Adam Peres and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
"The immune system uses a network of defense mechanisms that protects the host from infections. Although essential for host survival, this system can also be detrimental due to excessive inflammation and tissue damage. Therefore, hosts have evolved anti-inflammatory mechanisms aimed at controlling pro-inflammatory responses and contributing to host-commensal or -pathogen interactions and disease tolerance. Monocytes and macrophages are cells that are often the initiators and targets of both pro- and anti-inflammatory responses, and play major roles in the pathogenesis and regulation of many diseases. This thesis explored the role of two such immune-regulatory molecules, interleukin 10 (IL-10) and the aryl hydrocarbon receptor (AHR) in the regulation of monocyte responses.The first manuscript investigated the capacity of nasal Staphylococcus aureus isolates to induce the production of the anti-inflammatory cytokine IL-10 by human primary monocytes. Using laboratory strains of S. aureus, our lab had previously reported the importance of IL-10 in regulating T cell activation by staphylococcal superantigens (SAg). Here, we demonstrated that the induction of IL-10 by 16 nasal isolates of S. aureus differed by up to 3-fold. Mechanistically, the magnitude of IL-10 induction was due to differential degree of activation of the PI3K-Akt-mTOR pathway by S. aureus. The IL-10 response to S. aureus could also be uncoupled from the pro-inflammatory TNF-[alpha] response by both the signaling pathways used and the requirement for internalization and phagosome maturation. Lastly, the IL-10-inducing capacity of a nasal S. aureus isolate correlated with the suppression of SAg-induced T cell activation and lower Th1 cytokine production.The other manuscripts included in this thesis focused on the regulation of AHR in the context of monocyte and macrophage responses. We first examined the expression of the AHR gene program in monocytes during inflammation. To do this, we concomitantly stimulated human monocytes with either the toll-like receptor 4 (TLR4) ligand LPS or S. aureus, and an AHR ligand FICZ and found that LPS or S. aureus specifically blocked the induction of Cyp1a1 and Cyp1b1 mRNA. These enzymes metabolize AHR ligands to negatively regulate its activation. Interestingly, FICZ-induced CYP1 protein activity was restricted to monocyte-derived macrophages differentiated by GM-CSF (GM-MDMs) and was also regulated by LPS. Lastly, AHR ligands regulated cytokine production in GM-MDMs.Next, we explored the CYP1-AHR axis in the host response to endotoxin and endotoxin tolerance. Mice lacking AHR were more susceptible to endotoxemia than wild-type mice due to excessive cytokine production, but did not present an impairment in the establishment of endotoxin tolerance. We corroborated these findings in vitro using primary human monocytes. We also observed that, during endotoxemia, liver Cyp1a2 expression and activity was significantly reduced. We therefore hypothesized that Cyp1a2-deficient mice would be protected from LPS-driven immunopathology because of an increased bioavailability of AHR ligands that would dampen the inflammatory response by macrophages. However, we observed higher susceptibility of these mice to a primary LPS challenge. The mechanistic explanation for this finding is unclear and is still currently being investigated.Collectively, the work in this thesis furthered our understanding of the involvement of IL-10 and the AHR gene program in the immune regulatory role that monocytes and monocyte-derived macrophages play during commensalism and infectious diseases." --
The Cytokine Network And Immune Functions
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Author : Jacques Thèze
language : en
Publisher: Oxford University Press, USA
Release Date : 1999
The Cytokine Network And Immune Functions written by Jacques Thèze and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Cytokines are well characterized molecules that control the communication between cells. Their importance in immunology is very critical for the control of the quantity and of the quality of each specific response against foreign antigens (virus, bacteria, ...). When the cytokine network is mis-regulated disease can appear (autoimmunity, immunodeficiencies like in AIDS or cancer). This comprehensive treatment of this exciting area of molecular medicine presents an informative description of the major cytokines together with coverage of their role in the different parts of the immune system and of their implication in immunopathology, and will be of great interest to medical researchers and academics in the field. Industrial researchers with an interest in immunology will also find this book useful.
Human Monocytes
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Author : Robertus Cornelis Adrianus van Schie
language : en
Publisher:
Release Date : 1992
Human Monocytes written by Robertus Cornelis Adrianus van Schie and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
European Cytokine Network
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Author :
language : en
Publisher:
Release Date : 2006
European Cytokine Network written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.