Identification Of Biomarkers For Cancer Immunotherapy From Bench To Bedside Volume I

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Identification Of Biomarkers For Cancer Immunotherapy From Bench To Bedside Volume I

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Author : Chang Gu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-20

Identification Of Biomarkers For Cancer Immunotherapy From Bench To Bedside Volume I written by Chang Gu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-20 with Science categories.

During the past few decades, immunotherapy has become an established pillar of cancer treatment improving the survival of numerous patients with diverse solid and hematologic tumors. The leading causes behind the success are the discovery of immune checkpoint inhibitors (ICIs) and the development of chimeric antigen receptor (CAR) T/M/NK cells. As for ICIs, malignancies take advantage of the inhibitory programmed cell death protein 1/programmed cell death protein ligand 1 (PD-1/PD-L1) or cytotoxic T-lymphocyte-associated protein (CTLA-4) pathways to evade the immune system, and disruption of the axis by immune checkpoint inhibitors can achieve durable disease remissions, which has been proved by basic researches and (pre-) clinical studies among lung cancer, melanoma, renal cell cancer, head, and neck squamous cell carcinoma, urothelial cancer, and Hodgkin’s disease. However, the 5-year survival rate of patients treated with ICIs varies with each individual and also relies on tumor specific pathological or molecular subtypes. Besides, the efficacy of ICIs is still limited in terms of drug resistance and fewer potential responders. Thus, there is a big challenge to identify and develop more novel reliable ICIs, as well as sensibilize existing ICIs for patients with drug resistance or even for non-responders.

A Textbook Of From Bench To Bedside Translational Approaches In Modern Pharmaceutics

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Author : Dr. Dipti Gohil
language : en
Publisher: Chyren Publication
Release Date : 2025-07-10

A Textbook Of From Bench To Bedside Translational Approaches In Modern Pharmaceutics written by Dr. Dipti Gohil and has been published by Chyren Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-10 with Antiques & Collectibles categories.

Manual Of Molecular And Clinical Laboratory Immunology

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Author : John L. Schmitz
language : en
Publisher: John Wiley & Sons
Release Date : 2024-12-24

Manual Of Molecular And Clinical Laboratory Immunology written by John L. Schmitz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-24 with Medical categories.

THE authoritative guide for clinical laboratory immunology For nearly 50 years, the Manual of Molecular and Clinical Laboratory Immunology has been the premier resource for laboratories, students, and professionals involved in the clinical and technical details of diagnostic immunology testing. The 9th Edition continues its tradition of providing comprehensive clinical and technical information on the latest technologies used in medical and diagnostic immunology. Led by a world-renowned group of authors and editors, this new edition reflects substantial changes aimed at improving and updating the Manual’s utility while reflecting the significant transformations that have occurred since the last edition, including the revolution of gene editing and the widespread adoption of molecularly engineered cellular therapies. Topical highlights include: Laboratory Management: three new chapters cover essential aspects of quality assurance, quality improvement, and quality management, aligning with the increasingly stringent and demanding regulatory environment. Inborn Errors of Immunity: the primary immunodeficiency section has been completely updated to align with the latest International Union of Immunological Societies’ classifications of inborn errors of immunity. Functional Cellular Assays: expanded content includes detailed discussions on various functional assays critical for modern immunologic testing. Autoimmune Diseases: expanded chapters on systemic and organ-specific autoimmune disorders, including new chapters on Sjögren’s syndrome and deficiency of ADA2, as well as significant updates on organ-specific autoimmune diseases. Transplantation Immunology: updated chapters detail the assessment of immune reconstitution and ABO testing, reflecting latest practices. The 9th Edition of the Manual of Molecular and Clinical Laboratory Immunology serves as an invaluable resource for laboratory directors, clinicians, laboratory managers, technologists, and students. It provides critical insights into the selection, application, and interpretation of immunologic tests, offering practical guidance on troubleshooting, clinical application, and an understanding of test limitations. This comprehensive and up-to-date manual remains an essential tool for anyone involved in the diagnosis, evaluation, and management of immune-mediated and immune system-related disorders.

Omics Data Integration Towards Mining Of Phenotype Specific Biomarkers In Cancer Volume Ii

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Author : Liang Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-29

Omics Data Integration Towards Mining Of Phenotype Specific Biomarkers In Cancer Volume Ii written by Liang Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-29 with Science categories.

Recent Advances In Cancer Research And Therapy

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Author : Xin-Yuan Liu
language : en
Publisher: Elsevier
Release Date : 2012-05-18

Recent Advances In Cancer Research And Therapy written by Xin-Yuan Liu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-18 with Medical categories.

Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy. There is also a discussion of current cancer research in China including traditional Chinese medicine. Written by leading scientists in the field, this book provides an essential insight into the current state of cancer therapy and treatment. - Includes a wide range of research areas including a focus on biotherapy and the development of novel cancer therapeutic strategies. - Formatted for a broad audience including all working in researching cancer treatments and therapies. - Discusses special traits and results of Chinese cancer research.

Immunogenic Cell Death In Cancer From Benchside Research To Bedside Reality

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Author : Abhishek D Garg
language : en
Publisher: Frontiers Media SA
Release Date : 2016-04-29

Immunogenic Cell Death In Cancer From Benchside Research To Bedside Reality written by Abhishek D Garg and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-29 with Immunologic diseases. Allergy categories.

Classically, anti-cancer therapies have always been applied with the primary aim of tumor debulking achieved through widespread induction of cancer cell death. While the role of host immune system is frequently considered as host protective in various (antigen-bearing) pathologies or infections yet in case of cancer overtime it was proposed that the host immune system either plays no role in therapeutic efficacy or plays a limited role that is therapeutically unemployable. The concept that the immune system is dispensable for the efficacy of anticancer therapies lingered on for a substantial amount of time; not only because evidence supporting the claim that anti-cancer immunity played a role were mainly contradictory, but also largely because it was considered acceptable (and sometimes still is) to test anticancer therapies in immunodeficient mice (i.e. SCID/athymic mice lacking adaptive immune system). This latter practice played a detrimental role in appreciating the role of anticancer immunity in cancer therapy. This scenario is epitomized by the fact that for a long time the very existence of cancer-associated antigens or cancer-associated ‘danger signaling’ remained controversial. However, over last several years this dogmatic view has been considerably modified. The existence of cancer-associated antigens and ‘danger signaling’ has been proven to be incontrovertible. These developments have together paved way for the establishment of the attractive concept of “immunogenic cell death” (ICD). It has been established that a restricted class of chemotherapeutics/targeted therapeutics, radiotherapy, photodynamic therapy and certain oncolytic viruses can induce a form of cancer cell death called ICD which is accompanied by spatiotemporally defined emission of danger signals. These danger signals along with other factors help cancer cells undergoing ICD to activate host innate immune cells, which in turn activate T cell-based immunity that helps eradicate live (or residual) surviving cancer cells. The emergence of ICD has been marred by some controversy. ICD has been criticized to be either experimental model or setting-specific or mostly a concept based on rodent studies that may have very limited implications for clinical application. However, in recent times it has emerged (through mainly retrospective or prognostic studies) that ICD can work in various human clinical settings hinting towards clinical applicability of ICD. However a widespread consensus on this issue is still transitional. In the current Research Topic we aimed to organize and intensify a discussion that strives to bring together the academic and clinical research community in order to provide a background to the current state-of-the-art in ICD associated bench-side research and to initiate fruitful discussions on present and future prospects of ICD translating towards the clinical, bedside reality.

Regulation Of Cancer Immune Checkpoints

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Author : Jie Xu
language : en
Publisher: Springer Nature
Release Date : 2020-03-17

Regulation Of Cancer Immune Checkpoints written by Jie Xu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-17 with Medical categories.

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

Biotechnology And Cancer Therapeutics

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Author : Manisha Nigam
language : en
Publisher: Springer Nature
Release Date : 2025-05-13

Biotechnology And Cancer Therapeutics written by Manisha Nigam and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-13 with Science categories.

This book explores new ground in the field of cutting-edge cancer treatment modalities by presenting contemporary biotechnological developments as a component of cancer targeting techniques. It addresses the application of modern technologies in cancer detection, targeting, and the development of therapeutic strategies across fifteen comprehensive chapters. The book emphasizes the advantages of molecular techniques for cancer therapies, such as molecular diagnosis, cell and gene therapy, and immunotherapy, with a dedicated chapter on personalized cancer therapy to critically analyze the progression toward precision strategies. The chapters cover topics such as molecular biomarkers, microRNAs, and the potential of nanomedicine in cancer treatment. The authors provide expert analysis on the latest research, offering insights into the outcomes of scientific and clinical trials. Readers will also discover discussions on drug resistance, novel molecular targets, and the integration of biotechnology in drug discovery and development. Particular attention is given to the role of epigenetics and RNA interference in cancer therapy, as well as the challenges and future prospects of personalized medicine. This book is designed specifically for oncologists, cancer biologists, researchers, academicians, and students interested in understanding the most cutting-edge biotechnological aspects of cancer therapeutics. It offers a comprehensive overview of cancer prevention, therapeutics, and treatments through the perspectives of technology, medicine, and alternative therapies. Researchers in the field of biotechnology and cancer therapy will find this book invaluable for its detailed discussions and insights into the latest advancements. It serves as a crucial tool for those working in this area, providing a valuable resource for understanding the complexities of cancer therapies and fostering progress in the field.

Applications Of Biosensors In Healthcare

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Author : Md Saquib Hasnain
language : en
Publisher: Elsevier
Release Date : 2025-01-23

Applications Of Biosensors In Healthcare written by Md Saquib Hasnain and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-23 with Science categories.

Applications of Biosensors in Healthcare: Volume 3 details and explores the various ways biosensors are used in healthcare, disease management, and therapeutic delivery.This is the third volume out of three volumes covering biosensors in healthcare. The volume discusses various types of biosensors and their use in diagnostics, health monitoring, disease detection, and therapeutic delivery. Combined with the Volume 1, Fundamentals of Biosensors in Healthcare, and Volume 2, Applications of Biosensors in Healthcare, the volumes provide a holistic reference source suitable for researchers, graduate students, postgraduates, and industry professionals involved in biosensing, biosensors, and biomedical applications. - Explores the application of biosensors for an array of medical uses - Discusses current research, potential challenges, and future considerations for the biosensors in healthcare management - Contributed by global leaders and experts in the field from academia, research, and industry

Innovation And Emerging Technologies In Radiation Oncology An Issue Of Hematology Oncology Clinics Of North America

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Author : Dukagjin Blakaj
language : en
Publisher: Elsevier Health Sciences
Release Date : 2025-04-28

Innovation And Emerging Technologies In Radiation Oncology An Issue Of Hematology Oncology Clinics Of North America written by Dukagjin Blakaj and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-28 with Medical categories.

In this issue of Hematology/Oncology Clinics, guest editors Drs. Dukagjin Blakaj and Mauricio Gamez bring their considerable expertise to the topic of Innovation and Emerging Technologies in Radiation Oncology. Top experts cover key topics such as FLASH radiation therapy; biomarker driven treatment algorithms in radiation oncology; spatial fractionated radiation therapy (SFRT): mini beam applications in radiation oncology; microbiome and effects on oncology treatments; and many more. - Contains 16 relevant, practice-oriented topics including effects of radiation therapy in the tumor microenvironment and immune system; impact of social media on oncology care; regenerative medicine and toxicity management in radiation oncology; artificial intelligence, machine learning, and big data in radiation oncology; and more - Provides in-depth clinical reviews on innovation and emerging technologies in radiation oncology, offering actionable insights for clinical practice - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews