Immune Response To Cerebral Ischemia Exploring Mechanisms And Potential Treatment Targets
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Immune Response To Cerebral Ischemia Exploring Mechanisms And Potential Treatment Targets
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Author : Xiaoxing Xiong
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-10
Immune Response To Cerebral Ischemia Exploring Mechanisms And Potential Treatment Targets written by Xiaoxing Xiong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-10 with Medical categories.
Inflammation And Stroke
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Author : Giora Z. Feuerstein
language : en
Publisher: Springer Science & Business Media
Release Date : 2001
Inflammation And Stroke written by Giora Z. Feuerstein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
New opportunities for stroke prevention and therapeutics: a hope from anti-inflammatory drugs?.- Inflammation in stroke and CNS trauma - experimental and clinical evidence.- Clinical evidence of inflammation as a risk factor in ischemic stroke.- Inflammation as a risk factor for stroke: evidence from experimental models.- Inflammatory and immune responses to CNS injury: beneficial and detrimental components.- Salutary effect of autoimmune T cells after central nervous system injury.- Traumatic brain injury: is head trauma an inflammatory disease?.- Cyclic activation and inactivation of brain vessels involving inflammatory mediators - implications for stroke.- Inflammatory cells in stroke.- Do leukocytes play a role in focal ischemia in the brain? An objective review of the literature.- The role of microglia in ischemic brain injury.- Inflammatory activation of brain cells by hypoxia: transcription factors and signaling pathways.- Inflammatory cytokines, interleukins and chemokines in stroke and CNS trauma.- Cytokine effects on CNS cells: implications for the pathogenesis and prevention of stroke.- Interleukin-10 in cerebral ischemia and stroke.- Chemokines and ischemic stroke.- Biphasic activity of tumor necrosis factor in stroke and brain trauma: interaction with reactive oxygen species.- Interleukin-1 and IL-1 receptor antagonist in stroke: mechanisms and potential therapeutics.- Inflammatory cytokines in CNS trauma.- Inflammation in cerebral thrombosis, angiogenesis and matrix regulation: a new perspective in stroke research and therapeutics.- Microvessel integrin expression during focal cerebral ischemia.- The inflammatory response in focal cerebral ischemia.- Chronic neuronal perturbation mediated by RAGE, a receptor for ?-sheet fibrils and S100/calgranulins.- Mediators of inflammation and blood-brain barrier permeability in cerebral ischemia.- Inflammatory proteases and oxygen radicals in stroke.- The role of metalloproteinases on blood-brain barrier breakdown after ischemic stroke.- Matrix metalloproteinases and their inhibitors in hypoxia/reoxygenation and stroke.- Extracellular matrix-degrading metalloproteinases and neuroinflammation in stroke.- Anti-oxidant strategies to treat stroke.- Inflammatory adhesion molecules, kinins, nitric oxide complement factors and lipid mediators in stroke.- Selectin-and complement-mediated mechanisms of tissue injury in stroke.- The kallikrein-kinin system in ischemic and traumatic brain injury.- Nitric oxide, nitric oxide synthases and cyclooxygenase-2 in experimental focal stroke.
Brain Edema
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Author : Jerome Badaut
language : en
Publisher: Academic Press
Release Date : 2017-07-19
Brain Edema written by Jerome Badaut and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-19 with Medical categories.
Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment. Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma. In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective. Presents a comprehensive understanding of the molecular mechanisms involved in edema formation and resolution Discusses the specific role of edema development in several pathologies, including traumatic brain injury, stroke, brain tumors, cardiac arrest, and liver failure Proposes a new classification of edema based on molecular processes Discusses clinical management of new clinical trials coming from pre-clinical studies Addresses the possible link between edema formation, other molecular and cellular processes, including inflammation and neuroinflammation
Advances In Neuroprotective Agents For Cerebral Ischemia Treatment
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Author : Yongjun Sun
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-20
Advances In Neuroprotective Agents For Cerebral Ischemia Treatment written by Yongjun Sun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-20 with Science categories.
Crosstalk Between Peripheral And Local Immune Response In The Pathophysiology Of Stroke And Neurodegeneration Diseases
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Author : Yuanjian Fang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-27
Crosstalk Between Peripheral And Local Immune Response In The Pathophysiology Of Stroke And Neurodegeneration Diseases written by Yuanjian Fang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-27 with Medical categories.
10 Years Of Frontiers In Genetics Past Discoveries Current Challenges And Future Perspectives
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Author : William C. Cho
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-02
10 Years Of Frontiers In Genetics Past Discoveries Current Challenges And Future Perspectives written by William C. Cho and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-02 with Science categories.
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases
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Author : Min Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-23
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases written by Min Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-23 with Science categories.
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedentedly helped capture much more useful information for the diagnosis, treatment, prognosis, and drug discovery of ARNDs. The first step towards a multi-omics analysis is to establish reliable and robust multi-omics datasets. In the past years, a few important ARNDs-associated multi-omics databases like Allen Brain have been constructed, which raised immediate needs like data curation, normalization, interpretation, and visualization for integrative multi-omics explorations. Though there have been several well-established multi-omics databases for ARNDs like Alzheimer’s disease, similar databases for other ARNDs are still in urgent need. After the databases establish, many computational tools and experiential strategies should be developed specifically for them. First, the multi-omics data are usually extremely noisy, complex, heterogeneous and in high dimension, which presents the need for appropriate denoising and dimension reduction methods. Second, since the multi-omics and non-omics data like pathological and clinical data are usually in different data spaces, a useful algorithm to mapping them into the same data space and integrate them is nontrivial. In the multi-omics era, there are numerous data-centric tools for the integration of multi-omics datasets, which could be generally divided into three categories: unsupervised, supervised, and semi-supervised methods. Commonly used algorithms include but not limited to Bayesian-based methods, Network-based methods, multi-step analysis methods, and multiple kernel learning methods. Third, methods are needed in studying and verifying the association between two or more levels of multi-omics data and non-omics data. For example, expression quantitative trait loci (eQTL) analysis is widely used to infer the association between a single nucleotide polymorphism (SNP) and the expression of a gene. Recently, the association between omics data and more complex data like pathological and clinical imaging data has been a hot research topic. The outcomes may reveal the underlying molecular mechanism and promote de novo drug design as well as drug repurposing for ARNDs. Here, we welcome investigators to share their Original Research, Review, Mini Review, Hypothesis and Theory, Perspective, Conceptual Analysis, Data Report, Brief Research Report, Code related to multi-omics studies of ARNDs, which can be applied for better diagnosis, treatment, prognosis and drug discovery of human diseases in the future era of precision medicine. Potential contents include but are not limited to the following: ▪ Methods for integrating, interpreting, or visualizing two or more omics data. ▪ Methods for identifying interactions between different data modalities. ▪ Methods for disease subtyping, biomarker prediction. ▪ Machine learning or deep learning methods on dimensional reduction and feature selection for big noisy data. ▪ Methods for studying the association among different omics data or between omics and non-omics data like clinical, pathological, and imaging data. ▪ Review of multi-omics resource about ARNDs and/or CNS aging. ▪ Experimental validation of biomarkers identified from multi-omics data analysis. ▪ Disease diagnosis and prognosis prediction from imaging and non-imaging data analysis, or both. ▪ Clinical applications or validations of findings from multi-omics data analysis.
Advances In Brain Disorders From Mechanisms To Therapeutic Targets
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Author : Arianna Bellucci
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-20
Advances In Brain Disorders From Mechanisms To Therapeutic Targets written by Arianna Bellucci and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-20 with Science categories.
Rational Basis For Clinical Translation In Stroke Therapy
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Author : Giuseppe Micieli
language : en
Publisher: CRC Press
Release Date : 2014-08-27
Rational Basis For Clinical Translation In Stroke Therapy written by Giuseppe Micieli and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-27 with Medical categories.
Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs that showed neuroprotection in the experimental setting failed to translate into the clinic because of their toxicity or lack of efficacy. Researchers in the field now face the crucial need to develop effective stroke therapies and successfully translate novel strategies into the clinical setting. Rational Basis for Clinical Translation in Stroke Therapy presents the most recent promising preclinical approaches and the most updated clinical evidence for treating stroke patients. By bringing together the experience of accomplished stroke researchers and clinicians, the book is a useful tool for improving the treatment and management of stroke patients. The book describes current approaches for the management of stroke patients including thrombolysis and mechanical recanalization procedures as well as other clinically relevant topics such as diagnosis, imaging, risk factors, and prevention. Also described are emerging interventions based on the use of stem cells, botulinum toxin, and antidepressants which complement emergency stroke treatment and conventional rehabilitation procedures. Clinical approaches are integrated with the most promising therapeutic opportunities based on targeting the immune system, hypothermia, and postconditioning. The book also covers issues related to the improvement of R&D strategies in stroke therapeutics, aimed at the implementation of preclinical approaches with stroke model guidelines and at the optimization of clinical trial design. This volume is a reference for all those interested in the rational development of novel stroke therapeutics.
Myocardial Protection
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Author : Tomas A. Salerno
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Myocardial Protection written by Tomas A. Salerno and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.
Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.
