Crosstalk Between Peripheral And Local Immune Response In The Pathophysiology Of Stroke And Neurodegeneration Diseases
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Crosstalk Between Peripheral And Local Immune Response In The Pathophysiology Of Stroke And Neurodegeneration Diseases
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Author : Yuanjian Fang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-27
Crosstalk Between Peripheral And Local Immune Response In The Pathophysiology Of Stroke And Neurodegeneration Diseases written by Yuanjian Fang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-27 with Medical categories.
Crosstalk Between Peripheral And Local Immune Response In The Pathophysiology Of Stroke And Neurodegeneration Diseases Volume Ii
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Author : Yuanjian Fang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-06
Crosstalk Between Peripheral And Local Immune Response In The Pathophysiology Of Stroke And Neurodegeneration Diseases Volume Ii written by Yuanjian Fang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-06 with Medical categories.
Accumulating evidence reveals both local and peripheral immune systems participated in the pathophysiology changes of acute and chronic neurological diseases. Immune cell activation facilitates inflammatory response in neurological diseases such as stroke, Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. The immune response initiated by brain local cells (microglia and astrocytes) and peripheral blood cells (monocytes/macrophages, neutrophil, T cells, B cells), are now commonly thought to contribute “double-edged sword” effects to the progression of neurological diseases, which not only promoting repair and recovery, but also accelerating brain injury. Meanwhile, local and peripheral immune responses have complex crosstalk in the development of post-stroke injury and neurodegeneration disease.
Peripheral Immune System And Neurodegenerative Disease
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Author : Ke Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-15
Peripheral Immune System And Neurodegenerative Disease written by Ke Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-15 with Science categories.
Aging Peripheral Inflammation And Neurodegeneration
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Author : Caroline Haikal
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-26
Aging Peripheral Inflammation And Neurodegeneration written by Caroline Haikal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Science categories.
Aging is a major risk factor for several neurodegenerative diseases, including Parkinson’s and Alzheimer’s disease. The immune response is often dysregulated in aging, leading to a predisposition towards a state of chronic inflammation. The precise processes which support this inflammatory state are still a subject of debate, however, cell- and tissue-specific transcriptional changes in several immune-related genes have been identified as potential drivers. In addition to genetic changes, losses in the bacterial diversity within the microbiome are also observed during aging. However, it is unclear whether this may be a cause or consequence of inflammation. Host-microbiome interactions are highly complex and are known to modulate the immune response in several ways. For instance, while bacteria and some bacterial byproducts such as short chain fatty acids can induce differentiation of regulatory T cells and stimulate secretion of anti-inflammatory cytokines, other byproducts can activate pathogen recognition receptors to induce inflammation. Bacteria can also regulate the transcription of human genes that regulate immune homeostasis and pathogen response. In turn, microRNAs produced by the gut epithelium can regulate transcription in bacteria.
Immune Response To Cerebral Ischemia Exploring Mechanisms And Potential Treatment Targets
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Author : Xiaoxing Xiong
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-10
Immune Response To Cerebral Ischemia Exploring Mechanisms And Potential Treatment Targets written by Xiaoxing Xiong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-10 with Medical categories.
Role Of Inflammation In Neurodegenerative Diseases
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Author : Maya Koronyo-Hamaoui
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13
Role Of Inflammation In Neurodegenerative Diseases written by Maya Koronyo-Hamaoui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Medical categories.
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases
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Author : Pukar Khanal
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-02
Targeting Neuroinflammation For Novel Therapeutics In Neurodegenerative Diseases written by Pukar Khanal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-02 with Science categories.
Neurodegenerative disorders have increasing incidence with limited treatment options. Approaches to target neuroinflammation in various neurodegenerative disorders, such as Alzheimer’s disease (AD), involve a quest for innovative therapeutics. A comprehensive understanding of the quest for small compounds that improve amyloid processing, regulate autophagy, hinder Aß accumulation, and investigate the array of phytochemicals present in naturally occurring nootropics (ethnomedicines) and polypharmacology may facilitate the exploration of diverse pharmacological approaches to impede disease advancement. Galantamine from snowdrops (Galanthus spp.) is just one example of a current core medication used in the management of cognitive decline, pointing to the potential of small molecules in this context. In addition, the combinations of computational and experimental pharmacological methods enable the exploration of small molecules within crucial neurodegenerative processes, which can help to develop potential therapeutic compounds.
Role Of Glial Cells Of The Central And Peripheral Nervous System In The Pathogenesis Of Neurodegenerative Disorders
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Author : Guanghui Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-26
Role Of Glial Cells Of The Central And Peripheral Nervous System In The Pathogenesis Of Neurodegenerative Disorders written by Guanghui Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-26 with Science categories.
Age Related Neuroimmunology Of Degeneration And Repair
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Author : Deepak Kumar Kaushik
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-13
Age Related Neuroimmunology Of Degeneration And Repair written by Deepak Kumar Kaushik and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-13 with Science categories.
Biomaterials For Brain Therapy And Repair
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Author : Sara Pedron
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-06
Biomaterials For Brain Therapy And Repair written by Sara Pedron and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with categories.
Prevalence of brain related diseases is expected to increase significantly in the next decades. Therefore, there is a vital need to develop effective, personalized models of human brain that can provide information about brain development, and the unique neurobiology of brain disorders. The use of biomaterials can play a strategic role for the future understanding and treatment of complex CNS diseases. Three-dimensional brain cultures have shown promise in disease modelling, cell transplantation and modulation of tissue repair.