Immunity To Malaria And Vaccine Strategies
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Immunity To Malaria And Vaccine Strategies
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Author : Kevin N. Couper
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-10
Immunity To Malaria And Vaccine Strategies written by Kevin N. Couper and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-10 with categories.
Malaria, caused by infection with protozoan parasites belonging to the genus Plasmodium, is a highly prevalent and lethal infectious disease, responsible for 435,000 deaths in 2017. Optimism that malaria was gradually being controlled and eliminated has been tempered by recent evidence that malaria control measures are beginning to stall and that Plasmodium parasites are developing resistance to front-line anti-malarial drugs. An important milestone has been the recent development of a malaria vaccine (Mosquirix) for use in humans, the very first against a parasitic infection. Unfortunately, this vaccine has modest and short-lived efficacy, with vaccinated individuals possibly being at increased risk of severe malarial disease when protection wanes. Thus, to define new ways to combat malaria, there remains an urgent requirement to identify the immune mechanisms that promote resistance to malarial disease and to understand why these so often fail. The review and primary research articles in this Research Topic illustrate the breadth of research performed worldwide aimed to understand the biology of the Plasmodium parasite, the roles of the various cell types that act within the immune response against the parasite, and the parasitological and immunological basis of severe malarial disease. The articles in section 1 exemplify the different vaccination strategies being developed and tested by the research community in the fight against malaria. The articles in section 2 review important overarching aspects of malaria immunology and the use of models to study human malaria. The articles in section 3 describe the ways through which the Plasmodium parasite is initially recognised by the immune system during infection, how the parasite can directly impact this critical event to restrict anti-Plasmodial immunity, and resolve the roles of key innate cell populations, such as dendritic cells, in coordinating malarial immunity. The articles in sections 4-6 outline the roles T and B cell populations play during malaria, highlighting the activation, diversification and regulation of the crucial cell types during malaria, and discuss some of the reasons adaptive immunity to malaria is often considered so poor compared with other diseases. The articles in section 7 provide up to date information on the pathogenesis of cerebral malaria, bridging our understanding of the syndrome in humans with information learned from animal models. Overall, the articles in this research, many of which are published by leaders in the malaria field, emphasize the imagination and technical advances being employed by researchers against malaria. We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Molecular Immunological Considerations In Malaria Vaccine Development
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Author : Michael F. Good
language : en
Publisher: CRC Press
Release Date : 1993-10-13
Molecular Immunological Considerations In Malaria Vaccine Development written by Michael F. Good and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-10-13 with Medical categories.
Some of the world's leading research scientists in the field have contributed to this new book on malaria vaccine development. The book examines various strategies being pursued against the different stages of the parasite (the sporozoite, asexual erythrocytic stages, and sexual stages). It describes vaccines that combat the parasite directly, vaccines aimed at preventing disease, vaccines based on attenuated parasites, and vaccines based on small, carefully defined synthetic peptides. The book provides a compendium of current approaches, lists of preferred antigens, and the results of vaccine trials to date. Molecular immunology involved with both the natural immune response to parasites and with the constraints on inducing immunity are emphasized throughout the book. Views on how vaccines may be tested and then integrated into malaria control programs are also discussed. Molecular Immunological Considerations in Malaria Vaccine Development will be useful for researchers and students in immunology, parasitology, biotechnology, vaccine design, and tropical and public health.
Malaria
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Author : Maria M. Mota
language : en
Publisher: Springer
Release Date : 2017-01-12
Malaria written by Maria M. Mota and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-12 with Medical categories.
Currently, malaria kills more than 300,000 people per year, making it a top priority of world leaders and international organizations, who are working towards implementing and coordinating efforts to eradicate this disease. An effective malaria vaccine is recognized as the key element that will decide between success and failure in this fight. At present, despite intensive research efforts, such a vaccine is not yet available for use. However, there are a number of advanced candidate vaccines with high chances of success in the short term. Malaria: Immune Response to Infection and Vaccination provides a comprehensive view on the immune response to malaria and to the different vaccines under development. The book offers the following: - Contributions by top research leaders in the field, - Comparisons of the immune responses to both malaria infection and malaria vaccines, which are traditionally treated separately, - Coverage of the immune responses to the different stages of malaria, which are frequently treated as separate fields of research.
Novel Vaccination Strategies
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Author : Stefan H. E. Kaufmann
language : en
Publisher: John Wiley & Sons
Release Date : 2006-01-24
Novel Vaccination Strategies written by Stefan H. E. Kaufmann and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-24 with Science categories.
The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.
Vaccines And Vaccination Strategies
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Author : Diane J. McLaren
language : en
Publisher:
Release Date : 1989
Vaccines And Vaccination Strategies written by Diane J. McLaren and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Allergy and Immunology categories.
Vaccination Strategies Of Tropical Diseases
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Author : F.Y. Liew
language : en
Publisher: Routledge
Release Date : 2017-11-01
Vaccination Strategies Of Tropical Diseases written by F.Y. Liew and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-01 with Medical categories.
This work in the field of tropical medicine provides an in-depth review in the development of vaccines against some of the most debilitating tropical diseases. In this multi-contributed, three-part book, with clear and ample illustrations, the reader will gather useful data and guidance to further his study in the field.
Malaria
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1991-02-01
Malaria written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-01 with Medical categories.
Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Microbial Pathogenesis Infection And Immunity
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Author : Uday Kishore
language : en
Publisher: Springer
Release Date : 2013-12-04
Microbial Pathogenesis Infection And Immunity written by Uday Kishore and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-04 with Medical categories.
The book starts with dissecting mechanisms underlying viral immune evasion via exploiting the host complement system by vaccinia virus, and by modulating the type 1 interferon response by RNA viruses. Yet another chapter looks into how viroporins expressed by different families of viruses causing influenza A virus, SARS, hepatitis C and HIV interact with several cellular pathways. Understanding of these mechanisms can aid the development of novel potential anti‐viral targets. The chapter on tuberculosis discusses the emerging importance of the innate immune mechanisms against Mycobacterium tuberculosis infection and latency. This book has a strong focus on fungal pathogenesis and immunity, starting with virulence and host factors that attain great importance in candidiasis and associated escape tricks of seriously opportunistic fungi. Two chapters on Aspergillus fumigatus elaborate on the pathogenic mechanisms: first discussing A. fumigatus‐airway epithelium interaction, followed by fungal and host factors that are paramount in the development of allergic and invasive aspergillosis. In the subsequent chapter, there is a general discussion on the innate and adaptive immune responses against primary and opportunistic fungal pathogens.
Malaria Immunology
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Author : Peter Perlmann
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2002-01-01
Malaria Immunology written by Peter Perlmann and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-01 with Medical categories.
Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition, provides a broad and up-to-date overview of the rapidly expanding field of malaria immunology and its importance in the control of this disease. The first section deals with the malaria parasite and its interactions with both the vertebrate host and the mosquitoes which transmit the disease. In the second part, the mechanisms of immunity and their regulation by environmental and genetic factors are discussed. Finally, this volume contains several chapters on malaria vaccine development, describing the application of the most recent vaccine technologies as well as ongoing and planned vaccine trials. Authored by well-recognized experts, this volume not only demonstrates the rapid progress being made in the search for vaccines against malaria, but also broadens our understanding of immunity to infection in general. It is therefore highly recommended reading for all scientists and professionals in the fields of immunology, infection and vaccine development.
Malaria Vaccine Development
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Author : Stephen L. Hoffman
language : en
Publisher: Amer Society for Microbiology
Release Date : 1996-01
Malaria Vaccine Development written by Stephen L. Hoffman and has been published by Amer Society for Microbiology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01 with Medical categories.
Malaria Vaccine Development is an important reference that investigates exciting new strategies in the field. Chapters from the world's leading authorities report major breakthroughs in vaccine design and delivery and discuss the completely new generation of multicomponent vaccines. Immunologists, vaccinologists, parasitologists, and tropical medicine clinicians and researchers will find this volume to be an essential reference.