Vaccines And Vaccination Strategies
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Vaccination Strategies Against Highly Variable Pathogens
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Author : Lars Hangartner
language : en
Publisher: Springer Nature
Release Date : 2020-09-01
Vaccination Strategies Against Highly Variable Pathogens written by Lars Hangartner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-01 with Medical categories.
Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine.
Novel Vaccination Strategies
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Author : Stefan H. E. Kaufmann
language : en
Publisher: John Wiley & Sons
Release Date : 2006-01-24
Novel Vaccination Strategies written by Stefan H. E. Kaufmann and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-24 with Science categories.
The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.
Vaccination Strategies Of Tropical Diseases
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Author : F.Y. Liew
language : en
Publisher: Routledge
Release Date : 2017-11-01
Vaccination Strategies Of Tropical Diseases written by F.Y. Liew and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-01 with Medical categories.
This work in the field of tropical medicine provides an in-depth review in the development of vaccines against some of the most debilitating tropical diseases. In this multi-contributed, three-part book, with clear and ample illustrations, the reader will gather useful data and guidance to further his study in the field.
Vaccines And Vaccination Strategies
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Author : Diane J. McLaren
language : en
Publisher:
Release Date : 1989
Vaccines And Vaccination Strategies written by Diane J. McLaren and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Allergy and Immunology categories.
Therapeutic Vaccination Strategies
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Author : P. Walden
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Therapeutic Vaccination Strategies written by P. Walden and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
The induction of immune responses against tumor cells by vaccination is rapidly evolving as a therapeutic modality with new potentials for the treatment of cancer. It is based on the fact that our immune system can identify tumor cells and, once activated, is capable of developing specific immunity against the neoplastic cells. Numerous observations and intense research clearly document the major contribution of the immune system to the prevention of cancer. And there are many re ports of patients suffering from malignant melanoma or other tumors who mount a spontaneous immune response against their tumor cells that results in tumor regression. Based on the recent advances in our understanding of the compo nents of our immune system, their interactions and the regulation of immune responses, we are now able to design vaccination strategies that induce or enhance cell-mediated immunity against tumors. A ma jor advancement came with the identification and characterization of relevant tumor antigens, which are suitable target structures for anti-tu mor immune response. First clinical trials using such vaccine strategies have yielded encouraging results in patients. However, in spite of many reported cases of successful therapy of cancer by vaccination many patients still do not experience relief after such treatments. These initial clinical trials and the accompanying investigations have revealed a number of important results that indicate the direction of future re search and development in the field.
Vaccine Analysis Strategies Principles And Control
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Author : Brian K. Nunnally
language : en
Publisher: Springer
Release Date : 2014-11-27
Vaccine Analysis Strategies Principles And Control written by Brian K. Nunnally and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-27 with Medical categories.
This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities. Topics covered include the application of both classical and modern bio-analytical tools; procedures to assure safety and control of cross contamination; consistent biological transition of vaccines from the research laboratory to manufacturing scale; whole infectious attenuated organisms, such as live-attenuated and inactivated whole-cell bacterial vaccines and antiviral vaccines using attenuated or inactivated viruses; principles of viral inactivation and the application of these principles to vaccine development; recombinant DNA approaches to produce modern prophylactic vaccines; bacterial subunit, polysaccharide and glycoconjugate vaccines; combination vaccines that contain multiple antigens as well as regulatory requirements and the hurdles of licensure.
The Vaccine Book
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Author : Barry R. Bloom
language : en
Publisher: Academic Press
Release Date : 2016-06-23
The Vaccine Book written by Barry R. Bloom and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-23 with Science categories.
The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child’s risk. Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines Gives new ideas about future vaccines and concepts Introduces new vaccines and concepts Gives ideas about challenges facing public and private industrial investors in the vaccine area Discusses the problem of declining immunization rates and vaccine hesitancy
Innovation In Vaccinology
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Author : Selene Baschieri
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-20
Innovation In Vaccinology written by Selene Baschieri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-20 with Medical categories.
Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.
Foot And Mouth Disease Vaccination And Post Vaccination Monitoring
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Author : Food and Agriculture Organization of the United Nations
language : en
Publisher: Food & Agriculture Org.
Release Date : 2018-08-21
Foot And Mouth Disease Vaccination And Post Vaccination Monitoring written by Food and Agriculture Organization of the United Nations and has been published by Food & Agriculture Org. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-21 with Health & Fitness categories.
Foot-and-mouth disease (FMD) control and/or eradication efforts have been in existence for many years in different regions, supported by an official OIE system for recognition of national control programmes and of country status to manage the trade risks for FMD reintroduction. A global FMD control strategy was announced by FAO and OIE in 2012, incorporating a progressive control pathway for FMD (PCP-FMD) that elaborates principles for the application of control measures in a step-wise manner. The OIE Performance of Veterinary Services tool helps countries to monitor the structures essential for programme implementation.Vaccination is an important component of programmes that seek to reduce the impacts of FMD and to block circulation of the causative virus in order to establish and maintain disease freedom. Choosing and successfully implementing the appropriate vaccine and vaccination regimens are affected by many dynamic factors, including (1) the diversity of the viruses to be controlled; (2) the performance characteristics and instability of vaccines; (2) the range of susceptible animal species and husbandry systems; (3) the purposes of vaccination; (4) the short-lived nature of vaccine induced immunity; and (5) the design and application of vaccination programmes. Furthermore, vaccination is unlikely to succeed unless supported by other complementary control measures. Therefore, the entire process of vaccine selection and vaccination must be continuously monitored and evaluated to ensure that it fulfils its objectives and contributes to a sustainable control of FMD. This document is intended to help guide this process. Since the variable and changing circumstances of FMD control require different approaches, the guidance is not prescriptive. Instead, it reviews the options available for vaccine selection and vaccination strategies and presents methodology to check that a potential vaccine is able to provide a protective immune response and that the implemented vaccination programme has translated this into a protective level of population immunity.
Novel Strategies In The Design And Production Of Vaccines
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Author : Sara Cohen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Novel Strategies In The Design And Production Of Vaccines written by Sara Cohen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epidemic outbreaks related to political and socio-economic instabilities, increase the needs for the development of new, advanced vaccines. In this volume, devoted to the proceedings of the 39th OHOLO Conference, we present some of the recent strategies for the design and production of novel vaccines. The advent of recombinant DNA technology has stimulated the production of several subunit vaccines. In spite of the obvious advantages to this approach, the limited immuno genicity of many subunit candidates has hindered their development. Strategies to enhance the immunogenicity of subunit vaccines is therefore critical. Several approaches toward this goal, including design of novel adjuvants and delivery systems as well as design of advantageous carriers, are presented here. Among the carriers evaluated here are polypep tides (flagellin, HBV core antigen, J3-galactosidase), attenuated virions (Vaccinia, Sindbis), and nonpathogenic licensed bacteria (Salmonella).