Implantable Light Delivery Interfaces For Optical Neural Stimulation
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Implantable Light Delivery Interfaces For Optical Neural Stimulation
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Author : Tanya Vanessa F. Abaya
language : en
Publisher:
Release Date : 2013
Implantable Light Delivery Interfaces For Optical Neural Stimulation written by Tanya Vanessa F. Abaya and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Biomedical engineering categories.
Optical Neural Interfaces
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Author : Massimo De Vittorio
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-01
Optical Neural Interfaces written by Massimo De Vittorio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-01 with categories.
Optogenetic Studies Of Brain Disease
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Author : Murtaza Mogri
language : en
Publisher: Stanford University
Release Date : 2011
Optogenetic Studies Of Brain Disease written by Murtaza Mogri and has been published by Stanford University this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Optogenetic neuromodulation is giving scientists an unprecedented ability to modulate neural circuits, providing specificity with regards to location, cell type, as well as neuromodulatory effect. On the other hand, electrical stimulation and lesions, methods commonly used to study neural circuits, are lacking in specificity, often affecting both local cells and passing axons, as well as multiple cell types. Our laboratory has been at the forefront of the field of optogenetics, having developed, for use in mammalian systems, Channelrhodopsin-2 (ChR2), an algal light-activated cation channel that depolarizes neurons in response to blue light, and Natronomonas pharaonis halorhodopsin (eNpHR), a chloride pump that hyperpolarizes neurons in response to amber light. These proteins can control neuronal activity with millisecond timescale precision, and through promoters, they can be targeted to specific cell-types in heterogeneous tissue. Along with its specificity, light stimulation with optogenetic tools often allows the recording of neural activity without the artifact that obfuscates recordings with electrical stimulation. The advantages provided by optogenetics allowed us to make a breakthrough in determining the therapeutic mechanism of deep brain stimulation, a robust treatment for Parkinson's disease in which stimulating electrodes are implanted deep in the brain. Using optogenetics, we replicated the effect of deep brain stimulation by modulating cortical inputs into the region where the stimulating electrode is normally placed. Combined with other corroborating publications, a hypothesis is emerging that electrical stimulation deep in the brain actually produces its effect by modulating cortical projections to the deep brain region. Based on this concept, several clinical studies are being done to better understand the cortical role in Parkinson's disease and determine whether cortical stimulation (potentially non-invasive), could be an alternative to the invasive implants currently used. In order to perform these experiments, we studied the transmission of visible light in brain tissue to estimate the volume of activation produced by optogenetic stimulation and developed a device to measure fluorescence in awake, behaving animals, allowing the quantification of virally transfected gene expression over time, as well as the localization of expression along axon bundles. The knowledge gained from these experiments will have a significant impact on future experiments in the broader field of optogenetics.
Bridging The Gap In Neuroelectronic Interfaces
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Author : Jeffrey R. Capadona
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-09
Bridging The Gap In Neuroelectronic Interfaces written by Jeffrey R. Capadona and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-09 with categories.
Optical Neural Interfaces
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Author : Massimo De Vittorio
language : en
Publisher:
Release Date : 2019
Optical Neural Interfaces written by Massimo De Vittorio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Cardiac Optogenetics Using Light To Observe And Excite The Heart
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Author : Tobias Bruegmann
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-15
Cardiac Optogenetics Using Light To Observe And Excite The Heart written by Tobias Bruegmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-15 with Science categories.
Topic Editor Godfrey Smith is the founder, director and honorary Chief Scientific Officer of Clyde Biosciences Ltd (UK). The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Smart Sensors And Systems
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Author : Yongpan Liu
language : en
Publisher: Springer Nature
Release Date : 2020-06-10
Smart Sensors And Systems written by Yongpan Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-10 with Technology & Engineering categories.
This book describes for readers technology used for effective sensing of our physical world and intelligent processing techniques for sensed information, which are essential to the success of Internet of Things (IoTs). The authors provide a multidisciplinary view of sensor technology from materials, process, circuits, and big data domains and showcase smart sensor systems in real applications including smart home, transportation, medical, environmental, agricultural, etc. Unlike earlier books on sensors, this book will provide a “global” view on smart sensors covering abstraction levels from device, circuit, systems, and algorithms. Profiles active research on smart sensors based on CMOS microelectronics; Describes applications of sensors and sensor systems in cyber physical systems, the social information infrastructure in our modern world; Includes coverage of a variety of related information technologies supporting the application of sensors; Discusses the integration of computation, networking, actuation, databases, and various sensors, in order to embed smart sensor systems into actual social systems.
Nanotechnologies In Neuroscience And Neuroengineering
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Author : Ioan Opris
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-05
Nanotechnologies In Neuroscience And Neuroengineering written by Ioan Opris and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-05 with categories.
Optoelectronics Recent Advances
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Author : Touseef Para
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-03-13
Optoelectronics Recent Advances written by Touseef Para and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-13 with Technology & Engineering categories.
Embark on a journey through the cutting-edge world of optoelectronics with Optoelectronics - Recent Advances. This anthology explores the diverse realms of light and electronics, from fundamental insights to groundbreaking advancements. Discover the future of quantum information processing, gold nanorod assembly, and more. This collection of seven chapters brings together leading minds, offering a glimpse into the transformative potential of recent optoelectronic research. Whether you're a curious reader or a seasoned researcher, Optoelectronics - Recent Advances invites you to witness the brilliance where ideas shine bright.
Handbook Of Neurophotonics
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Author : Francesco S. Pavone
language : en
Publisher: CRC Press
Release Date : 2020-05-10
Handbook Of Neurophotonics written by Francesco S. Pavone and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-10 with Science categories.
The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 32 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.