Optical Neural Interfaces
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Optical Neural Interfaces
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Author : Massimo De Vittorio
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-01
Optical Neural Interfaces written by Massimo De Vittorio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-01 with categories.
Neural Interfacing
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Author : Thomas D. Coates
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2008
Neural Interfacing written by Thomas D. Coates and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
In the past 50 years there has been an explosion of interest in the development of technologies whose end goal is to connect the human brain and/or nervous system directly to computers. Once the subject of science fiction, the technologies necessary to accomplish this goal are rapidly becoming reality. In laboratories around the globe, research is being undertaken to restore function to the physically disabled, to replace areas of the brain damaged by disease or trauma and to augment human abilities. Building neural interfaces and neuro-prosthetics relies on a diverse array of disciplines such as neuroscience, engineering, medicine and microfabrication just to name a few. This book presents a short history of neural interfacing (N.I.) research and introduces the reader to some of the current efforts to develop neural prostheses. The book is intended as an introduction for the college freshman or others wishing to learn more about the field. A resource guide is included for students along with a list of laboratories conducting N.I. research and universities with N.I. related tracks of study. Table of Contents: Neural Interfaces Past and Present / Current Neuroprosthesis Research / Conclusion / Resources for Students
Implantable Light Delivery Interfaces For Optical Neural Stimulation
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Author : Tanya Vanessa F. Abaya
language : en
Publisher:
Release Date : 2013
Implantable Light Delivery Interfaces For Optical Neural Stimulation written by Tanya Vanessa F. Abaya and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Biomedical engineering categories.
Neural Interface Engineering
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Author : Liang Guo
language : en
Publisher: Springer Nature
Release Date : 2020-05-04
Neural Interface Engineering written by Liang Guo and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-04 with Technology & Engineering categories.
This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.
Electrophysiology Measurements For Studying Neural Interfaces
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Author : Mohammad M. Aria
language : en
Publisher: Academic Press
Release Date : 2020-05-15
Electrophysiology Measurements For Studying Neural Interfaces written by Mohammad M. Aria and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-15 with Medical categories.
Electrophysiology Measurements for Studying Neural Interfaces helps readers to choose a proper cell line and set-up for studying different bio-electronic interfaces before delving into the electrophysiology techniques available. Therefore, this book details the materials and devices needed for different types of neural stimulation such as photoelectrical and photothermal stimulations. Also, modern techniques like optical electrophysiology and calcium imaging in this book provides readers with more available approaches to monitor neural activities in addition to whole-cell patch-clamp technology. Details steps of an electrophysiology project from start to finish for graduate students employing the technique in their research Includes sample electrophysiological studies with multiple cell lines (PC12, N2a, NG108, SHSY, and embryonic stem cell lines) to facilitate research Features data analysis of electrophysiology results from various relevant experiments and cell culture tips
Minimally Invasive Electro Optical Neural Probes For Interfacing With Optogenetic Networks
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Author : spencer patrick ward
language : en
Publisher:
Release Date : 2020
Minimally Invasive Electro Optical Neural Probes For Interfacing With Optogenetic Networks written by spencer patrick ward and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
The increasing expected lifespan is causing a higher prevalence of neurological diseases. These diseases carry an emotional and economical cost that can not be neglected by society. Key to understanding and treating these diseases are the recording and stimulating technologies available to researchers and clinicians. While metal electrodes are the oldest recording technology utilized, recent developments in optics have allowed biologists to understand nervous system function on a new level. In the past decade, engineers have begun to combine both electrical and optical modalities into a single device to increase the amount of information gained from recording and stimulation. A limiting factor for all of these implantable devices is the body's immune system response, which results in dead tissue surrounding the implant in less than 6 months. Designing a multimodal device which reduces immune response is a solution sought after in the neuroscience field. While some purely electrical devices have begun to show reduced immune response by reducing device size, there has not been a multimodal device on these size scales. This dissertation combines microfabrication techniques with small optical cores to create a minimally invasive implantable device which can perform optical and electrical interrogation of the nervous system. Chapter 2 addresses the electrical and optical challenges associated with scaling these technologies to small dimensions. Strategies to overcome these issues are described along with trade-offs of different materials used in fabrication. Chapter 3 takes these fabricated devices and looks at limitation for inserting them into tissue. Due to limitations in size, device mechanical failure is modeled as a function of each fabrication layer added to the device. These characterized devices were then tested on brain and spinal cord tissue samples to determine the maximum device length before device failure. Chapter 4 takes all of the lessons learned in fabrication and characterization to create devices which are then tested \textit{in vivo}. We are able to demonstrate that a single device can concomitantly optically stimulate neurons in the cortex and electrically record action potentials. Through immunohistology we demonstrate a negligible immune response for devices after implantation of 6 days: a critical time point in the immune system response. These results show promise for scaling this technology into arrays that can interface with larger regions of the brain.
Neural Interface Frontiers And Applications
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Author : Xiaoxiang Zheng
language : en
Publisher: Springer Nature
Release Date : 2019-11-15
Neural Interface Frontiers And Applications written by Xiaoxiang Zheng and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-15 with Medical categories.
This book focuses on the frontiers of neural interface technology, including hardware, software, neural decoding and encoding, control systems, and system integration. It also discusses applications for neuroprosthetics, neural diseases and neurorobotics, and the toolkits for basic neuroscience. A neural interface establishes a direct communication channel with the central or peripheral nervous system (CNS or PNS), and enables the nervous system to interact directly with the external devices. Recent advances in neuroscience and engineering are speeding up neural interface technology, paving the way for assisting, augmenting, repairing or restoring sensorimotor and other cognitive functions impaired due to neurological disease or trauma, and so improving the quality of life of those affected. Neural interfaces are now being explored in applications as diverse as rehabilitation, accessibility, gaming, education, recreation, robotics and human enhancement. Neural interfaces also represent a powerful tool to address fundamental questions in neuroscience. Recent decades have witnessed tremendous advances in the field, with a huge impact not only in the development of neuroprosthetics, but also in our basic understanding of brain function. Neural interface technology can be seen as a bridge across the traditional engineering and basic neuroscience. This book provides researchers, graduate and upper undergraduate students from a wide range of disciplines with a cutting-edge and comprehensive summary of neural interface engineering research.
Incorporating An Optical Waveguide Into A Neural Interface
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Author :
language : en
Publisher:
Release Date : 2016
Incorporating An Optical Waveguide Into A Neural Interface written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
An optical waveguide integrated into a multielectrode array (MEA) neural interface includes a device body, at least one electrode in the device body, at least one electrically conducting lead coupled to the at least one electrode, at least one optical channel in the device body, and waveguide material in the at least one optical channel. The fabrication of a neural interface device includes the steps of providing a device body, providing at least one electrode in the device body, providing at least one electrically conducting lead coupled to the at least one electrode, providing at least one optical channel in the device body, and providing a waveguide material in the at least one optical channel.
Modeling Design And Test Of An Integrated Optical Neural Recording Device
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Author : Brendan Michael Crowley
language : en
Publisher:
Release Date : 2014
Modeling Design And Test Of An Integrated Optical Neural Recording Device written by Brendan Michael Crowley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
It has long been a goal of neuroscientists to understand how electrophysiological activity in the nervous system corresponds to, and causes, specific physiological actions. Such knowledge could be used to develop cures for disabilities related to nervous system dysfunction, and to control artificial limbs or restore motion to a paralyzed patient. This has motivated research into technologies, broadly termed brain-machine interfaces, for interfacing with the nervous system. One category of such neural interfaces is implantable neural recording devices, which monitor and record neural signals through a microelectronic device implanted in the body. Typical implantable neural recording devices use a micro-electrode array to record electrical signals simultaneously from a multitude of neurons. Unfortunately, devices employing micro-electrode arrays have several issues from both the biological and circuit design points of view. These issues include tissue damage due to implantation of a micro-electrode array, degradation of recording fidelity over time, limited spatial resolution, the requirement to maintain charge balance in tissue, and the difficulty in implementing low-frequency (large time constant) filter cutoffs with limited chip area. These issues provided the motivation to investigate alternative methods for neural recording - namely optical methods based on fluorescence detection with voltage-sensitive fluorescent proteins. Optical recording methods can alleviate many of the issues with electrical recording, as well as provide other advantages, such as recording targeted to specific neurons/neuron types and higher spatial resolution due to reduced recording site pitch. The major limitations of fully implantable optical recording devices stem from size constraints, the attenuation of light in tissue, which limits imaging depth, and the need for genetically programmed voltage-sensitive fluorescent proteins, which must be introduced to the tissue in the case of chronic recording. This research began with investigating the feasibility of replacing an electrical neural record- ing front end with an optical front end - the conclusion being that producing an initial design was worthwhile. Thus, this thesis presents a prototype optical neural recording device for detecting individual spikes in Layer I of the brain. The device is designed for the fully implantable scenario, where space for typical fluorescence imaging optical components is limited, and a high level of integration is required. The thesis describes: 1) Modeling: a general framework for modeling near-field fluorescence detection systems is presented; the model is then extended and applied to the design of the optical neural recording device for detecting individual spikes in Layer I of the brain, taking into account light attenuation in tissue; 2) Design: the design of a high-sensitivity CMOS imaging chip used in the device; 3) Packaging: the packaging of the CMOS imager with LED dies and an excitation filter; and 4) Testing: the experimental results from testing the packaged device with a fluorescent tissue phantom designed to emulate layer I of the brain. Ideas for future work on such devices are discussed.
Advanced Rehabilitative Technology
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Author : Qingsong Ai
language : en
Publisher: Academic Press
Release Date : 2018-08-17
Advanced Rehabilitative Technology written by Qingsong Ai and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-17 with Science categories.
Advanced Rehabilitative Technology: Neural Interfaces and Devices teaches readers how to acquire and process bio-signals using biosensors and acquisition devices, how to identify the human movement intention and decode the brain signal, how to design physiological and musculoskeletal models and establish the neural interfaces, and how to develop neural devices and control them efficiently using biological signals. The book takes a multidisciplinary theme between the engineering and medical field, including sections on neuromuscular/brain signal processing, human motion and intention recognition, biomechanics modelling and interfaces, and neural devices and control for rehabilitation. Each chapter goes through a detailed description of the bio-mechatronic systems used and then presents implementation and testing tactics. In addition, it details new neural interfaces and devices, some of which have never been published before in any journals or conferences. With this book, readers will quickly get up-to-speed on the most recent and future advancements in bio-mechatronics engineering for applications in rehabilitation. Presents insights into emerging technologies and developments that are currently used or on the horizon in biological systems and mechatronics for rehabilitative purposes Gives a comprehensive background of biological interfaces and details of new advances in the field Addresses the challenges of rehabilitative applications in areas of bio-signal processing, bio-modelling, neural and muscular interface, and neural devices. Provides substantial background materials and relevant case studies for each subject