In Vitro Toxicity Testing Protocols Methods In Molecular Biology
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In Vitro Toxicity Testing Protocols
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Author : Sheila O’Hare
language : en
Publisher: Humana Press
Release Date : 2013-08-23
In Vitro Toxicity Testing Protocols written by Sheila O’Hare and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-23 with Medical categories.
In vitro toxicology is one of the most rapidly expanding areas of biological research today. It is generally conceded that this is a result of pressure from the public for safer products and environmental conditions and, in these recessionary times, pressure from company accountants, who often perceive in vitro experimentation as a cheaper option than lawsuits, fines, and expensive remediation. Toxicologists themselves form one group whose vigor and influence on the evolution of in vitro toxicology is often underestimated. Many toxicologists have for some time been unhappy with the quantity (often a result of unnecessary duplication), the reliability, and the ethical circumstances of much animal experimentation. It is hoped that the present book, In Vitro Toxicity Testing Protocols, will play some part in enabling and encouraging the more widespread use of in vitro techniques. Since in vitro toxicity testing methodology is evolving at such a rapid rate, this book can of necessity provide only a "snapshot" of the major techniques in use at the present time. As with the other publications in Humana Press' Methods in Molecular Biology series, the aim has been to supply information on the fundamental requirements for the establishment of new techniques within working laboratories and to describe a variety of basic in vitro methodologies. Certain of the techniques detailed here could more accurately be described as ex vivo rather than truly in vitro. No apology is made for the inclusion of these techniques.
In Vitro Toxicity Testing Protocols
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Author : Sheila O’Hare
language : en
Publisher: Humana Press
Release Date : 1995-05-04
In Vitro Toxicity Testing Protocols written by Sheila O’Hare and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-05-04 with Medical categories.
In Vitro Toxicity Testing Protocols is a collection of proven, state-of-the-art methods that toxicologists can use in carrying out laboratory studies. The book's expert contributors offer a variety of efficient in vitro toxicology techniques that can be applied regularly in your lab, or can serve as the fundamental basis for the establishment of novel techniques in working laboratories. All the procedures are highly reliable. Also included are ex vivo techniques, whose development embraces the twin aims of reduction and refinement of the use of laboratory animals; the editors believe this is an important step toward the ethical treatment of laboratory animals. In keeping with the successful format of preceding volumes of the Methods in Molecular Biology series, concise, easy-to-follow, step-by-step protocols are provided for each technique, together with extensive notes that cover troubleshooting and offer special tips to ensure the successful completion of your experiments.
In Vitro Toxicity Testing Protocols Methods In Molecular Biology
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Author : Christopher K. Atterwill
language : en
Publisher:
Release Date : 1995
In Vitro Toxicity Testing Protocols Methods In Molecular Biology written by Christopher K. Atterwill and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
In Vitro Toxicity Testing Protocols is a collection of proven, state-of-the-art methods that toxicologists can use in carrying out laboratory studies. The book's expert contributors offer a variety of efficient in vitro toxicology techniques that can be applied regularly in your lab, or can serve as the fundamental basis for the establishment of novel techniques in working laboratories. All the procedures are highly reliable. Also included are ex vivo techniques, whose development embraces the twin aims of reduction and refinement of the use of laboratory animals; the editors believe this is an important step toward the ethical treatment of laboratory animals. In keeping with the successful format of preceding volumes of the Methods in Molecular Biology series, concise, easy-to-follow, step-by-step protocols are provided for each technique, together with extensive notes that cover troubleshooting and offer special tips to ensure the successful completion of your experiments.
Information Resources In Toxicology Volume 1 Background Resources And Tools
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-05-16
Information Resources In Toxicology Volume 1 Background Resources And Tools written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-16 with Technology & Engineering categories.
This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources - Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles - Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals - Explores recent internet trends, web-based databases, and software tools in a section on the online environment - Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents - Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field
Drug Testing In Vitro
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Author : Uwe Marx
language : en
Publisher: John Wiley & Sons
Release Date : 2007-02-27
Drug Testing In Vitro written by Uwe Marx and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-27 with Science categories.
Here, expert scientists from industry and academia share their knowledge on the assembly of functional human tissues in vitro and how to design drug screenings predictive of human exposure. In so doing, they combine the latest technological developments with strategic outlooks, such as novel cell and tissue systems for drug screening and testing, as well as emerging in vitro culture technologies. Equally importantly, the book does not shy away from regulatory acceptance and ethical issues.
Molecular And Biochemical Toxicology
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Author : Robert C. Smart
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-05
Molecular And Biochemical Toxicology written by Robert C. Smart and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-05 with Science categories.
An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition. Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include: New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.
Cytotoxicity A Crucial Toxicity Test For In Vitro Experiments
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2025-04-02
Cytotoxicity A Crucial Toxicity Test For In Vitro Experiments written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-02 with Medical categories.
Cytotoxicity experiments are performed in order to assess the possible toxic effects and safety profiles of chemical, physical and biological agents. There are several mechanisms by which a substance may lead to cellular toxicity, including impairment of cellular functions, disruption of the cellular membrane and/or cellular signalling pathways or inducing an immune response. Cytotoxicity testing involves both in vitro and in vivo methods. In vitro methods offer a rapid and cost-effective approach, while in vivo methods provide a more comprehensive assessment. Rigorous cytotoxicity testing is essential for meeting regulatory standards, enhancing user safety, and improving the product quality of drugs, cosmetics and medical devices. Ensuring the accuracy and reliability of data obtained from in vitro cytotoxicity studies is critical for evaluating the safety profiles of different agents. In the past years, many in vitro methods have been developed to evaluate the viability of cells, and each method has its advantages, disadvantages, strengths and limitations. There are different methods for determining cytotoxicity. They can be summarized as "Staining Methods", "Colorimetric Methods", "Fluorometric Methods", "Luminometric Methods" and "Other Methods". The researchers should choose the most appropriate method for their research by considering the cell type they will use, the dose and properties of the chemical, physical and biological agents, and the mechanism through which it causes cell death (such as apoptosis, necrosis, autophagy). This book mainly focuses on cytotoxicity determination as the primary and crucial step in evaluating toxicity. In this book, the readers will find traditional and new methods used to evaluate cytotoxicity. We believe that readers will get qualified scientific knowledge and a general overview of the importance of cytotoxicity testing.
Information Resources In Toxicology
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Author : P.J. Bert Hakkinen
language : en
Publisher: Elsevier
Release Date : 2000-01-10
Information Resources In Toxicology written by P.J. Bert Hakkinen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01-10 with Medical categories.
Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added.This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. - Serves as an all-in-one resource for toxicology information - New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports - Updated to include the latest internet and electronic sources, e-mail addresses, etc. - Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects
Animal Cell Culture Techniques
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Author : Martin Clynes
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Animal Cell Culture Techniques written by Martin Clynes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Cell culture techniques allow a variety of molecular and cell biological questions to be addressed, offering physiological conditions whilst avoiding the use of laboratory animals. In addition to basic techniques, a wide range of specialised practical protocols covering the following areas are included: cell proliferation and death, in-vitro models for cell differentiation, in-vitro models for toxicology and pharmacology, industrial application of animal cell culture, genetic manipulation and analysis of human and animal cells in culture.
Cytotoxicity
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Author : Sonia Soloneski
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-09-15
Cytotoxicity written by Sonia Soloneski and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-15 with Medical categories.
This edited book, Cytotoxicity - New Insights into Toxic Assessment, is intended to present some strategies, methods, interpretations and recent advances in order to facilitate scientific research on in vitro toxic responses, presenting both theoretical and practical aspects.