In Vitro Toxicity Testing Protocols

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In Vitro Toxicity Testing Protocols

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Author : Sheila O’Hare
language : en
Publisher: Humana Press
Release Date : 2013-08-23

In Vitro Toxicity Testing Protocols written by Sheila O’Hare and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-23 with Medical categories.

In vitro toxicology is one of the most rapidly expanding areas of biological research today. It is generally conceded that this is a result of pressure from the public for safer products and environmental conditions and, in these recessionary times, pressure from company accountants, who often perceive in vitro experimentation as a cheaper option than lawsuits, fines, and expensive remediation. Toxicologists themselves form one group whose vigor and influence on the evolution of in vitro toxicology is often underestimated. Many toxicologists have for some time been unhappy with the quantity (often a result of unnecessary duplication), the reliability, and the ethical circumstances of much animal experimentation. It is hoped that the present book, In Vitro Toxicity Testing Protocols, will play some part in enabling and encouraging the more widespread use of in vitro techniques. Since in vitro toxicity testing methodology is evolving at such a rapid rate, this book can of necessity provide only a "snapshot" of the major techniques in use at the present time. As with the other publications in Humana Press' Methods in Molecular Biology series, the aim has been to supply information on the fundamental requirements for the establishment of new techniques within working laboratories and to describe a variety of basic in vitro methodologies. Certain of the techniques detailed here could more accurately be described as ex vivo rather than truly in vitro. No apology is made for the inclusion of these techniques.

In Vitro Toxicity Testing Protocols

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Author : Sheila O’Hare
language : en
Publisher: Humana Press
Release Date : 1995-05-04

In Vitro Toxicity Testing Protocols written by Sheila O’Hare and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-05-04 with Medical categories.

In Vitro Toxicity Testing Protocols is a collection of proven, state-of-the-art methods that toxicologists can use in carrying out laboratory studies. The book's expert contributors offer a variety of efficient in vitro toxicology techniques that can be applied regularly in your lab, or can serve as the fundamental basis for the establishment of novel techniques in working laboratories. All the procedures are highly reliable. Also included are ex vivo techniques, whose development embraces the twin aims of reduction and refinement of the use of laboratory animals; the editors believe this is an important step toward the ethical treatment of laboratory animals. In keeping with the successful format of preceding volumes of the Methods in Molecular Biology series, concise, easy-to-follow, step-by-step protocols are provided for each technique, together with extensive notes that cover troubleshooting and offer special tips to ensure the successful completion of your experiments.

In Vitro Toxicity Testing

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Author : John M. Frazier
language : en
Publisher: CRC Press
Release Date : 1992-01-31

In Vitro Toxicity Testing written by John M. Frazier and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-31 with Medical categories.

This volume focuses on the potential application of in vitro procedures to identify and quantify the toxicological risk to target organs associated with the use of commerical products and therapeutic drugs.;Revealing how the results of in vitro toxicity testing can be used in safety assessment, In Vitro Toxicity Testing: explores whether existing test methods can accomplish the necessary goals and, if not, what research is needed to make these techniques a practical reality; presents the current status of toxicity testing in the areas of hepatotoxicity, renal toxicity, ocular irritation, and many others; outlines the role of validation in technology transfer from the research laboratory to safety evaluation; examines testing strategies and regulatory acceptance and addresses common concerns about the ultimate utilization of available methods in chemical safety/hazard considerations; and analyzes the perspective of industrial and regulatory agencies on the application of in vitro toxicity testing.;Generously referenced with over 1400 literature citations, In Vitro Toxicity Testing is for academic, industrial, and regulatory toxicologists; applied, molecular, and cell biologists; pharmacologists; animal welfare activists; and graduate students in pharmacology and toxicology courses.

In Vitro Toxicology

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Author : Alok Dhawan
language : en
Publisher: Academic Press
Release Date : 2017-11-13

In Vitro Toxicology written by Alok Dhawan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-13 with Science categories.

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. - Discusses new techniques and protocols in a clear and concise manner - includes examinations of nanotoxicity, genotoxicity and carcinogenicity - Explains practical laboratory methods and the theories behind in vitro testing

Hayes Principles And Methods Of Toxicology

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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2014-10-10

Hayes Principles And Methods Of Toxicology written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-10 with Medical categories.

Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap

Principles And Methods Of Toxicology

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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2007-09-25

Principles And Methods Of Toxicology written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-25 with Medical categories.

Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanis

Information Resources In Toxicology

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Author : P.J. Bert Hakkinen
language : en
Publisher: Elsevier
Release Date : 2000-01-10

Information Resources In Toxicology written by P.J. Bert Hakkinen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01-10 with Medical categories.

Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added.This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. - Serves as an all-in-one resource for toxicology information - New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports - Updated to include the latest internet and electronic sources, e-mail addresses, etc. - Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects

In Vitro Methods In Pharmaceutical Research

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Author : Jose V. Castell
language : en
Publisher: Elsevier
Release Date : 1996-10-04

In Vitro Methods In Pharmaceutical Research written by Jose V. Castell and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-10-04 with Medical categories.

In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. - Meets the continuing demand for information in this field - Compares In Vitro techniques with other methods - Describes cell-culture methods used to investigate toxicity in cells derived from different organs - Includes contributions by leading experts in the field

Principles Of Toxicology Testing

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Author : Frank A. Barile
language : en
Publisher: CRC Press
Release Date : 2007-07-23

Principles Of Toxicology Testing written by Frank A. Barile and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-23 with Medical categories.

The evolution of toxicology testing finds its impetus in the continuing growth of the chemical and pharmaceutical industries, as well as the awareness of public health initiatives, needs, and responses that demand faster, more accurate, more economical methods for screening potential toxicity. Concurrent advances in biotechnology enable viable in v

In Vitro Toxicity Testing Protocols Methods In Molecular Biology

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Author : Christopher K. Atterwill
language : en
Publisher:
Release Date : 1995

In Vitro Toxicity Testing Protocols Methods In Molecular Biology written by Christopher K. Atterwill and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.

In Vitro Toxicity Testing Protocols is a collection of proven, state-of-the-art methods that toxicologists can use in carrying out laboratory studies. The book's expert contributors offer a variety of efficient in vitro toxicology techniques that can be applied regularly in your lab, or can serve as the fundamental basis for the establishment of novel techniques in working laboratories. All the procedures are highly reliable. Also included are ex vivo techniques, whose development embraces the twin aims of reduction and refinement of the use of laboratory animals; the editors believe this is an important step toward the ethical treatment of laboratory animals. In keeping with the successful format of preceding volumes of the Methods in Molecular Biology series, concise, easy-to-follow, step-by-step protocols are provided for each technique, together with extensive notes that cover troubleshooting and offer special tips to ensure the successful completion of your experiments.