In Vivo Cell Biology Of Cerebral Cortical Development And Its Related Neurological Disorders Cellular Insights Into Neurogenesis And Neuronal Migration
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In Vivo Cell Biology Of Cerebral Cortical Development And Its Related Neurological Disorders Cellular Insights Into Neurogenesis And Neuronal Migration
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Author : Takeshi Kawauchi
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-21
In Vivo Cell Biology Of Cerebral Cortical Development And Its Related Neurological Disorders Cellular Insights Into Neurogenesis And Neuronal Migration written by Takeshi Kawauchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-21 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders.
In Vivo Cell Biology Of Cerebral Cortical Development And Its Related Neurological Disorders Cellular Insights Into Neurogenesis And Neuronal Migration
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Author :
language : en
Publisher:
Release Date : 2016
In Vivo Cell Biology Of Cerebral Cortical Development And Its Related Neurological Disorders Cellular Insights Into Neurogenesis And Neuronal Migration written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders.
New Insights Into Adult Neurogenesis And Neurodegeneration Challenges For Brain Repair
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Author : Jose Angel Morales-Garcia
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-04
New Insights Into Adult Neurogenesis And Neurodegeneration Challenges For Brain Repair written by Jose Angel Morales-Garcia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-04 with Science categories.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1996
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medicine categories.
Cell Biology Of Brain Development And Evolution
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Author : Elena Taverna
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-20
Cell Biology Of Brain Development And Evolution written by Elena Taverna and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-20 with Science categories.
Novel Concepts In Ipsc Disease Modeling
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Author : Alexander Birbrair
language : en
Publisher: Academic Press
Release Date : 2022-01-08
Novel Concepts In Ipsc Disease Modeling written by Alexander Birbrair and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-08 with Science categories.
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson's disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. - Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics - Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson's disease, graft vs. host disease, and much more - Contributed by world-renown experts in the field
New Insights Into Schizophrenia Related Neural And Behavioral Phenotypes
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Author : Yuh-Man Sun
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-01
New Insights Into Schizophrenia Related Neural And Behavioral Phenotypes written by Yuh-Man Sun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-01 with Science categories.
Neuroprotection In Autism Schizophrenia And Alzheimer S Disease
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Author : Illana Gozes
language : en
Publisher: Academic Press
Release Date : 2019-10-16
Neuroprotection In Autism Schizophrenia And Alzheimer S Disease written by Illana Gozes and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-16 with Medical categories.
Neuroprotection in Autism, Schizophrenia and Alzheimer's Disease provides an up-to-date overview on recent clinical studies and the similarities discovered in the most prevalent brain disorders. The book's content will help shed light on basic mechanisms and provide new avenues for early diagnosis toward disease prevention and disease modification. It is written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry. Sections discuss the shared pathophysiological mechanisms that underlie autism, schizophrenia/mood disorders and Alzheimer's disease, i.e. neurodevelopmental disorders, neuropsychiatric diseases and neurodegenerative disorders. - Offers an up-to-date overview of basic and clinical studies concerning similarities in the most prevalent brain disorders - Helps the reader become familiar with novel neuroprotective mechanisms and experimental treatment modalities in these difficult to treat disorders - Written for researchers, clinicians and medical physicians in neuroscience, neurology and psychiatry
Cellular And Molecular Control Of Neuronal Migration
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Author : Laurent Nguyen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-18
Cellular And Molecular Control Of Neuronal Migration written by Laurent Nguyen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-18 with Medical categories.
Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.
Neuronal Polarity Establishment And Maintenance
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Author : Froylan Calderon de Anda
language : en
Publisher: Frontiers Media SA
Release Date : 2018-07-12
Neuronal Polarity Establishment And Maintenance written by Froylan Calderon de Anda and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-12 with categories.
The term polarity in a biological context is used to describe an asymmetry in morphology and distribution of molecules. In neurons, their complex shape with typically one axon and several dendrites reflects this asymmetry. Although neurons assume many different shapes and sizes they always maintain these two domains, which are essential for neuronal function. In the most simple view, neurons use their axon to transmit signals over long distances due to its capacity to extend to enormous lengths. Dendrites, on the other hand, are shorter and receive and integrate signals from different locations. The selection of the site where the axon and dendrites initially emerge during embryonic development is a tightly regulated event, eventually important for the correct formation of neuronal circuits, and disturbances of these processes can have pathological consequences due to circuit malformation. An important question is which mechanisms neurons utilize to specify the sites where axonal and dendrite outgrowth occurs and how their identities are maintained during and after development. The formation of these functionally diverse domains is the result of polarized differences of membrane and protein delivery, mitochondria transport, actin dynamics and microtubule stability. However how and in which temporal order all those events which coordinate the selection and maintenance of axons and dendrites is still under investigation. This selection of articles shall highlight new findings, which help to unravel all molecular and cellular events important for neuronal polarity establishment and maintenance.