Inflammasomes As Therapeutic Targets For Alzheimer S Disease
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Inflammasomes As Therapeutic Targets For Alzheimer S Disease
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Author :
language : en
Publisher:
Release Date : 2017
Inflammasomes As Therapeutic Targets For Alzheimer S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Therapeutic Targets For Alzheimer S Disease
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Author : Magdalena J. Kiprowska
language : en
Publisher:
Release Date : 2016
Therapeutic Targets For Alzheimer S Disease written by Magdalena J. Kiprowska and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Deciphering Drug Targets For Alzheimer S Disease
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Author : Dileep Kumar
language : en
Publisher: Springer Nature
Release Date : 2023-10-02
Deciphering Drug Targets For Alzheimer S Disease written by Dileep Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-02 with Medical categories.
This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.
Emerging Drugs And Targets For Alzheimer S Disease
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Author : Ana Martínez
language : en
Publisher: Royal Society of Chemistry
Release Date : 2010
Emerging Drugs And Targets For Alzheimer S Disease written by Ana Martínez and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
This volume describes the discovery and development history of promising drugs now in development for combating Alzheimer's disease.
Novel Compounds As Potential Alzheimer S Disease Therapeutics And Inhibitors Of The Nlrp3 Inflammasome
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Author : Jeremy E. Chojnacki
language : en
Publisher:
Release Date : 2014
Novel Compounds As Potential Alzheimer S Disease Therapeutics And Inhibitors Of The Nlrp3 Inflammasome written by Jeremy E. Chojnacki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Alzheimer's disease is a devastating neurodegenerative disorder and the leading cause of dementia. The disease manifests via several pathologies including neuroinflammation, oxidative stress, metal ion dyshomeostasis, and cell death. To address the multifaceted nature of this disorder, the design of several diverse compounds, targeting many pathological effects, was generated. First, a series of compounds based on curcumin and diosgenin were synthesized following the bivalent design strategy. Two compounds were discovered to have neuroprotective ability, anti-oxidative function, and anti-A[beta] oligomerization (A[beta]O) properties. A second set of molecules was also designed, wherein a hybrid compound strategy was utilized. Three hybrids were to shown to protect MC65 cells from A[beta]-induced toxicity and to have significant anti-oxidative activity. Mechanistic studies propose that protection is through disruption of interactions between A[beta]Os and partner proteins. Furthermore, one hybrid was also shown to be able to pass the BBB. Lastly, studies of glyburide, an anti-diabetic medication, have shown an off-target anti-inflammatory effect specific for the NLRP3 inflammasome, which has been implicated in AD development. Therefore, a series of glyburide analogs were synthesized and characterized. One analog was able to successfully inhibit the NLRP3 inflammasome and reduce IL-1[beta] expression without affecting blood glucose. In vivo studies demonstrated an ability to prevent or ameliorate adverse inflammation-related outcomes in murine inflammatory models. Altogether, these investigations have yielded three novel series of compounds, all capable of modifying Alzheimer's disease pathology. These results warrant future investigations into the development, optimization, and characterization of these analogs as potential treatments for Alzheimer's disease.
Resolution Of Inflammation As A Therapeutic Target For Alzheimer S Disease
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Author :
language : en
Publisher:
Release Date : 2015
Resolution Of Inflammation As A Therapeutic Target For Alzheimer S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Amyloid Precursor Protein Secretases
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Author : Kalpita J. Patel
language : en
Publisher:
Release Date : 2000
Amyloid Precursor Protein Secretases written by Kalpita J. Patel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Signaling Pathways Associated With Alzheimer S Disease And Possible Therapeutic Targets
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Author : Jason Schapansky
language : en
Publisher:
Release Date : 2013
Signaling Pathways Associated With Alzheimer S Disease And Possible Therapeutic Targets written by Jason Schapansky and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Nuclear Receptors As Therapeutic Targets For Alzheimer S Disease
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Author : Rebecca Courtney
language : en
Publisher:
Release Date : 2017
Nuclear Receptors As Therapeutic Targets For Alzheimer S Disease written by Rebecca Courtney and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Alzheimer's disease categories.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid beta (Aß) species in the brain. This is followed by robust neuroinflammation, the development of neurofibrillary tangles composed of tau, synaptic dysfunction, neuronal death, and the progressive development of cognitive and behavioral impairments. We demonstrate that nuclear receptors make useful therapeutic targets to address several aspects of this pathology. Using agonists for PPAR¿ and LXR, we show that a short-term treatment of 9 days is sufficient to ameliorate behavioral impairments, attenuate neuroinflammation, and induce partial clearance of Aß from the brain in an AD mouse model. This combination therapy acted on astrocytes to increase the expression and lipidation of apoE, and on microglia to increase their rate of Aß degradation and ability to associate with Aß plaques. We also demonstrate that some nuclear receptors, such as Nurr1, are valuable targets for addressing the neuronal pathology associated with AD. Knocking down Nurr111decreased the survival of vulnerable neurons in an AD mouse model. Conversely, increasing Nurr1 expression increased neuronal survival, decreased dystrophic neurites, and ameliorated local Aß pathology including decreasing intraneuronal Aß by about 30%. Together, these data demonstrate that drugs targeting multiple nuclear receptors can be valuable to treat various aspects of AD pathology. Interestingly, LXR, PPAR¿, and Nurr1 can all be activated by the RXR agonist bexarotene. These data provide insight into the mechanisms by which bexarotene might act, and suggest several novel therapeutic approaches to the treatment of AD.
Neuroinflammation In Alzheimer S Disease
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Author : Shenghua Zhu
language : en
Publisher:
Release Date : 2020
Neuroinflammation In Alzheimer S Disease written by Shenghua Zhu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.