Innate Lymphoid Cells In Cancer Friends Or Foes
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Innate Lymphoid Cells In Cancer Friends Or Foes
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Author : Nicolas Jacquelot
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-10
Innate Lymphoid Cells In Cancer Friends Or Foes written by Nicolas Jacquelot and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-10 with Medical categories.
Natural Killer Cells In Human Diseases Friends Or Foes
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Author : Vincent Vieillard
language : en
Publisher: Frontiers Media SA
Release Date : 2018-02-23
Natural Killer Cells In Human Diseases Friends Or Foes written by Vincent Vieillard and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-23 with categories.
NK cells are lymphocytes of the innate immune system that share some features with adaptive immune cells like T cells. They are well known for their importance to control viral infections and tumor development, but also intracellular bacterial and parasitic infections. A balance between negative and positive signals transmitted via germ line-encoded inhibitory and activating receptors controls the function of NK cells. Activated NK cells respond by killing the infected or tumor cells without prior sensitization, and by producing cytokines and chemokines. It has been shown that NK cells cross-talk with other immune cells, such as dendritic cells and macrophages, can shape T cell and B cell immune responses through direct interactions as well as by virtue of their cytokine/chemokine production. NK cells can also regulate immune responses by killing other immune cells, including activated T cells, or by producing anti-inflammatory cytokines upon excessive inflammation. However, NK cells are not friends in all situations. Indeed, it has been shown in LCMV-infected murine models that, depending on the viral inoculation load, NK cells may either help fight infection or can promote chronic infection. Moreover in cancer models, it has been shown that NK cells can kill anti-tumoral T cells. Recent studies of NK cells in patients with cancer support the notion of detrimental roles of NK cells. Furthermore, studies implicate NK cells in contributing to both graft rejection and tolerance to an allograft. In some autoimmune diseases, like rheumatoid arthritis, NK cells may promote disease pathogenesis. The scope of this Research Topic is to present and discuss knowledge on the role of NK cells in various diseases settings: viral infections as well as other infections, cancer, transplantation, and autoimmunity. The aim is to discuss how NK cells respond during disease and specifically when, why and how NK cells can be harmful and if they exert different functions (production of specific cytokines, inhibition of other immune cells through other mechanisms beside cytotoxicity) in these situations. Which are the NK cell subsets that play beneficial or deleterious roles in these diseases? Are there different phenotypes associated with protective NK cells (e.g. antiviral, antitumoral) and NK cells involved in disease pathogenesis? How are these diverse NK cells activated and do they function primarily through direct cytotoxicity, ADCC or cytokine and chemokine production? What are the signals or interactions that can change and shape the NK cell response shifting them from protective to harmful? We thank the authors that submitted reviews and original research manuscripts that help to better understand these questions, with the aim that this will help the scientific community to determine what could be the main future research directions to better understand the role of NK cells in disease protection or development.
Anesthesia And Cancer Friend Or Foe
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Author : Lucillia Bezu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-27
Anesthesia And Cancer Friend Or Foe written by Lucillia Bezu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-27 with Medical categories.
Molecular Strategies Aimed To Boost Nk Cell Based Immunotherapy Of Cancer
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Author : Loredana Cifaldi
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-31
Molecular Strategies Aimed To Boost Nk Cell Based Immunotherapy Of Cancer written by Loredana Cifaldi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-31 with categories.
In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.
In Memoriam Of Professor Alessandro Moretta
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Author : Eric Vivier
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-21
In Memoriam Of Professor Alessandro Moretta written by Eric Vivier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-21 with categories.
Natural Killer Cells In Tissue Compartments
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Author : Massimo Vitale
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-24
Natural Killer Cells In Tissue Compartments written by Massimo Vitale and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-24 with categories.
New Insights Into Innate Immune Cell Based Immunotherapies In Cancer
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Author : Mary Poupot-Marsan
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-17
New Insights Into Innate Immune Cell Based Immunotherapies In Cancer written by Mary Poupot-Marsan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-17 with Medical categories.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Immunotherapeutics
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Author : Rossen Donev
language : en
Publisher: Academic Press
Release Date : 2022-03-17
Immunotherapeutics written by Rossen Donev and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-17 with Science categories.
Immunotherapeutics, Volume 129 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Vaccines for the prophylaxis and treatment of HPV, Lung-targeted RNA-based therapeutics, Clostridium difficile: Current overview and future perspectives, Antivenoms for treatment of snake bites, Natural killer cell-based strategies for immunotherapy of cancer, Immunological insights of selectins in human disease mechanism, Current update, challenges, and future aspects of immunotherapeutics in non-small cell lung cancer, In silico interaction analysis of NEMO binding domain peptide on the NFkB protein, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Updated release includes the latest information on Immunotherapeutics
Alpha Fetoprotein And Its Receptor In Fixing The Cancer Brakes
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Author : Vladimir N. Pak
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2021-03-25
Alpha Fetoprotein And Its Receptor In Fixing The Cancer Brakes written by Vladimir N. Pak and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-25 with Science categories.
This book examines the crucial role of a unique alpha-fetoprotein (AFP) in the treatment of cancer. AFP can deliver toxins through specific receptors re-expressed in the majority of cancer cells, serving as a targeted chemotherapy. More importantly, AFP+toxin harnesses the patient’s immune system in order to attack cancer. Depleting the regulatory top monocyte-derived suppressor cells (MDSCs) activates both the innate and adaptive immune responses. The thoroughly chosen toxins switch on apoptosis in MDSCs, restore the broken one in cancer cells, and destroy them naturally without any harmful by-products. Injections with AFP+toxin preparations have shown promising results in animals and the treatment of cancer patients. In addition to this breakthrough, the book also discusses the peroral administration of porcine AFP non-covalent complexes with selected toxins in patients with metastases. It will appeal to science researchers, clinicians, and medical students, as well as the more general reader.