Natural Killer Cells In Tissue Compartments
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Natural Killer Cells In Tissue Compartments
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Author : Massimo Vitale
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-24
Natural Killer Cells In Tissue Compartments written by Massimo Vitale and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-24 with categories.
Supercharged Natural Killer Cells Preferentially Expand Cd8 Cytotoxic T Cells While Targeting Cd4 Helper T Cells
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Author : Narek Ohanian
language : en
Publisher:
Release Date : 2017
Supercharged Natural Killer Cells Preferentially Expand Cd8 Cytotoxic T Cells While Targeting Cd4 Helper T Cells written by Narek Ohanian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
NK mediated expansion of T-cells preferentially expands CD8+ but not the CD4+ subsets in both healthy and cancer donors. This results in a lower CD4/CD8 ratio. While NK Cells target CD4+ helper T-cells they do not target their CD8+ cytotoxic counterparts. This study also reveals that Cancer patients NK cells have reduced cytotoxic ability and secrete much less IFN- than healthy donors and Osteoclast and sAJ2 expanded super-charged NKs intended for immunotherapeutic use from healthy donors expand more immune cells at a faster rate. NK immunotherapy was studied in combination with supplementation of probiotic bacteria in the humanized mouse model. NK immunotherapy increased CD8+ cytotoxic T cell population in immune tissue compartments and Increased immune infiltration in the tumor microenvironment, while probiotic supplementation further enhanced these effects, resulting in decreased tumor burden. This novel expansion technique can provide a non-invasive and highly effective treatment for the treatment of oral squamous cell carcinoma and other tumorigenic cancers.
Supercharged Nk Cells Lyse Both Cscs Poorly Differentiated And Well Differentiated Tumors
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Author : Yash Jain
language : en
Publisher:
Release Date : 2023
Supercharged Nk Cells Lyse Both Cscs Poorly Differentiated And Well Differentiated Tumors written by Yash Jain and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Our previous research has shown that natural killer (NK) cells play a vital role as immune effectors in the selection and differentiation of various cancer stem cells and undifferentiated tumors. They achieve this through the direct killing and the release of IFN-[gamma] and TNF-[alpha], which inhibit tumor growth and curtail metastasis. Mechanistically, our studies have revealed that NK cells expanded by Osteoclasts display the ability to lyse CD4+ T cells while sparing CD8+ T cells, suggesting a potential selective effect of OC-activated NK cells on CD8+ T cell expansion. Consistent with these findings, we observed increased IFN-[gamma] secretion, NK cell-mediated cytotoxicity, and higher proportions of CD8+ T cells in various tissue compartments of oral tumor-bearing hu-BLT mice following immunotherapy with OC-expanded NK cells. In this study, we focused on investigating the lytic and differentiation capabilities of supercharged NK (sNK) cells in ovarian cancer cell lines (OVCAR 4 and OVCAR 8), oral cancer cell lines (OSCC and OSCSC), and a pancreatic cancer cell line (MP 2). Our results demonstrated that sNK cells exhibited greater lysing activity against both poorly differentiated and well differentiated tumors compared to pNK cells treated with IL-2. Furthermore, the supernatants of sNK cells exhibited significantly higher levels of IFN-[gamma] and induced differentiation by an increase in MHC class1 expressions in all the cell lines tested, except for OVCAR 8. Lastly, we observed a downmodulation of NKG2A and CD94 inhibitory receptors on sNK cells, suggesting potential alterations in their functional properties.
Natural Killer Cells
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Author : Michael T. Lotze
language : en
Publisher: Academic Press
Release Date : 2009-11-12
Natural Killer Cells written by Michael T. Lotze and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-12 with Medical categories.
Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells
Cancer Immunotherapy Principles And Practice Second Edition
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Author : Lisa H. Butterfield, PhD
language : en
Publisher: Springer Publishing Company
Release Date : 2021-08-25
Cancer Immunotherapy Principles And Practice Second Edition written by Lisa H. Butterfield, PhD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.
Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1989
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.
Nk Cell Subsets In Health And Disease New Developments
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Author : Emanuela Marcenaro
language : en
Publisher: Frontiers Media SA
Release Date : 2017-11-29
Nk Cell Subsets In Health And Disease New Developments written by Emanuela Marcenaro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-29 with Electronic book categories.
Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.
Lymphocyte Trafficking In Health And Disease
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Author : Raffaele Badolato
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-05
Lymphocyte Trafficking In Health And Disease written by Raffaele Badolato and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-05 with Medical categories.
This book deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. It offers a series of international contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease, and has a special focus on diseases and targets of therapeutical intervention. The book will interest researchers and clinicians from inflammation research.
Immunotoxicology
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Author : The Commission of the European Communities & UNEP, ILO, WHO International Programme on Chemical Safety
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunotoxicology written by The Commission of the European Communities & UNEP, ILO, WHO International Programme on Chemical Safety and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
IX The International Seminar on the Immunological System as a Target for Toxic Damage was held at The Commission of the European Communities (CEC) in Luxembourg on 6-9 November 1984. It was organized by the CEC and the International Programme on Chemical Safety of UNEP/ILO/WHO with the support of the u. S. Environmental Protection Agency and the National Institute of Environmental Health Sciences - USA and with the participation of the International Society of Immunophar macology. These bodies are actively concerned with the scientific and applied aspects of immunotoxicology. The Seminar consisted of thirty-four invited papers and three major panel discussions covering current and future test strategies for the screening of immunotoxic substances, hypersensitivity and the health implications of immunotoxico logical problems. It was attended by more than 200 scien tists from 27 countries representing all the Member states of the European Economic Community and the six Regions of the World Health Organization. These scientists represented many different disciplines and interests. The Seminar's principal objectives were: a review of recent advances in knowledge concerning the structure, function and dysfunction of the immunological system; - a review of the effects of xenobiotics on the immune system in animals and humans; an examination of the human health implications of immunotoxicity; discussion and critical analysis of the procedures for the assessment of immunological damage, a discussion of needs for the further development of laboratory and epidemiological methods and their validation, and a consideration of current test strategies.
Nutrition In Exercise And Sport Third Edition
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Author : Ira Wolinsky
language : en
Publisher: CRC Press
Release Date : 2022-01-28
Nutrition In Exercise And Sport Third Edition written by Ira Wolinsky and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-28 with Health & Fitness categories.
The third edition of Nutrition in Exercise and Sport has been updated and expanded to include the latest developments in the field. This third edition of a bestseller among sports nutrition and health professionals now fully discusses the role of exercise and nutrition in both wellness and in disease prevention. In addition, new chapters on the history of sports nutrition, antioxidants, vegetarianism, the young athlete, the older athlete, the diabetic athlete, the physically disabled athlete, sports specific nutrient requirements, and body composition changes have been added. Top sports nutrition practitioners and exercise scientists have contributed chapters that provide practical nutritional guidelines for those engaged in various types of physical performance. This book is a one-volume library on sports nutrition for research scientists in applied sports nutrition, dietitians, exercise physiologists, sports medicine physicians, coaches, trainers, athletes, and nutritionists. The first two editions of this book have been widely used in sports nutrition courses. Nutrition in Exercise and Sport is the standard in the field.
