Insights In Experimental Pharmacology And Drug Discovery 2021
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Insights In Experimental Pharmacology And Drug Discovery 2021
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Author : Salvatore Salomone
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-18
Insights In Experimental Pharmacology And Drug Discovery 2021 written by Salvatore Salomone and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-18 with Science categories.
Experimental And Computational Aspects Of Bioactive Proteins From Animal Venoms An Insight Into Pharmacological Properties And Drug Discovery
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Author : Michelle Yap
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-23
Experimental And Computational Aspects Of Bioactive Proteins From Animal Venoms An Insight Into Pharmacological Properties And Drug Discovery written by Michelle Yap and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-23 with Science categories.
Animal venoms are complex mixtures of bioactive peptides and proteins with diverse pharmacological effects. These active molecules make up the components of venom toxins responsible for many pathological outcomes in snake envenomation. Although venom toxins can be deadly, they can potentially be lifesaving once their respective pharmacological targets and mechanistic actions are better understood. For example, the discovery of captopril from Brazilian viper, Bothrops jararaca venom which has been shown to antagonise angiotensin-converting enzyme (ACE) for the treatment of hypertension.
Purinergic Signaling 2020 The State Of The Art Commented By The Members Of The Italian Purine Club
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Author : Francesco Caciagli
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-29
Purinergic Signaling 2020 The State Of The Art Commented By The Members Of The Italian Purine Club written by Francesco Caciagli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-29 with Science categories.
Managing The Drug Discovery Process
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Author : Susan Miller
language : en
Publisher: Elsevier
Release Date : 2023-03-09
Managing The Drug Discovery Process written by Susan Miller and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-09 with Medical categories.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
Basic Principles Of Drug Discovery And Development
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Author : Benjamin E. Blass
language : en
Publisher: Academic Press
Release Date : 2021-03-30
Basic Principles Of Drug Discovery And Development written by Benjamin E. Blass and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-30 with Medical categories.
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry
Model Informed Decision Making In The Preclinical Stages Of Pharmaceutical Research And Development
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Author : Rui Li
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-10
Model Informed Decision Making In The Preclinical Stages Of Pharmaceutical Research And Development written by Rui Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-10 with Science categories.
Epigenetic Mechanisms And Post Translational Modifications As Novel Therapeutic Targets In Cancer
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Author : Yi-Chao Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-21
Epigenetic Mechanisms And Post Translational Modifications As Novel Therapeutic Targets In Cancer written by Yi-Chao Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-21 with Science categories.
Drug Discovery And Evaluation Pharmacological Assays
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Author : Hans Vogel
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-30
Drug Discovery And Evaluation Pharmacological Assays written by Hans Vogel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-30 with Medical categories.
The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
The Pharmacology Of Kratom And Its Alkaloids
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Author : Oliver Grundmann
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-28
The Pharmacology Of Kratom And Its Alkaloids written by Oliver Grundmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-28 with Science categories.
Chemoinformatics Approaches To Structure And Ligand Based Drug Design Volume Ii
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Author : Adriano D. Andricopulo
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-27
Chemoinformatics Approaches To Structure And Ligand Based Drug Design Volume Ii written by Adriano D. Andricopulo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-27 with Science categories.