Insights In Statistical Genetics And Methodology 2022
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Insights In Statistical Genetics And Methodology 2022
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Author : Simon Charles Heath
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-24
Insights In Statistical Genetics And Methodology 2022 written by Simon Charles Heath and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-24 with Science categories.
This Research Topic is part of the Insights in Frontiers in Genetics series.
Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants
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Author : Yuan-Ming Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26
Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants written by Yuan-Ming Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.
Genome-wide association studies (GWAS) have been widely used in the genetic dissection of complex traits. However, there are still limits in current GWAS statistics. For example, (1) almost all the existing methods do not estimate additive and dominance effects in quantitative trait nucleotide (QTN) detection; (2) the methods for detecting QTN-by-environment interaction (QEI) are not straightforward and do not estimate additive and dominance effects as well as additive-by-environment and dominance-by-environment interaction effects, leading to unreliable results; and (3) no or too simple polygenic background controls have been employed in QTN-by-QTN interaction (QQI) detection. As a result, few studies of QEI and QQI for complex traits have been reported based on multiple-environment experiments. Recently, new statistical tools, including 3VmrMLM, have been developed to address these needs in GWAS. In 3VmrMLM, all the trait-associated effects, including QTN, QEI and QQI related effects, are compressed into a single effect-related vector, while all the polygenic backgrounds are compressed into a single polygenic effect matrix. These compressed parameters can be accurately and efficiently estimated through a unified mixed model analysis. To further validate these new GWAS methods, particularly 3VmrMLM, they should be rigorously tested in real data of various plants and a wide range of other species.
Mathematical And Statistical Methods For Genetic Analysis
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Author : Kenneth Lange
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mathematical And Statistical Methods For Genetic Analysis written by Kenneth Lange and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
During the past decade, geneticists have cloned scores of Mendelian disease genes and constructed a rough draft of the entire human genome. The unprecedented insights into human disease and evolution offered by mapping, cloning, and sequencing will transform medicine and agriculture. This revolution depends vitally on the contributions of applied mathematicians, statisticians, and computer scientists. Mathematical and Statistical Methods for Genetic Analysis is written to equip students in the mathematical sciences to understand and model the epidemiological and experimental data encountered in genetics research. Mathematical, statistical, and computational principles relevant to this task are developed hand in hand with applications to population genetics, gene mapping, risk prediction, testing of epidemiological hypotheses, molecular evolution, and DNA sequence analysis. Many specialized topics are covered that are currently accessible only in journal articles. This second edition expands the original edition by over 100 pages and includes new material on DNA sequence analysis, diffusion processes, binding domain identification, Bayesian estimation of haplotype frequencies, case-control association studies, the gamete competition model, QTL mapping and factor analysis, the Lander-Green-Kruglyak algorithm of pedigree analysis, and codon and rate variation models in molecular phylogeny. Sprinkled throughout the chapters are many new problems.
Statistical Genomics
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Author : Brooke Fridley
language : en
Publisher: Springer Nature
Release Date : 2023-03-16
Statistical Genomics written by Brooke Fridley and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-16 with Science categories.
This volume provides a collection of protocols from researchers in the statistical genomics field. Chapters focus on integrating genomics with other “omics” data, such as transcriptomics, epigenomics, proteomics, metabolomics, and metagenomics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Statistical Genomics hopes that by covering these diverse and timely topics researchers are provided insights into future directions and priorities of pan-omics and the precision medicine era.
Advancement In Gene Set Analysis Gaining Insight From High Throughput Data
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Author : Farhad Maleki
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-01
Advancement In Gene Set Analysis Gaining Insight From High Throughput Data written by Farhad Maleki and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-01 with Science categories.
Statistical Methods And Applications In Systems Assurance And Quality
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Author : Sotiris Bersimis
language : en
Publisher: CRC Press
Release Date : 2025-10-03
Statistical Methods And Applications In Systems Assurance And Quality written by Sotiris Bersimis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-10-03 with Mathematics categories.
In the era of big data and real-time monitoring, vast amounts of information are generated every second through sensors and advanced tracking systems. The information contained in the data needs to be carefully analyzed and accurate results must be delivered to the users as soon as possible. This book explores the critical role of statistics in modern technologies and applied sciences such as health, informatics, and production systems. Statistical Methods and Applications in Systems Assurance and Quality provides a comprehensive overview of statistical methods for ensuring system quality and reliability. It discusses best practices for improving the quality of manufacturing products by using proper statistical methods. The book covers the current state of statistical methods used for system quality and conveys the importance of healthcare systems and employing statistics in the detection of epidemic outbreaks. Designed for researchers, industry professionals, and academics, this reference is ideal for those working in manufacturing, healthcare, computer engineering, statistical process control, and machine learning applications. It serves as a valuable resource for anyone seeking to enhance system performance through data-driven insights.
Handbook Of Statistical Genetics
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Author : David J. Balding
language : en
Publisher: John Wiley & Sons
Release Date : 2008-06-10
Handbook Of Statistical Genetics written by David J. Balding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-10 with Science categories.
The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.
Developmental Psychopathology
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Author : Jim Stevenson
language : en
Publisher: Springer Nature
Release Date : 2023-11-16
Developmental Psychopathology written by Jim Stevenson and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-16 with Psychology categories.
This book addresses the question of whether or not behavioural differences between children can be most appropriately characterised by dimensions of psychological problems or by categorical diagnoses. It describes the concepts and methods that have been developed and applied within developmental psychopathology using this dimensional approach. The book reviews evidence on the interplay between genes and the environment in influencing internalising problems, externalising problems, Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD), and on the hierarchical factor structure underlying these behavioural dimensions. It provides an appraisal of the state of knowledge on the longer-term sequelae of these problems and on the efficacy of treatments that have been developed for them.Key areas of coverage include: Multivariate data analytic methods for investigating behavioural differences (e.g., path analysis, cluster analysis, structural equation modelling, network analysis) and their associated theoretical frameworks (e.g., hierarchical factor models). Methods to investigate the biology of behavioural differences (e.g., quantitative and molecular genetics, epigenetics, and brain imaging). The design of research studies that can test most directly for causality (i.e., randomised controlled trials) and others that can estimate plausible causal relationships from associations and correlations. Reviews of studies that have applied these methods to understand the developmental course of internalising and externalising behaviours and the neurodevelopmental problems of Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). Developmental Psychopathology is an essential reference for researchers, professors, and graduate students as well as clinicians and other professionals in developmental psychology, clinical child and school psychology, child and adolescentpsychiatry, paediatrics, clinical social work, public health, educational psychology, and all related disciplines.
Insights In Functional And Applied Plant Genomics 2023
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Author : Huihui Li
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-21
Insights In Functional And Applied Plant Genomics 2023 written by Huihui Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-21 with Science categories.
We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of plant science. Frontiers has organized a series of Research Topics to highlight the latest advancements in research across the field of plant science, with articles from the Associate Members of our accomplished Editorial Boards. This editorial initiative of particular relevance, led by Dr. Huihui Li, Specialty Chief Editor of the Functional and Applied Plant Genomics section, is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of Functional and Applied Plant Genomics. The Research Topic solicits brief, forward-looking contributions from the editorial board members that describe the state of the art, outlining, recent developments and major accomplishments that have been achieved and that need to occur to move the field forward. Authors are encouraged to identify the greatest challenges in the sub-disciplines, and how to address those challenges. The goal of this special edition Research Topic is to shed light on the progress made in the past decade in the field of Functional and Applied Plant Genomics, and on its future challenges to provide a thorough overview of the field. This article collection will inspire, inform and provide direction and guidance to researchers in the field. We welcome original research, reviews, perspective, and thought-provoking opinion to this Research Topic.
Intelligent Solutions For Cognitive Disorders
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Author : Jadhav, Dipti
language : en
Publisher: IGI Global
Release Date : 2024-02-14
Intelligent Solutions For Cognitive Disorders written by Jadhav, Dipti and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-14 with Medical categories.
Cognitive disorders are a growing concern, affecting individuals across the age spectrum and society. These disorders can profoundly disrupt daily life, and their timely diagnosis is crucial for effective intervention and care. As the prevalence of cognitive disorders continues to rise, the need for precise and early diagnosis has never been more pressing. Intelligent Solutions for Cognitive Disorders is a research-based book which delves into the intersection of medical science and technology, exploring the latest advancements in cognitive disorder diagnosis and treatment. This book assembles a multidisciplinary team of experts, including researchers, clinicians, and technologists, to address this challenge head-on. This book commences with an in-depth introduction to cognitive disorders, providing a solid foundation for readers of all backgrounds. It then navigates the role of intelligent systems in cognitive healthcare, unveiling the potential of artificial intelligence, machine learning, and deep learning techniques. The book highlights how these intelligent systems can enable the early and accurate detection of cognitive disorders, a pivotal factor in improving patients' quality of life. This book is an invaluable resource for technologists, researchers, linguists, data scientists, healthcare practitioners, medical professionals, and students seeking a comprehensive understanding of cognitive disorders and the role of intelligent technologies in their diagnosis and care.