Interferons And Their Applications
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Interferons And Their Applications
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Author : P.E. Came
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Interferons And Their Applications written by P.E. Came and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances. Many also feel these polypeptides will prove invaluable probes in unraveling certain fundamental biochemical processes which control the life cycle and developmental pattern of many human cells. In contrast, only a year or two ago, this optimism had given way to an attitude almost of disenchantment as public and scientific expectations were raised steeply, then rapidly waned, as it turns out, prematurely. Both the mUltiple actions of interferons (a virtual cascade of biochemical reactions may be induced, as documented herein) and the high visibility of interferon research provided by the millions of dollars invested both by national health agencies and by multinational pharmaceutical companies, contributed to an upsweep in public attention to drug development probably unprecedented in this century. Virtually every oncologist, it would seem, was plagued by requests for the experimental agent, although they already had therapies of more proven value. As recently as 1980, even though interferon had achieved success against certain cancers and certain viral diseases, the variability in clinical results was seemingly ever present and little evidence emerged to suggest interferons could cure advanced diseases. Why then the resurgence of an optimistic mood? There are almost always many elements which contribute to happiness, and this is certainly true of the broad frontier of interferon and its place in biochemical research and treatment.
Clinical Application Of Interferons And Their Inducers
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Author : Dale A. Stringfellow
language : en
Publisher: Marcel Dekker
Release Date : 1986
Clinical Application Of Interferons And Their Inducers written by Dale A. Stringfellow and has been published by Marcel Dekker this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
Interferons Mechanisms Of Action And Role In Cancer Therapy
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Author : Derek Crowther
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Interferons Mechanisms Of Action And Role In Cancer Therapy written by Derek Crowther and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A great deal of new information has been obtained during the past four years, and this monograph provides a clear and well reviewed update on biochemical mechanisms and the results of important new clinical studies using the interferons. Reviews include what is presently known about the biosynthesis, physiological role and mechanisms of action of the interferons (alpha, beta, gamma). New biochemical information on interferon-receptor interactions and signalling pathways is provided. The pharmacokinetic considerations in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and other solid tumors are reviewed with special emphasis on studies of adjuvant chemotherapy in malignancies of the immune system.
Case For Interferon
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Author : Joseph Cummins
language : en
Publisher: Simon and Schuster
Release Date : 2021-01-05
Case For Interferon written by Joseph Cummins and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-05 with Science categories.
Touted as a potential breakthrough cancer therapy in the 1980s by the scientific community and publications such as TIME and Newsweek magazine, the reputation of interferon has not lived up to its early promise. Interferons are small proteins with anti-viral and anti-cancer effects, which have the power to modulate the functioning of the immune system. But Dr. Joseph Cummins, an early interferon pioneer, holder of sixteen US medical patents, author of more than sixty scientific publications, as well as having taught veterinary medicine at the University of Missouri, University of Illinois, and Texas A & M University, argues that the current thinking on interferon is fundamentally flawed. Interferon is created in small quantities in the body in response to infection, and seems to work best at these low dosages. However, the public health cowboys, working under the assumption that anything good in tiny amounts must be better in massive amounts, pursued exactly the wrong strategy. High-dose interferon does not work in the body and may even cause problems. The first remarkable results for interferon and the flu were reported by the Soviets in the 1970s, but Western medicine discounted these findings because they believed the dosages were so low they couldn’t possibly be effective. In the 1980s, when interferon was expensive to produce and only small quantities could be manufactured, the results were remarkable. Dr. Cummins was an early pioneer of low-dose interferon, and his remarkable findings among animals led to collaborations with medical doctors for human trials, even going so far as Africa at the height of the HIV-AIDS epidemic. Cummins reviews the evidence for this inexpensive, safe treatment and makes an eloquent argument for medical science to take another look at interferon to tackle today’s most challenging health conditions, including COVID-19.
Cytokines Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Cytokines Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.
Cytokines—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cytokines. The editors have built Cytokines—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cytokines in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cytokines—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Advances In Interferon Type I Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Advances In Interferon Type I Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
Advances in Interferon Type I Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Interferon Type I. The editors have built Advances in Interferon Type I Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Interferon Type I in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Interferon Type I Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Cytokines In The Nervous System
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Author : Nancy J. Rothwell
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Cytokines In The Nervous System written by Nancy J. Rothwell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
The Interferon System
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Author : W.E. Stewart II
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
The Interferon System written by W.E. Stewart II and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
This book is an update of Interferon, published in 1969 by Dr. Jan Vilcek. The field of interferon research has since expanded from its former narrow treatment of interferon strictly as an antiviral substance, such that The Interferon System now encompasses cellular modulations ranging from immune alterations to cell proliferative restrictions to antitumor activities. The steadily increasing number of these non-antiviral functions of interferons emphasizes the need for a comprehensive - and critical - review of the entire literature of interferon studies. The text, with its supporting bibliography, provides complete coverage of interferon research. A newcomer to the area should find here all the informa tion necessary to understand why interferon, which has been studied for more than twenty years and which originally stirred excitement over its clinical pros pects, is still inspiring speculation about this potential. For those already fa miliar with the seemingly perpetual clinical promise of interferon, this volume should serve as a valuable reference source, the largest bibliography on the subject ever to appear under one cover. Clearly, this book should be considered only as an introduction to the topic and as a reference source; most questions about the interferon system are still unanswered - even unasked. Hopefully this summation and critical evalua tion of work done to date will stimulate and facilitate further progress. William E. Stewart II New York, N. Y., February 1979 Contents I. Introduction ............................................................. .
Interferons
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Author : Carlo Aul
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Interferons written by Carlo Aul and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Interferons were among the first cytokines to be studied clinically in recombinant form in the 1980s, beginning a new era of pharmacotherapy in internal medicine. Interferons were soon employed in the treatment of tumors and it was shown that those hematopoietic neoplasias which had been difficult to treat with chemotherapy responded well to interferon treatment. In the present volume, renowned international authors update the importance of interferons in various fields of internal medicine, dermatology, and urology. The book also contains a general introduction into the classification, structure, and mode of action of interferons. Further chapters discuss the range of side effects of these substances and point out possible focuses of further clinical interferon research.
Cytokines Advances In Research And Application 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21
Cytokines Advances In Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Science categories.
Cytokines—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Osteopontin. The editors have built Cytokines—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Osteopontin in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cytokines—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.