Interleukin Protocols
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Interleukin Protocols
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Author : Luke A. J. O’Neill
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Interleukin Protocols written by Luke A. J. O’Neill and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
Interleukins are a family of proteins that regulate the maturation, diff- entiation, or activation of cells involved in immunity and inflammation, and belong to a broader family termed cytokines. Collectively these proteins are the key orchestrators of host defense and the response to tissue injury. There are currently 23 different interleukins (numbered from IL-1 to IL-23), although the full extent of the interleukin family will only become clear upon analysis of the human genome sequence. Most important, interleukins are central to the pathogenesis of a wide range of diseases that involve an immune com- nent, including such conditions as rheumatoid arthritis, multiple sclerosis, ulcerative colitis, psoriasis, and asthma. Interleukins have also been imp- cated in other conditions, including cancer, migraine, myocardial infarction, and depression. In essence, when cells are activated by interleukins, a program of gene expression is initiated in the target cell that alters the cell’s phenotype, leading to enhanced immune reactivity, inflammation, and/or proliferation. Interleukins are therefore at the core of the cellular basis for many diseases. They are the subject of intense investigation by biomedical researchers and the targeting or use of interleukins in the clinic is proceeding apace. Approaches such as t- geting IL-4 in asthma or IL-1 in joint disease are being pursued, and it is likely that in the next 5–10 years a number of new therapies based on either inhib- ing or administering interleukins will be available.
Cytokine Protocols
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Author : Marc De Ley
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Cytokine Protocols written by Marc De Ley and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Medical categories.
A collection of biochemical, cellular, and molecular techniques for unraveling and quantifying the events occurring between the initial contact of a cytokine at the membrane receptor and the eventual activation of gene transcription. The techniques used include the generation of transfectants, the immunohistochemical detection of cytokines in tissue sections, and optimized staining for cytoplasmic detection. Highlights include RT-PCR of small amounts of mRNA, in situ hybridization, biosensor analysis, measurement of biological activities and standardization, immunohistochemical and single-cell detection, and receptor isolation, characterization, and crystallization. Enjoy a quick and smooth introduction to the key methods used in cytokine research Use readily reproducible techniques that ensure successful experimental results Employ antisense-RNA, RT-PCR of small amounts of mRNA, and in situ hybridization.
Interleukin 10 In Health And Disease
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Author : Simon Fillatreau
language : en
Publisher: Springer
Release Date : 2014-07-08
Interleukin 10 In Health And Disease written by Simon Fillatreau and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.
Interleukins
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Author : Payam Behzadi
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-07-14
Interleukins written by Payam Behzadi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-14 with Medical categories.
The immune system recruits a wide range of molecule groups and categories, each of which has its own function, property, and structure. Among these, interleukins play a pivotal role in supporting the immune and non-immune systems of the human body. Interleukins as effective cytokines participate in different conditions such as homeostasis, infectious diseases, autoimmune diseases, and cancers. This unique property of interleukins makes them invaluable biomarkers that can be used as important biosensors. This book is divided into three sections: “Interleukins’ Classification and Evolutionary Features”, “Autoimmune Diseases and Low Immune System”, and “Cancer and Injuries”. Chapters examine the role of various interleukins in conditions such as leukemia, rheumatoid arthritis, and allergic and autoimmune diseases.
The Interleukins
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Author : Steven Gillis
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
The Interleukins written by Steven Gillis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
Investigations of the activation, proliferation, and, in some cases, differentia tion of mononuclear cells involved in the immune response are proceeding rapidly. These studies have resulted in the discovery of several factors that promote these cellular events, some of which have been characterized biochemically to various extents. Because of the considerable interest in understanding these cellular changes at the molecular level, we chose to produce the first thematic volume for Contemporary Topics in Molecular Immunology; the theme deals with certain regulatory factors that promote proliferation and differentiation. We have com piled contributions from numerous scientists well known for their work with several regulatory factors. In the following paragraphs, the reader will find an overview of the contents of this volume. Greene and Robb review data they have generated over the past 2-3 years with respect to characterization of hormone-specific Interleukin-2 (IL-2) recep tors on the surface of activated T cells. Their chapter traces the development of a quantitative assay for assessment of IL-2 receptors based on the preparation and use of radiolabeled IL-2 prepared biosynthetically with the aid of IL-2-pro ducer leukemic cells. The authors then describe an alternate approach, the prep aration of a monoclonal antibody previously determined to be directed against a T -cell-activation antigen. This so-called anti-Tac antibody was later found to recognize a determinant on or near the IL-2 receptor.
Interleukin 8 Nap 1 And Related Chemotactic Cytokines
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Author : Marco Baggiolini
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1992
Interleukin 8 Nap 1 And Related Chemotactic Cytokines written by Marco Baggiolini and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
Interleukin 10
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Author : Jan E.de Vries
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Interleukin 10 written by Jan E.de Vries and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The presented information reflects a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and will contribute to our understanding of the role of ILj-10 in the immune system and its potential clinicial utility in the near future. The book contains chapters in which the in vitro biological effects of IL-10 on both mouse and human lymphoid and myeloid cells are reviewed. In addition, the role of IL-10 in transplantation, parasite infections, inflammation, infectious diseases and bone formation is described. The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.
Interleukin 6 Type Cytokines
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Author : Andrzej Mackiewicz
language : en
Publisher:
Release Date : 1995
Interleukin 6 Type Cytokines written by Andrzej Mackiewicz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
This volume discusses the role of interleukin-6-type cytokines in haematopoietic cell proliferation, neuronal differentiation and acute phase response to inflammation. New data is presented concerning the structure and function of interleukin-6, the leukemia inhibitory factor, interleukin-11, oncostatin M and the ciliary neurotrophic factor. Also discussed is cytokine receptor function, common signal transduction mechanisms, the molecular basis of cytokine-mediated alterations in gene expression, and regulation of cell proliferation. Pre-clinical and clinical studies with these cytokines are evaluated.
Interleukin 10
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Author : Francesco M. Marincola
language : en
Publisher: CRC Press
Release Date : 2006-01-26
Interleukin 10 written by Francesco M. Marincola and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-26 with Science categories.
Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-t
Inflammation And Cancer
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Author : Brendan J. Jenkins
language : en
Publisher: Springer Nature
Release Date : 2023-06-24
Inflammation And Cancer written by Brendan J. Jenkins and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-24 with Medical categories.
This second edition volume expands on the previous edition with an update on the broad spectrum of research models, techniques, and protocols used in laboratories by basic and clinical researchers. The chapters in this book are divided into two parts. Part One discusses the latest findings on the development and characterization of representative research models for chronic immune-based diseases and inflammation-associated cancers. Part Two covers biochemical, molecular, and cellular biological techniques that are commonly used to dissect the molecular mechanisms and cellular processes that drive the pathogenesis of certain disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Inflammation and Cancer: Methods and Protocols, Second Edition is a valuable resource for those with a diverse range of laboratory-based experience, ranging from novice undergraduate students to established basic or clinical researchers who wish to diversify their existing portfolio of practical knowledge in the field.
