Lead Seeking Approaches
DOWNLOAD
Download Lead Seeking Approaches PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Lead Seeking Approaches book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Lead Seeking Approaches
DOWNLOAD
Author : Matthew M. Hayward
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-12
Lead Seeking Approaches written by Matthew M. Hayward and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-12 with Science categories.
High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi?ed from one or more of these screening methods, they need to be thoroughly characterized in order to con?rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi?ed, preliminary optimization through synthetic modi?cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef?cient approach to the identi?cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi?- tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci?c points. There are also a number of excellent reviews covering the lead identi?cation process [1–6].
Lead Generation Approaches In Drug Discovery
DOWNLOAD
Author : Zoran Rankovic
language : en
Publisher: John Wiley & Sons
Release Date : 2010-04-07
Lead Generation Approaches In Drug Discovery written by Zoran Rankovic and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-07 with Medical categories.
An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Modeling The Effectiveness Of The Lead Farmer Approach In Agricultural Extension Service Provision Nationally Representative Panel Data Analysis In Malawi
DOWNLOAD
Author : Ragasa, Catherine
language : en
Publisher: Intl Food Policy Res Inst
Release Date : 2019-06-14
Modeling The Effectiveness Of The Lead Farmer Approach In Agricultural Extension Service Provision Nationally Representative Panel Data Analysis In Malawi written by Ragasa, Catherine and has been published by Intl Food Policy Res Inst this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-14 with Political Science categories.
The lead farmer (LF) approach has been implemented and heavily promoted nationwide in Malawi since 2009 to support government extension workers and accelerate technology dissemination. Earlier reports have shown that donor-funded projects in Malawi widely adopted the LF approach, indicating positive roles and contributions of LFs. However, national data show persistently low rates of adoption of management practices being promoted by the LFs, prompting this study to look closely at the nationwide implementation and effectiveness of the LF approach. Specifically, we model the effects of farmers’ interaction with and exposure to LFs and farmers’ access to LFs’ advice on farmers’ awareness of and adoption of several promoted technologies and management practices. We use data from 531 randomly selected LFs linked to panel data from 2,800 farming households and, using correlated random effects, model the effectiveness of the LF approach on technology awareness and adoption. This is complemented by 55 focus group discussions and in-depth interviews with agricultural extension development officers (AEDOs) and service providers. Our results point to two major conclusions. First, LFs support and assist AEDOs in their work, especially in organizing community meetings and farm demonstrations, and are also an important bridge between farmers and AEDOs. But LFs complement AEDOs’ work rather than substitute for it. In communities without strong AEDOs and community leaders to work with and monitor them, LFs were not active or performed at a substandard level. Second, results show limited coverage and weak implementation and effectiveness of the LF approach at the national level. Only 13 percent of farmers reported receiving agricultural advice from an LF in the last two years, and only 20 percent reported having interacted with an LF. Our econometric models also consistently show neither the farmers’ exposure or interaction with LFs nor farmers’ access to LFs’ advice had an effect on awareness of and adoption of the major agricultural management practices being promoted. When heterogeneity and types of LFs are unpacked, results show that quality of LFs, adoption behavior of LFs, and regular training of LFs have strong and consistent effect on the awareness and adoption of most agricultural practices promoted.
Nasa Technical Memorandum
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 1991
Nasa Technical Memorandum written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Aeronautics categories.
Peacebuilding Conflict And Community Development
DOWNLOAD
Author : John Eversley
language : en
Publisher: Policy Press
Release Date : 2022-11-28
Peacebuilding Conflict And Community Development written by John Eversley and has been published by Policy Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-28 with Political Science categories.
How do local communities effectively build peace and reconciliation before, during and after open violence? This trailblazing book gives practical examples, from the Global North, the former Soviet bloc and Global South, on communities addressing conflict in divided and contested societies. The book draws on a range of critical perspectives and practitioner analyses. The diverse case studies demonstrate the considerable knowledge, skills, commitment, courage and relationships within local communities that a critical community development approach can support and encourage. Concluding with activists’ perspectives on working with the challenges of violence, the book offers insights for both an understanding of the root causes of conflict and for bottom-up peacebuilding.
Safety And Health For Engineers
DOWNLOAD
Author : Roger L. Brauer
language : en
Publisher: John Wiley & Sons
Release Date : 2022-08-18
Safety And Health For Engineers written by Roger L. Brauer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-18 with Technology & Engineering categories.
SAFETY AND HEALTH FOR ENGINEERS A comprehensive resource for making products, facilities, processes, and operations safe for workers, users, and the public Ensuring the health and safety of individuals in the workplace is vital on an interpersonal level but is also crucial to limiting the liability of companies in the event of an onsite injury. The Bureau of Labor Statistics reported over 4,700 fatal work injuries in the United States in 2020, most frequently in transportation-related incidents. The same year, approximately 2.7 million workplace injuries and illnesses were reported by private industry employers. According to the National Safety Council, the cost in lost wages, productivity, medical and administrative costs is close to 1.2 trillion dollars in the US alone. It is imperative—by law and ethics—for engineers and safety and health professionals to drive down these statistics by creating a safe workplace and safe products, as well as maintaining a safe environment. Safety and Health for Engineers is considered the gold standard for engineers in all specialties, teaching an understanding of many components necessary to achieve safe workplaces, products, facilities, and methods to secure safety for workers, users, and the public. Each chapter offers information relevant to help safety professionals and engineers in the achievement of the first canon of professional ethics: to protect the health, safety, and welfare of the public. The textbook examines the fundamentals of safety, legal aspects, hazard recognition and control, the human element, and techniques to manage safety decisions. In doing so, it covers the primary safety essentials necessary for certification examinations for practitioners. Readers of the fourth edition of Safety and Health for Engineers readers will also find: Updates to all chapters, informed by research and references gathered since the last publication The most up-to-date information on current policy, certifications, regulations, agency standards, and the impact of new technologies, such as wearable technology, automation in transportation, and artificial intelligence New international information, including U.S. and foreign standards agencies, professional societies, and other organizations worldwide Expanded sections with real-world applications, exercises, and 164 case studies An extensive list of references to help readers find more detail on chapter contents A solution manual available to qualified instructors Safety and Health for Engineers is an ideal textbook for courses in safety engineering around the world in undergraduate or graduate studies, or in professional development learning. It also is a useful reference for professionals in engineering, safety, health, and associated fields who are preparing for credentialing examinations in safety and health.
Ending Discrimination Against People With Mental And Substance Use Disorders
DOWNLOAD
Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-09-03
Ending Discrimination Against People With Mental And Substance Use Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-03 with Social Science categories.
Estimates indicate that as many as 1 in 4 Americans will experience a mental health problem or will misuse alcohol or drugs in their lifetimes. These disorders are among the most highly stigmatized health conditions in the United States, and they remain barriers to full participation in society in areas as basic as education, housing, and employment. Improving the lives of people with mental health and substance abuse disorders has been a priority in the United States for more than 50 years. The Community Mental Health Act of 1963 is considered a major turning point in America's efforts to improve behavioral healthcare. It ushered in an era of optimism and hope and laid the groundwork for the consumer movement and new models of recovery. The consumer movement gave voice to people with mental and substance use disorders and brought their perspectives and experience into national discussions about mental health. However over the same 50-year period, positive change in American public attitudes and beliefs about mental and substance use disorders has lagged behind these advances. Stigma is a complex social phenomenon based on a relationship between an attribute and a stereotype that assigns undesirable labels, qualities, and behaviors to a person with that attribute. Labeled individuals are then socially devalued, which leads to inequality and discrimination. This report contributes to national efforts to understand and change attitudes, beliefs and behaviors that can lead to stigma and discrimination. Changing stigma in a lasting way will require coordinated efforts, which are based on the best possible evidence, supported at the national level with multiyear funding, and planned and implemented by an effective coalition of representative stakeholders. Ending Discrimination Against People with Mental and Substance Use Disorders: The Evidence for Stigma Change explores stigma and discrimination faced by individuals with mental or substance use disorders and recommends effective strategies for reducing stigma and encouraging people to seek treatment and other supportive services. It offers a set of conclusions and recommendations about successful stigma change strategies and the research needed to inform and evaluate these efforts in the United States.
Handbook Of Temperament
DOWNLOAD
Author : Marcel Zentner
language : en
Publisher: Guilford Press
Release Date : 2012-07-26
Handbook Of Temperament written by Marcel Zentner and has been published by Guilford Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-26 with Psychology categories.
Timely and authoritative, this unique handbook explores the breadth of current knowledge on temperament, from foundational theory and research to clinical applications. Leaders in the field examine basic temperament traits, assessment methods, and what brain imaging and molecular genetics reveal about temperament's biological underpinnings. The book considers the pivotal role of temperament in parent?child interactions, attachment, peer relationships, and the development of adolescent and adult personality and psychopathology. Innovative psychological and educational interventions that take temperament into account are reviewed. Integrative in scope, the volume features extensive cross-referencing among chapters and a forward-looking summary chapter.
Finding Groups In Data
DOWNLOAD
Author : Leonard Kaufman
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-25
Finding Groups In Data written by Leonard Kaufman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-25 with Mathematics categories.
The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. "Cluster analysis is the increasingly important and practical subject of finding groupings in data. The authors set out to write a book for the user who does not necessarily have an extensive background in mathematics. They succeed very well." —Mathematical Reviews "Finding Groups in Data [is] a clear, readable, and interesting presentation of a small number of clustering methods. In addition, the book introduced some interesting innovations of applied value to clustering literature." —Journal of Classification "This is a very good, easy-to-read, and practical book. It has many nice features and is highly recommended for students and practitioners in various fields of study." —Technometrics An introduction to the practical application of cluster analysis, this text presents a selection of methods that together can deal with most applications. These methods are chosen for their robustness, consistency, and general applicability. This book discusses various types of data, including interval-scaled and binary variables as well as similarity data, and explains how these can be transformed prior to clustering.
Pregnancy And Mental Wellness A Holistic Approach For Every Woman
DOWNLOAD
Author : Dr.Samuel Shamaun
language : en
Publisher: Samuel Shamaun
Release Date : 2024-04-19
Pregnancy And Mental Wellness A Holistic Approach For Every Woman written by Dr.Samuel Shamaun and has been published by Samuel Shamaun this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-19 with Antiques & Collectibles categories.
"Pregnancy and Mental Wellness: A Holistic Approach for Every Woman" offers a comprehensive exploration of the intricate relationship between pregnancy and mental well-being. Written with clarity and compassion, this book delves into the myriad emotional, psychological, and physical changes that accompany the journey of pregnancy. Drawing upon both traditional and contemporary perspectives, the authors provide invaluable insights into the holistic needs of expectant mothers. From addressing common concerns such as anxiety and mood swings to navigating the complexities of prenatal depression and stress, this book offers practical guidance and supportive strategies for maintaining optimal mental health throughout pregnancy. With a focus on empowerment and self-care, "Pregnancy and Mental Wellness" emphasizes the importance of holistic approaches, including mindfulness practices, nutrition, and supportive therapies. By integrating mind, body, and spirit, this book advocates for a holistic framework that honors the unique experiences and challenges of every woman during this transformative time. Whether you are an expectant mother, a healthcare professional, or a supportive loved one, "Pregnancy and Mental Wellness" serves as a vital resource for fostering a nurturing and emotionally resilient pregnancy journey. Through its blend of evidence-based insights and compassionate guidance, this book offers a beacon of hope and empowerment for women seeking to prioritize their mental well-being during pregnancy.