Linkage Analysis And Gene Mapping
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Linkage Analysis And Gene Mapping
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Author : Jiankang WANG
language : en
Publisher: EDP Sciences
Release Date : 2023-07-07T00:00:00+02:00
Linkage Analysis And Gene Mapping written by Jiankang WANG and has been published by EDP Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-07T00:00:00+02:00 with Science categories.
One major task of genetic studies is to construct the genetic map through linkage analysis, and then locate the genetic loci of important traits on the constructed linkage maps, identify favorable alleles which are of values to human beings, and investigate their biochemical pathways from genotype to phenotype. This book presents the linkage analysis and gene mapping methodologies, which are applicable to self-pollinated, cross-pollinated, and asexual propagated species, and genetic populations derived from two homozygous parents, two heterozygous parents, and multiple homozygous parents. Chapter 1 in this book begins with genetic mating designs and various types of genetic populations, followed by the structure of commonly used populations and analysis methods of phenotypic data. In chapters 2 and 3, estimation of recombination frequency and construction of linkage map are introduced for twenty bi-parental populations. Chapter 4 deals with two classical gene mapping methods, where no background control is considered, while chapters 5 and 6 describe the inclusive composite interval mapping (ICIM) with background control. Chapter 7 is focused on populations derived from two heterozygous parents, which can be two individuals in a random mating population, two clonal cultivars, or two single crosses from four homozygous inbred lines. Chapter 8 provides knowledge on the pure-line progeny populations derived from four to eight homozygous parents. The last two chapters covers populations, methods and commonly asked questions in genetic mapping which cannot be included previously. This book is intended for readers working on plant and animal genetics, population and quantitative genetics, and plant and animal breeding.
Statistical Genetics
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Author : Benjamin Neale
language : en
Publisher: Garland Science
Release Date : 2007-11-30
Statistical Genetics written by Benjamin Neale and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-30 with Science categories.
Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error. The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.
Analysis Of Human Genetic Linkage
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Author : Jurg Ott
language : en
Publisher: JHU Press
Release Date : 1999-04-16
Analysis Of Human Genetic Linkage written by Jurg Ott and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-16 with Medical categories.
Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.
Gene Mapping Techniques And Applications
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Author : Lawrence B. Schook
language : en
Publisher: CRC Press
Release Date : 2020-07-24
Gene Mapping Techniques And Applications written by Lawrence B. Schook and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-24 with Science categories.
This book explains current strategies for mapping genomes of higher organisms and explores applications of gene mapping to agriculturally important species of plants and animals. It also explores the experimental techniques used for genetic and physical mapping of genes.
Linkage Disequilibrium And Association Mapping
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Author : Andrew R. Collins
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Linkage Disequilibrium And Association Mapping written by Andrew R. Collins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Medical categories.
As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analyses have emerged. In this book, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike. They provide cutting-edge analysis of the most up-to-date and preeminent information available.
Genetic Mapping In Experimental Populations
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Author : J. W. Van Ooijen
language : en
Publisher: Cambridge University Press
Release Date : 2013-08-08
Genetic Mapping In Experimental Populations written by J. W. Van Ooijen and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-08 with Mathematics categories.
A concise introduction to genetic linkage map construction for biological researchers, combining theory with practical exercises and problem-solving tips.
Statistical Genomics
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Author : Ben Hui Liu
language : en
Publisher: CRC Press
Release Date : 2017-11-22
Statistical Genomics written by Ben Hui Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-22 with Mathematics categories.
Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.
Handbook Of Human Genetic Linkage
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Author : Joseph Douglas Terwilliger
language : en
Publisher: JHU Press
Release Date : 1994-04
Handbook Of Human Genetic Linkage written by Joseph Douglas Terwilliger and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-04 with Medical categories.
"A good reference for statisticians and other analysts becoming involved in the popular field of 'gene mapping'." -- "American Journal of Human Genetics"
Genetic Mapping And Dna Sequencing
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Author : Terry Speed
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Genetic Mapping And Dna Sequencing written by Terry Speed and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Mathematics categories.
Genetics mapping, physical mapping and DNA sequencing are the three key components of the human and other genome projects. Statistics, mathematics and computing play important roles in all three, as well as in the uses to which the mapping and sequencing data are put. This volume edited by key researchers Mike Waterman and Terry Speed reviews recent progress in the area, with an emphasis on the theory and application of genetic mapping.
Next Generation Linkage Analysis
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Author : Veronica J. Vieland
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2011
Next Generation Linkage Analysis written by Veronica J. Vieland and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Human genetics categories.
With the advent of affordable high-throughput genetic sequence, the human genetics community is returning to a focus on family data. Sequencing family members can facilitate data cleaning by identifying non-Mendelizing putative variants. It can provide a powerful mechanism for discerning the relevant sequence variants, by focusing on those segregating with the phenotype of interest. By the same token, sequencing holds out the possibility of capitalizing on earlier gene localization findings based on analyses of family data - findings that have provided numerous tantalizing loci for a wide range of complex phenotypes, but to date have resulted in relatively little definitive identifications of specific causal genes. This special issue of 'Human Heredity' is intended to showcase some of the advances in the statistical and computational technologies now available for linkage analysis. As the field returns to an appreciation of the power of linkage analysis, the collection of papers will convey the flavor of what is now possible. Human geneticists and scientists involved in gene mapping studies will gather information on new methods and computer programs available for linkage analysis to parallel sequencing experiments.