Macrocycle Synthesis
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Macrocycle Synthesis
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Author : David Parker
language : en
Publisher:
Release Date : 2023
Macrocycle Synthesis written by David Parker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Macrocyclic compounds categories.
This introduction to synthetic macrocyclic chemistry provides full details of the synthesis of nitrogen-, oxygen- and sulphur-containing macrocycles (such as benzo and chiral crown ethers, cryptands and torands).
Modern Supramolecular Chemistry
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Author : François Diederich
language : en
Publisher: John Wiley & Sons
Release Date : 2008-06-25
Modern Supramolecular Chemistry written by François Diederich and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-25 with Science categories.
Written by internationally acclaimed experts, this handy volume covers all major classes of supramolecular compounds. Chapters include cyclophanes, resorcinarene and calixarene synthesis, supramolecular metallomacrocycles and macrocycle synthesis, rotaxane and catenane synthesis, cucurbiturils and porphyrins, as well as macrocyclic drugs. Each chapter contains experimental procedures allowing fast access to this type of synthetic chemistry.
Practical Medicinal Chemistry With Macrocycles
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Author : Eric Marsault
language : en
Publisher: John Wiley & Sons
Release Date : 2017-09-12
Practical Medicinal Chemistry With Macrocycles written by Eric Marsault and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-12 with Science categories.
Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations
Macrocycles
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Author : Frank Davis
language : en
Publisher: John Wiley & Sons
Release Date : 2011-02-23
Macrocycles written by Frank Davis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-23 with Technology & Engineering categories.
Macrocyclic molecules contain rings made up of seven or more atoms. They are interesting because they provide building blocks for synthesizing precise two or three dimensional structures – an important goal in nanotechnology. For example, they can be used to develop nanosized reaction vessels, cages, switches and shuttles, and have potential as components in molecular computers. They also have applications as catalysts and sensors. Macrocycles: Construction, Chemistry and Nanotechnology Applications is an essential introduction this important class of molecules and describes how to synthesise them, their chemistry, how they can be used as nanotechnology building blocks, and their applications. A wide range of structures synthesised over the past few decades are covered, from the simpler cyclophanes and multi-ring aromatic structures to vases, bowls, cages and more complex multi-ring systems and 3D architectures such as “pumpkins”, interlocking chains and knots. Topics covered include: principles of macrocycle synthesis simple ring compounds multi-ring aromatic structures porphyrins and phthalocanines cyclophanes crown ethers, cryptands and spherands calixarenes, resorcinarenes, cavitands, carcerands, and heterocalixarenes cyclodextrins cucurbiturils cyclotriveratylenes rotaxanes catenanes complex 3D architectures, including trefoils and knots Macrocycles: Construction, Chemistry and Nanotechnology Applications distills the essence of this important topic for undergraduate and postgraduate students, and for researchers in other fields interested in getting a general insight into this increasingly important class of molecules.
Template Synthesis Of Macrocyclic Compounds
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Author : N. V. Gerbeleu
language : en
Publisher: John Wiley & Sons
Release Date : 2008-07-11
Template Synthesis Of Macrocyclic Compounds written by N. V. Gerbeleu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-11 with Science categories.
The synthesis of macrocycles is an art in itself. Template-controlled synthesis provides elegant access to fascinating macrocyclic structures. Polyazamacrocycles, crown ethers, cryptands, rotaxanes, knots -- the range of macrocyclic compounds is as broad as their potential application as molecular switches, in ion exchange, electron transfer or catalysis. This book provides authoritative information on all aspects of template-controlled macrocyclizations. It covers in depth the current state of research on template processes - novel synthetic techniques and mechanistic approaches. The critical discussion of the diverse synthetic routes includes the detailed characterization of the broad variety of macrocyclic products. References to applications of macrocyclic compounds and over 1,500 citations make this handbook an indispensable tool for chemists in academia and industry. Researchers in organic and supramolecular chemistry, biotechnology, and inorganic chemistry will find inspiration for the design, synthesis, and myriad uses of new synthetic macrocycles.
Host Guest Complex Chemistry Macrocycles
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Author : F. Vögtle
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Host Guest Complex Chemistry Macrocycles written by F. Vögtle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The scientific and practical interest in coronands (crown ethers), cryptands, podands as complexing agents for cations as well as for anions and neutral low molecular species is undeniable 1,2). The chemistry of crown compounds is steadily increasing. About 250 original papers dealing with crown chemistry appeared only in 1980. New molecules· with crown ether properties are constantly synthesized and new applications discov,?red. Owing to lack of space, only a small number of the original publications is men tioned here. Thus, in the literature compilation only some, but relevant works are selected for each chapter. Whenever possible, reference is made to reviews or review-like articles alone by means of which origin,al works can be consulted. The reviews given under ref. 1) are considered to be the most relevant. The formulae presented in the figures should be understood as representative structures outlining a specific field. 2 Classification of Oligo-/Multidentate Neutral Ligands and of their Complexes Today, a distinction is made between the classical ring oligoethers (crown ethers) and monocyclic coronands, oligocyclic spherical cryptands and the acyclic podands with respect to topological aspects 3). This classification and the topology are illustrated in Fig. 1, each figure representing the minimum number of donor atoms and chain segments characteristic of each class of compounds. Multidentate mono cyclic ligands with any type of donor atoms are called coronands ("crown compounds"), while the term crown ether should be reserved for cyclic oligoethers exclusively containing oxygen as donor atom.
Peptide Macrocycles
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Author : Matthew B. Coppock
language : en
Publisher: Humana
Release Date : 2022-10-02
Peptide Macrocycles written by Matthew B. Coppock and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-02 with Technology & Engineering categories.
This volume explores the latest techniques and strategies used to study the field of peptide macrocycles. The chapters in this book ae organized into four parts: macrocycles synthesis, combinational library synthesis and screening, macrocycle characterization, and unique applications. Part One looks at a variety of peptide cyclization methodologies, and Part Two describes methods for the creation of peptide macrocycles libraries and their subsequent screening against biological targets of interest. Part Three discusses the study and characterization of peptide macrocycle-target interactions, and Part Four introduces unique applications for peptide macrocycles, from higher-order structure formation to post-synthetic functional modifications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Peptide Macrocycles: Methods and Protocols is a valuable resource for both novice and expert researchers looking to learn more about this developing field.
Macrocycles
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Author : Edwin Weber
language : en
Publisher: Springer
Release Date : 2013-10-03
Macrocycles written by Edwin Weber and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-03 with Science categories.
1. P. Knops, N. Sendhoff, H.-B. Mekelburger, F. Voegtle, Bonn/FRG HighDilution Reactions - New Synthetic Applications 2. A. Ostrowicki, E. Koepp, F. Voegtle, Bonn/FRG The "Cesium Effect": Syntheses of Medio- and Macrocyclic Compounds 3. J. Dohm, F. Voegtle, Bonn/FRG Synthesis of (Strained) Macrocycles by Sulfone Pyrolysis 4. Q. Meng, M. Hesse, Zurich/Switzerland Ring Closure Methods in the Synthesis of Macrocyclic Natural Products 5. J.L. Sessler, A.K. Burrell, Austin, TX/USA Expanded Porphyrins
Macrocycles In Drug Discovery
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Author : Jeremy I Levin
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015
Macrocycles In Drug Discovery written by Jeremy I Levin and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.
This book will review macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. A variety of macrocyclic natural products have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds in the context of their broad chemotype as compounds composed of large rings. The medicinal chemistry of natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, is now informing the design of fully synthetic drug candidates against a variety of targets. Furthermore, as more and more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are becoming increasingly important as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules. An indication of this growing importance is the fact that several companies now provide libraries of macrocyclic molecules produced by proprietary chemical technology to use for lead generation. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.
Synthetic Multidentate Macrocyclic Compounds
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Author : Reed Izatt
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Synthetic Multidentate Macrocyclic Compounds written by Reed Izatt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Synthetic Multidentate Macrocyclic Compounds attempts to bring together selected chapters in which the authors discuss in depth investigations in important areas of macrocycle research. The chapters deal mainly with macrocyclic compounds (saturated polyethers and their derivatives), and macrobicyclic compounds (cryptates). The book contains six chapters and opens with a first-hand account of the initial synthesis of the cyclic polyethers. This is followed by separate chapters on the synthesis of cyclic polyethers, polyether amines, and polyether sulfides; the synthesis of multidentate compounds; and the structure of synthetic macrocyclic compounds and their cation complexes. Subsequent chapters deal with the rates of reactions and the mechanism by which synthetic macrocyclic ligands complex substrates in solution; and commercial applications of the synthetic macrocyclic ligands. This book is primarily aimed at researchers and students in organic, physical, analytical, and inorganic chemistry, and in chemical engineering. However, it will also be of interest to many in the areas of biology, biochemistry, and physiology. Extensive literature references are found in each chapter.