Marine Medicinal Glycomics
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Marine Medicinal Glycomics
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Author : Vitor H. Pomin
language : en
Publisher: Nova Science Publishers
Release Date : 2013
Marine Medicinal Glycomics written by Vitor H. Pomin and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Chitin categories.
Glycomics is an international project that analyses systematically and comparatively the overall and/or specific structural and biological properties of carbohydrates, also known as sugars or glycans, within a repertoire from a given type of cell, tissue, organism, kingdom, or even from a certain environment, as found under specific conditions. Glycomics is one of the latest omics projects to be launched into biology. This was because carbohydrates had been primarily considered as a mere class of structural or energetic molecules. Besides that, structural and functional studies in glycomics are more challenging than other projects, and analytical limitations in glycobiology have impaired the progress. However, with the development of technology, and mostly through recent scientific achievements, innumerous vital biological functions have been uncovered and attributed to the sugars. Moreover, certain glycans may also exhibit effective medicinal properties which have in turn awakened a great interest by pharmaceutical companies.This book compiles and illustrates some of these recent achievements concerning the principle examples of marine sugars with medical properties, such as chitin, chitosan, sulphated polysaccharides, and glycoconjugates. Their therapeutic actions are very broad since they comprise beneficial effects in many systems such as inflammation, coagulation, thrombosis, cancer growth/metastasis, and vascular biology. Additional information about the enzymatic synthesis, chemically modified derivatives, relevance of composing units, and other biochemical properties of these marine medicinal glycans are also discussed herein.
Marine Glycomics
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Author : Yuki Fujii
language : en
Publisher:
Release Date : 2022
Marine Glycomics written by Yuki Fujii and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Marine creatures are rich sources of glycoconjugate-containing glycans and have diversified structures. The advance of genomics has provided a valuable clue for their production and developments. This information will encourage breeding and engineering functional polysaccharides with slime ingredients in algae. These glycans will have the potential for applications to antioxidant, anticancer, and antimicrobial drugs in addition to health supplements and cosmetics. The combination of both biochemical and transcriptome approaches of marine creatures will lead to the opportunity to discover new activities of proteins such as glycan-relating enzymes and lectins. These proteins will also be used for experimental and medical purposes, such as diagnostics and trial studies. The topic of marine glycomics is also focusing on understanding the physiological properties of marine creatures, such as body defense against pathogens and cancers. In the competitions for natural selection, living creatures have evolved both their glycans and their recognition. They have primitive systems of immunity, and few of their mechanisms are closely related to glycans. If we are able to describe the accumulation of data of glycans of creatures living in the seashore and the oceans, we may be able to anticipate a time when we can talk about the ecosystem with glycans. That knowledge will be useful for the development of drugs that cure our diseases and for an understanding of living systems in addition to the preservation of living environments.
Marine Carbohydrate Based Compounds With Medicinal Properties
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Author : Irina M Yermak
language : en
Publisher:
Release Date : 2021-11
Marine Carbohydrate Based Compounds With Medicinal Properties written by Irina M Yermak and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11 with categories.
The marine environment is considered one of the most important sources of natural bioactive compounds with extremely rich biodiversity. Marine glycans are remarkable molecules, playing a determinant role in biological processes. Marine сarbohydrate-containing substances have drawn increasing attention in the field of biomedicine for their various biological activities, such as antitumor, antivirus, hypoglycemic, immunomodulatory, and anticoagulant. These compounds obtained from marine sources, such as algae, microbes, and animals, are usually biodegradable and biocompatible, and exhibit biological properties that contribute to the discovery of a wide range of new bioactive substances with special pharmacological properties of interest to medicine. Carbohydrate-based compounds include glycans, glycoproteins, proteoglycans, glycolipids, and low-molecular and complex glycosides of differential origin. Many of the polysaccharides allow for loading lower drug dosages, which may lead to a drastic reduction of the side effects caused by the drugs. In addition, the structure of polysaccharides can be relatively easily modified in order to synthesize derivatives with desirable characteristics for drug delivery. Complexes on the basis of carbohydrates are often prepared to improve their functional properties. In this Special Issue, we seek to contribute to the discussion of various aspects of marine carbohydrate-containing compounds and provide a unique platform for a new concept for their use in medicine in order to continue to facilitate further research in this area.
Glycan Diversity In Fungi Bacteria And Sea Organisms
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Author : Eliana Barreto-Bergter
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-07
Glycan Diversity In Fungi Bacteria And Sea Organisms written by Eliana Barreto-Bergter and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-07 with Infectious and parasitic diseases categories.
The cell surface of fungi, bacteria and sea organisms is highly glycosylated. These glycans are oligo- or polysaccharide molecules that can be secreted or attached to protein or lipids forming glycoconjugates. They present extraordinary structural diversity that could explain their involvement in many fundamental cellular processes, including growth, differentiation and morphogenesis. Considerable advances have been made on the structural elucidation of these glycans. Their primary structures were determined based on a combination of mass spectrometry and NMR spectroscopy techniques. The combination of these sensitive and powerful techniques has allowed us to increase our structural knowledge of a wide variety of glycans expressed by different fungi, bacteria and sea organisms.
Marine Glycosides
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Author : Thomas E Adrian
language : en
Publisher: MDPI
Release Date : 2019-05-03
Marine Glycosides written by Thomas E Adrian and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-03 with Medical categories.
In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.
Marine Glycobiology
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Author : Se-Kwon Kim
language : en
Publisher: CRC Press
Release Date : 2016-10-14
Marine Glycobiology written by Se-Kwon Kim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-14 with Medical categories.
Marine glycobiology is an emerging and exciting area in the field of science and medicine. Glycobiology, the study of the structure and function of carbohydrates and carbohydrate-containing molecules, is fundamental to all biological systems and represents a developing field of science that has made huge advances in the last half-century. This book revolutionizes the concept of marine glycobiology, focusing on the latest principles and applications of marine glycobiology and their relationships.
Synthetic Glycomes
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Author : Wanyi Guan
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-04-23
Synthetic Glycomes written by Wanyi Guan and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-23 with Science categories.
Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in understanding the functions of glycans. However, limited accessibility of glycans is a major obstacle to the functional glycomics study. Although isolation from biology samples provided some structures, the low abundance of glycans obtained and the difficulty in complete structural assignment restricted the subsequent assay. To circumvent this limitation, many synthetic strategies, including chemical, enzymatic and chemo-enzymatic ones have been developed to make libraries of structurally defined complex glycans available. The glycans provided by these techniques combined with high-throughput glycoarray techniques have broadened and deepened our understanding about functional glycomics. The aim of this book is to provide a comprehensive review of the current state of the synthetic glycome and a brief introduction of the application of the synthetic glycome in glycoarray assay. Accordingly, synthetic strategies toward generating glycans with comprehensive structures as well as the glycoarrays to unveil the glycan functions are described in this book.
Marine Biochemistry
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Author : Se-Kwon Kim
language : en
Publisher: CRC Press
Release Date : 2022-10-12
Marine Biochemistry written by Se-Kwon Kim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-12 with Medical categories.
This book provides the latest comprehensive methods for isolation and other novel techniques for marine product development. Furthermore, this book offers knowledge on the biological, medical, and industrial applications of marine-derived medicinal food substances. There has been a tremendous increase in the products derived from marine organisms for commercial application in industries every year. Functional foods of medicinal value are particularly in demand as new technology allows the stabilization of natural ingredients and their availability in pure forms to solve various human diseases. Marine flora and fauna have essential elements and trace minerals that nurture various hormones produced in the endocrine system to regulate the respective metabolisms, thereby providing a safe and healthy life to humans. The overall presentation and clear demarcation of the contents by worldwide contributions is a novel entry point into the market of medicinal foods from the sea. The exploration of marine habitats for novel materials are discussed throughout the book. The exploration and exploitation of the biochemistry of sea flora and fauna are limited, and this book extends the research possibilities into numerous marine habitats. Various approaches for extracting and applying the flora and fauna are discussed. This book will be of value to researchers, marine biotechnologists, and medical practitioners, due to the vast information, as well as industrial and medical applications of marine substances all in one place.
Marine Glycobiology Glycomics And Lectins
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Author : Yasuhiro Ozeki
language : en
Publisher: MDPI
Release Date : 2019-11-20
Marine Glycobiology Glycomics And Lectins written by Yasuhiro Ozeki and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-20 with Medical categories.
Glycans (carbohydrate chains) of marine creatures are rich and diverse in polysaccharides, glycoproteins, and glycolipids. The chains that are metabolized by glycan-related enzymes (glycosyltransferases and glycosidases) are recognized by glycan-binding proteins (lectins) which regulate cellular processes such as growth, differentiation, and death. Marine glycomics that involves the genome and transcriptome accelerates our understanding of the evolution of glycans, glycan-related enzymes, and lectins. From 2017 to 2019, the Special Issue “Marine Glycobiology, Glycomics and Lectins” of the journal Marine Drugs published scientific articles and reviews, on the background of “glycobiology”—that is, glycan-based biosciences. The aim was to promote the discovery of novel biomolecules that contribute to drug development and clinical studies. This has great potential for establishing connections between the fields of both human health and marine life sciences. This book contains 11 scientific papers representing current topics in comprehensive glycosciences related to therapeutic agents from marine natural products, as outlined.
Advances In Marine Chitin And Chitosan
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Author : David Harding
language : en
Publisher: MDPI
Release Date : 2018-10-02
Advances In Marine Chitin And Chitosan written by David Harding and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-02 with Chitin categories.
This book is a printed edition of the Special Issue "Advances in Marine Chitin and Chitosan" that was published in Marine Drugs