Mechanical Adaptation Of Trabecular Bone Formation In Vivo

DOWNLOAD

Download Mechanical Adaptation Of Trabecular Bone Formation In Vivo PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Mechanical Adaptation Of Trabecular Bone Formation In Vivo book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Mechanical Adaptation Of Trabecular Bone Formation In Vivo

DOWNLOAD
Author : Robert Erling Guldberg
language : en
Publisher:
Release Date : 1995

Mechanical Adaptation Of Trabecular Bone Formation In Vivo written by Robert Erling Guldberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.

Multiscale Mechanobiology Of Bone Remodeling And Adaptation

DOWNLOAD
Author : Peter Pivonka
language : en
Publisher: Springer
Release Date : 2017-06-20

Multiscale Mechanobiology Of Bone Remodeling And Adaptation written by Peter Pivonka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-20 with Science categories.

The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Bone Research In Biomechanics

DOWNLOAD
Author : G. Lowet
language : en
Publisher: IOS Press
Release Date : 1997

Bone Research In Biomechanics written by G. Lowet and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Biomechanics categories.

This book focuses on the structure of bone, and its consequences for the mechanical behaviour of the bone structure. The first part of this book focuses on the development of models to predict the adaptation of bone due to changes on the mechanical loading situation (such as provoked by an implant). But far more important than the computer power presently available, the incorporation of knowledge on the biological processes have led to new kinds of models. Next to the development of models itself, the issue of model validation though comparison with clinical data is a main issue addressed in the papers of this symposium. The second part, dealing with the relationship between bone architecture and competence of bone, focuses on the morphology of trabecular bone structure. This work is mainly carried out in the context of research on osteoporosis, and look for the relation between bone structure and fracture risk. The last part is devoted to ultrasound research in bone biomechanics. Several methods have been described for the in vitro and in vivo measurement of ultrasound velocity and attenuation, both on cortical and on trabecular bone. The reader will not only discover the state-of-the-art when reading though this book. This book can give a taste of the fascinating perspectives the research in bone biomechanics still have to offer, even after more than 100 years.

Mechanical Loading Induced Adaptation Of The Mouse Tibia

DOWNLOAD
Author : James Christopher Fritton
language : en
Publisher:
Release Date : 2006

Mechanical Loading Induced Adaptation Of The Mouse Tibia written by James Christopher Fritton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

Cancellous Bone Adaptation To Non Invasive Mechanical Loading In The Murine Tibia

DOWNLOAD
Author : Maureen Ellen Lynch
language : en
Publisher:
Release Date : 2010

Cancellous Bone Adaptation To Non Invasive Mechanical Loading In The Murine Tibia written by Maureen Ellen Lynch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Osteoporosis causes over 2 million skeletal fractures every year in people 50 years of age or older. Fractures predominantly happen at corticocancellous sites, such as the hip and spine. Due to lower accrual of bone mass during growth and rapid bone loss following menopause, 71% of these fractures occur in women. Mechanical loading, which stimulates bone formation, is a potential anabolic therapy for pathological bone loss. Determining the parameters of mechanical loading that stimulate osteogenesis in cancellous bone is critical for harnessing the therapeutic potential of mechanical stimuli. In this thesis, the effects of sex, aging, and estrogen deficiency on the adaptive response of cancellous bone were examined using in vivo tibial compression applied to mice. The effect of sex on the cancellous adaptive response to tibial loading was investigated in growing mice. The magnitude of peak applied loads that corresponded to +1200 [mu][epsilon]at the tibial mid-shaft was determined to be -11.5 N in both males and females from in vivo strain gauging. This peak load resulted in similar peak cancellous tissue strains of ~-2400 [mu][epsilon]in females and ~-2100 [mu][epsilon]. Following 2 weeks of tibial compression, male and female mice increased cancellous bone mass 73% in the proximal tibia, primarily through increased trabecular thickening (+75%). Tissue mineral density increased 18% and trabecular separation decreased 19% as well. As a result of adaptation, the proportion of the applied load carried by the cancellous compartment, rather than by the cortical shell, increased. In addition, the metaphyseal stiffness of the loaded limbs was greater than in control limbs. None of these loadinginduced changes differed by sex. Next, the effect of aging on the cancellous adaptive response was investigated in adult, osteopenic female mice, and this response was compared to that observed previously in growing mice. We applied the same peak compressive loads (-11.3 N) to one group of adult female mice (Load-Matched), which corresponded to +2200 [mu][epsilon]mid-diaphyseal strains and peak cancellous tissue strains of -2257 [mu][epsilon]. We applied the same peak mid-diaphyseal strains (+1200 [mu][epsilon]) to a second group of adult female mice (Strain-Matched), engendered by -5.9 N peak applied load, which corresponded to peak cancellous tissue strains of -1112 [mu][epsilon]. In the LM group, cancellous bone mass increased 49% through increased trabecular thickening (+64%), and cortical mass increased 41% through medullary contraction (-19%). These adaptive changes increased the metaphyseal stiffness of loaded limbs relative to control limbs (IMAX +88%, IMIN +54%). No adaptive response was observed in the SM group. The response in the cancellous compartment was reduced relative to that observed in growing mice. However, tibial loading recovered age-related loss to levels equivalent to control limbs of young animals, supporting the use of mechanical loading as a therapeutic intervention against osteoporotic fractures. In contrast, the response in the cortical compartment was enhanced relative to that in young mice. While both young and adult mice similarly increased IMAX and cortical area, adult mice underwent enhanced medullary contraction. Finally, tibial compression was applied to osteopenic, estrogen-deficient adult female mice to demonstrate that mechanical loading can stimulate cancellous bone formation following estrogen withdrawal. Loading was applied immediately following ovariectomy (OVX) or sham (Sham) surgery and lasted 1, 2, and 6 weeks to characterize the adaptive response over time. Estrogen deficiency did not inhibit the adaptive response of cancellous bone in adult females. After 6 weeks of loading, cancellous bone mass increased similarly in Sham and OVX groups. Cancellous bone mass exhibited a bimodal change with loading due to the different effects of loading and estrogen deficiency, acting at different rates, on cancellous architecture. Loading primarily increased trabecular thickness while estrogen deficiency primarily increased separation. No differences in the control limbs between Sham and OVX groups were observed within the 6 week time period. In summary, tibial compression elicited a robust anabolic response in cancellous bone, which increased mass in growing young male and female mice, and in osteopenic and estrogen deficient adult female mice. Cancellous mass occurred primarily through trabecular thickening and resulted in an overall stiffer tibia metaphysis. Tibial compression recovered age-related bone loss in osteopenic adult female mice to levels equivalent to the control limbs of young mice, even following estrogen withdrawal. These results demonstrate that mechanical loading can be targeted to corticocancellous sites to increase bone mass, improve structural integrity, and reduce risk for fracture. Additionally, these results demonstrate that mechanical loading can be implemented as a preventative measure, either in growing children, or pre- and peri-menopausal women, to increase peak bone mass and reduce risk of fracture.

Mechanical Loading Of Bones And Joints

DOWNLOAD
Author : Hideaki E. Takahashi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Mechanical Loading Of Bones And Joints written by Hideaki E. Takahashi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Bones and joints are always under mechanical loading a key concept in understanding bone metabolism. Among the most common diseases of bones and joints in the elderly are osteoporosis and joint osteoarthritis. Dynamic changes in mechanical loading give rise to problems resulting in stenosis of the spinal column at the cervical, thoracic, and lumbar levels. Mechanical loading also accelerates joint destruction caused by inflammation from such conditions as chronic rheumatoid arthritis. An understanding of mechanical loading is essential therefore to clinicians, basic researchers, and engineers working with bones and joints. Providing up-to-date research and clinical findings, the contents of this volume are from the papers, symposia, and special lectures presented at the 12th Annual Meeting of the Orthopaedic Research Meeting of the Japanese Orthopaedic Association in Niigata, in October 1997.

The Process Of Mechanical Adaptation In Trabecular Bone

DOWNLOAD
Author : Margriet Gezina Mullender
language : en
Publisher:
Release Date : 1997

The Process Of Mechanical Adaptation In Trabecular Bone written by Margriet Gezina Mullender and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Orthopedics categories.

Zsfassung in niederländ. Sprache.

Mechanical Behavior And Adaptation Of Trabecular Bone In Relation To Bone Morphology

DOWNLOAD
Author : Bert van Rietbergen
language : en
Publisher:
Release Date : 1996

Mechanical Behavior And Adaptation Of Trabecular Bone In Relation To Bone Morphology written by Bert van Rietbergen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

Zsfassung in niederländ. Sprache.

The Law Of Bone Remodelling

DOWNLOAD
Author : Julius Wolff
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

The Law Of Bone Remodelling written by Julius Wolff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Translated from the German by Maquet, P.; Furlong, R.

Marcus And Feldman S Osteoporosis

DOWNLOAD
Author : David W. Dempster
language : en
Publisher: Academic Press
Release Date : 2020-10-08

Marcus And Feldman S Osteoporosis written by David W. Dempster and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Science categories.

Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders