Mechanisms Of Lymphocyte Exclusion In The Tumor Microenvironment
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Mechanisms Of Lymphocyte Exclusion In The Tumor Microenvironment
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Author : Sarah E. Church
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-24
Mechanisms Of Lymphocyte Exclusion In The Tumor Microenvironment written by Sarah E. Church and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-24 with Medical categories.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Encyclopedia Of Immunobiology
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-04-27
Encyclopedia Of Immunobiology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-27 with Medical categories.
Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices
The Biomarkers Mechanism And Therapeutic Strategies Of Cancer Immunotherapy Resistance
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Author : Mou Peng
language : en
Publisher: Frontiers Media SA
Release Date : 2025-07-30
The Biomarkers Mechanism And Therapeutic Strategies Of Cancer Immunotherapy Resistance written by Mou Peng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-30 with Science categories.
Over the decades, cancer immunotherapy has been a burgeoning science in medicine and an established pillar of therapeutic options for diverse cancer types. Leading the way to success is mainly the discovery and development of immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T cell-based therapies. Under immunotherapy, a portion of cancer patients enables to achieve a significant and durable remission with a longer survival time, particularly in those with lung cancer, melanoma, genitourinary cancer, etc. However, striking disparities still exist in the effectiveness of anticancer immunotherapy and cause a great challenge to select appropriate candidates. A large part of cancer patients presents limited or no response to immunotherapy, mainly attributable to immunotherapy resistance. Despite of great strides already made, the exact mechanism underlying immunotherapy resistance is still enigmatic. Immunotherapy resistance is extremely complex and involves voluminous aspects such as tumor-intrinsic factors (aberrant expression of tumor antigens, alterations of signaling pathways, etc.), tumor-extrinsic factors (local tumor microenvironment, etc.) and host-related factors (gender, age, etc.). More efforts should be made to characterize the underlying mechanism and uncover robust targets for a better response rate.
Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches
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Author : Rifat Hamoudi
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-02
Understanding The Immuno Oncological Mechanism Of Cancer Using Systems Immunology Approaches written by Rifat Hamoudi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-02 with Medical categories.
The Role Of The Tumor Microenvironment Tme And Relevant Novel Biomarkers In Oncogenesis 2nd Edition
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Author : Zhouxiao Li
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-25
The Role Of The Tumor Microenvironment Tme And Relevant Novel Biomarkers In Oncogenesis 2nd Edition written by Zhouxiao Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with Science categories.
Tumors and their surroundings are closely related and constantly interact. Tumors can influence their microenvironment by releasing cell signaling molecules that promote neoplasm angiogenesis and induce immune tolerance, while immune cells in the microenvironment can influence cancer cell growth and development. The tumor microenvironment (TME), a complex biological ecosystem for cancer cells to survive and develop refers to the surrounding circumstances of cancer cells, including surrounding blood vessels, immune cells, fibroblasts, bone marrow inflammatory cells, various signaling molecules and extracellular matrix (ECM). The immune cells and their regulation mode in TME have tumor-antagonizing or tumor-promoting functions. TME has been gradually recognized as a key contributor to cancer progression and drug resistance, with cellular components in the TME able to enhance tumor resistance by recruiting and secreting multiple protective cytokines. The acellular components of TME can mediate drug resistance by building physical barriers, affecting tumor cell growth and metabolism, etc. Knowledge of the above is paving the way for identifying new targets and discovering new therapies. Studying the dynamic relationship between tumor surroundings and neoplasm, and clarifying the molecular mechanism of different factors refers to TME in the process of tumor progression, are the key elements of cancer inhibition. Currently, there is a proliferation of publicly available tumor genomic databases. Such as the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Surveillance, Epidemiology, and EndResults Program (SEER), International Cancer Genome Consortium (ICGC) and National Cancer Database (NCDB). These abundant public database resources enable researchers to mine multi-omics cancer data to better understand the interactions between tumors and their microenvironment and to discover biomarkers and therapeutic targets in TME that are associated with tumorigenesis. This provides new targets for early diagnosis and precise treatment of tumors. In this research topic, we would like to demonstrate the function and mechanism of tumor microenvironment in tumorigenesis and development through various methods, including sequencing, bioassay, experimental models such as PDX and organoids. We welcome original research articles and reviews dedicated to: 1) Mechanisms of tumor microenvironment involvement in tumor progression. 2) Bioinformatics or big data demonstrating the role of the tumor microenvironment in tumor progression 3) Molecular therapeutic mechanisms and clinical studies related to the tumor microenvironment 4) Biomarkers and therapeutic targets related to tumor microenvironment 5) Drug resistance mechanism related to tumor microenvironment
Beyond Pd 1 Novel Checkpoint Receptors And Ligands As Targets For Immunotherapy
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Author : Jesse Haramati
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-24
Beyond Pd 1 Novel Checkpoint Receptors And Ligands As Targets For Immunotherapy written by Jesse Haramati and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-24 with Medical categories.
The incredible power of the immune system to control or eliminate neoplasias has been made evident by the success of immune checkpoint inhibitors (ICI). While inhibitory checkpoint receptors are critical for the maintenance of hemostasis under physiological conditions, dysregulation in the tumor microenvironment perturbs the role of these molecules with the promotion of exhausted cytotoxic cells, that is cytotoxic cells that no longer are able to control tumors. ICI leverages these targets to redirect cytotoxic responses and neutralize the suppressive tumor microenvironment. However, not all tumor types or patients respond to these therapies. Great interest continues to be focussed on first-generation ICI therapy (PD-1/PD-L1 and CTLA-4) but the potential for other targets and ligands remains vast.
Regulatory Mechanisms Of Early Intracellular Signaling In T Lymphocytes
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Author : Enrique Aguado
language : en
Publisher: Frontiers Media SA
Release Date : 2021-05-21
Regulatory Mechanisms Of Early Intracellular Signaling In T Lymphocytes written by Enrique Aguado and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-21 with Science categories.
Histopathology
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Author : Supriya Srivastava
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-09-19
Histopathology written by Supriya Srivastava and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-19 with Medical categories.
This book, "Histopathology-An Update" is a comprehensive book that deals with the latest advances in the field of histopathology. This book will be of help to pathologists, clinicians and researchers in the latest update in histopathology of various organs.
Ion Channel Signalling In Cancer From Molecular Mechanisms To Therapeutics
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Author : Elena Adinolfi
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-02
Ion Channel Signalling In Cancer From Molecular Mechanisms To Therapeutics written by Elena Adinolfi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-02 with Science categories.