Mechanisms Of Molecular Carcinogenesis Volume 2
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Mechanisms Of Molecular Carcinogenesis Volume 2
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Author : Johannes Haybaeck
language : en
Publisher: Springer
Release Date : 2017-05-22
Mechanisms Of Molecular Carcinogenesis Volume 2 written by Johannes Haybaeck and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Medical categories.
Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects. This second volume complements the first by presenting and concisely explaining the carcinogenesis of various tumor entities such as non-melanoma skin cancers, bone and soft tissue tumors, pancreatic cancers, hepatocellular cancer and neuroendocrine tumors. As in volume one, each chapter illuminates the similarities and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic strategies. The focus of volume two lies on the presentation of modern molecular biological techniques for diagnosis, as well as strategies for biomarker identification and validation. Furthermore, it discusses potential therapeutic targets and individualized treatment strategies, offering a valuable resource for all basic scientists and medical researchers interested in translational cancer research.
Mechanisms Of Molecular Carcinogenesis Volume 1
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Author : Johannes Haybaeck
language : en
Publisher: Springer
Release Date : 2017-05-23
Mechanisms Of Molecular Carcinogenesis Volume 1 written by Johannes Haybaeck and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-23 with Medical categories.
Divided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects. This 1st Volume presents tumor entities of the ocular system, the thyroid organ, the oesophagus, gliomas, non-glial brain tumors, head and neck as well as lung cancer. In addition it also discusses in-depth potential novel molecular players and the role of stem cells as well as the endocannabinoid system in carcinogenesis, it furthermore explains tumor metabolism components and signaling pathways. Each of the chapters discusses potential therapeutic strategies and novel drug targets. The book addresses basic scientists and medical researchers interested in translational cancer research.
Mechanisms Of Carcinogenesis
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Author : Patricia A. Buffler
language : en
Publisher: IARC Scientific Publications
Release Date : 2004
Mechanisms Of Carcinogenesis written by Patricia A. Buffler and has been published by IARC Scientific Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
During the last two decades, molecular epidemiology has become an important discipline in cancer research. It has evolved towards the development, validation and application of markers of susceptibility and, more recently, markers of mechanisms of cancer development. This volume on mechanisms of carcinogenesis covers from an interdisciplinary perspective, the contribution of molecular epidemiology to the understanding of mechanisms of carcinogenesis, and represents a further contribution to the development of molecular epidemiology as a major cancer research domain.
Diet And Cancer
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Author : Maryce M. Jacobs
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Diet And Cancer written by Maryce M. Jacobs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
The fifth of the annual research conferences of the American Institute for Cancer Research was held September l-2, 1994, at the L'Enfant Plaza Hotel in Washington, DC. Appropriately, in view of current directions in research, the theme was "Diet and Cancer: Molecular Mechanisms of Interactions". This proceedings volume contains chapters from the platform presentations and abstracts from the poster session held on the end of the first day. The subtopics for the tl;rree sessions held were "Retinoids, Vitamins A and Din Cancer Prevention and Therapy," "Choline and Lipids: Signal Transduction, Gene Expression and Growth Regulation," and "Dietary Factors and Regulation of Oncogenes, Growth and Differentiation. " A general overview on vitamins A and D emphasized that A and D, in addition to their established roles in vision, reproduction, and bone mineral homeostasis, may play significant roles in regulating cell function. Vitamin A metabolites, trans-retinoic acid and 9-cis-retinoic acid, regulate growth and differentiation. Furthermore, vitamin A deprived animals were more susceptible to both spontaneous and carcinogen-induced tumors. Epidemiological studies showed a correlation between low A intake and higher incidences of certain types of human cancers. Conversely, all-trans retinoic acid is useful in treatment and control of certain types of cancer. Physiologically, Vitamin D is converted to the active form, l ,25-dihydroxyvitamin D (VD). VD regulates hormone production and secretion, myocardial contractility, vascu 3 3 3 lar tone, and growth inhibition and differentiation.
Mechanisms Of Carcinogenesis In Risk Identification
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Author : Harri Vainio
language : en
Publisher:
Release Date : 1992
Mechanisms Of Carcinogenesis In Risk Identification written by Harri Vainio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
This comprehensive, authoritative volume includes a consensus document drawn up by a working group of international experts in various fields of carcinogenesis. It describes the multistage and multifactorial nature of carcinogenesis, the different mechanisms of action of carcinogens, epidemiological and laboratory means for their identification, and proposed principles and procedures for their possible use in the prediction and evaluation of carcinogenic risks to humans. Other chapters cover critical molecular targets in chemical carcinogenesis; mechanisms of carcinogenicity; animal carcinogenicity tests and their interpretations; biological markers in exposed humans; and data analysis and modelling. This work will be a valuable reference for cancer researchers and toxicologists.
Mechanisms Of Carcinogenesis
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Author : Elizabeth K. Weisburger
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mechanisms Of Carcinogenesis written by Elizabeth K. Weisburger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
Molecular Mechanisms Of Cancer
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Author : Georg F. Weber
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-12
Molecular Mechanisms Of Cancer written by Georg F. Weber and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-12 with Medical categories.
This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
Molecular Therapies Of Cancer
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Author : Georg F. Weber
language : en
Publisher: Springer
Release Date : 2015-07-22
Molecular Therapies Of Cancer written by Georg F. Weber and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-22 with Medical categories.
Molecular Therapies of Cancer comprehensively covers the molecular mechanisms of anti-cancer drug actions in a comparably systematic fashion. While there is currently available a great deal of literature on anti-cancer drugs, books on the subject are often concoctions of invited review articles superficially connected to one another. There is a lack of comprehensive and systematic text on the topic of molecular therapies in cancer. A further deficit in the relevant literature is a progressive sub-specialization that typically limits textbooks on cancer drugs to cover either pharmacology or medicinal chemistry or signal transduction, rather than explaining molecular drug actions across all those areas; Molecular Therapies of Cancer fills this void. The book is divided into five sections: 1. Molecular Targeting of Cancer Cells; 2. Emerging and Alternative Treatment Modalities; 3. Molecular Targeting of Tumor-Host Interactions; 4. Anti-Cancer Drug Pharmacokinetics; and 5. Supportive Therapies.
Molecular Biology Of Cancer
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Author : Lauren Pecorino
language : en
Publisher: Oxford University Press, USA
Release Date : 2012-04-26
Molecular Biology Of Cancer written by Lauren Pecorino and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-26 with Medical categories.
Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.
Small Molecules In Oncology
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Author : Uwe M. Martens
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-14
Small Molecules In Oncology written by Uwe M. Martens and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-14 with Medical categories.
Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.