Membrane Sorting In The Endocytic Pathway

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Membrane Sorting In The Endocytic Pathway

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Author : Valentina Mercanti
language : en
Publisher:
Release Date : 2007

Membrane Sorting In The Endocytic Pathway written by Valentina Mercanti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

During my thesis work I studied membrane sorting in the endocytic pathway, in mammalian cells and in the amoeba "Dictyostelium discoideum". In the first part (1), I studied sorting of membrane proteins devoid of known endocytosis signals. My results show that, in addition to cytoplasmic tails of membrane proteins, then transmembrane regions determine whether they are excluded or not from clathrincoated pits, and thus controls their access to endosomal compartmemts. In the second part (2), I studied membrane sorting during phagocytosis and macropinocytosis. I used for this the amoeba "Dictyostelium discoideum". My results show that several plasma membrane proteins are excluded from the membrane of the newly formed phagosome. This exclusion starts in the membrane delimiting the phagocytic and the macropinocytic cups. Analysis of mutant strains revealed that clathrin-associated adaptor complexes were not necessary for this selective exclusion. In third part (3), I characterized the previously uncharacterized recycling endosomes in "Dictyostelium discoideum"

Signal Dependent Membrane Protein Sorting In The Endocytic Pathway

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Author : Charles Gregory Odorizzi
language : en
Publisher:
Release Date : 1996

Signal Dependent Membrane Protein Sorting In The Endocytic Pathway written by Charles Gregory Odorizzi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

Receptor Ligand Sorting Along The Endocytic Pathway

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Author : Jennifer J. Linderman
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08

Receptor Ligand Sorting Along The Endocytic Pathway written by Jennifer J. Linderman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Mathematics categories.

This research monograph focuses on a biomolecular separation process that occurs within most cells. Two types of molecules, receptors and ligands, are separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable parameters that influence the event. Mathematical models of sorting are evaluated to predict the range of possible outcomes. These are compared with a variety of experimental data on different receptor/ligand systems. In addition, the influence of the separation on overall receptor/ligand processing dynamics is discussed. The book is intended for both biomathematicians and biologists. It is not necessary to understand the details of the model equations and their solution in order to test the models experimentally. The analysis suggests experiments that might be done to further investigate the sorting process and the text details methods for analyzing these experimental results.

Molecular Biology Of The Cell

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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002

Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.

Membrane Trafficking Pathways And Protein Sorting In The Yeast Saccharomyces Cerevisiae

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Author : Edina Harsay
language : en
Publisher:
Release Date : 1996

Membrane Trafficking Pathways And Protein Sorting In The Yeast Saccharomyces Cerevisiae written by Edina Harsay and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

Endocytosis And Signaling

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Author : Christophe Lamaze
language : en
Publisher: Springer
Release Date : 2018-08-10

Endocytosis And Signaling written by Christophe Lamaze and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-10 with Science categories.

This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.

Specialized Endocytic Sorting Of The Beta 2 Adrenergic Receptor

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Author : Tracy T. Cao
language : en
Publisher:
Release Date : 1999

Specialized Endocytic Sorting Of The Beta 2 Adrenergic Receptor written by Tracy T. Cao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Adrenaline categories.

Endosomes

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Author : Ivan Dikic
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-07

Endosomes written by Ivan Dikic and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-07 with Science categories.

Endosomes are a heterogeneous population of endocytic vesicles and tubules that have captivated the interest of biologists for many years, partly due to their important cellular functions and partly due to their intriguing nature and dynamics. Endosomes represent a fascinating interconnected network of thousands of vesicles that transport various cargoes, mainly proteins and lipids, to distant cellular destinations. How endosomes function, what co-ordinates the molecular determinants at each step of their dynamic life cycle and what their biological and medical relevance is, are among the questions addressed in this book.

Trafficking Inside Cells

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Author : Nava Segev
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-30

Trafficking Inside Cells written by Nava Segev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-30 with Science categories.

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Trafficking Of Intracellular Membranes

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Author : Maria C. Pedroso De Lima
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Trafficking Of Intracellular Membranes written by Maria C. Pedroso De Lima and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.

This volume contains the lectures presented at the NATO Advanced Study Institute (ASI) on "Trafficking of Intracellular Membranes: From Molecular Sorting to Membrane Fusion", held in Espinho, Portugal, from June 19 to June 30,1994. The objective of this Institute was to survey recent developments and to discuss future directions in the rapidly advancing field of membrane cell biology, with particular emphasis on the dynamical properties and intracellular flow of membranes. A wide range of interrelated topics around the central theme of intracellular trafficking of membranes was covered, including lipid flow, membrane fusion, dynamics of membrane components, protein folding and assembly, vesicular transport in membrane biogenesis, exocytosis and endocytosis. A large variety of experimental techniques and systems, including the application of viruses and model systems, to study these processes was also considered. Membrane cell biology is a broad discipline which encompasses many scientific areas including cell biology, biochemistry, biophysics, virology, immunonology and genetics. Indeed, recent advances in the cell biology of membranes could not have been made without this multidisciplinary approach. Significant progress achieved during the last few years in understanding how newly synthesized lipids and proteins find their way to the cell organelles, how molecular sorting and the continuous flow of membranes allow each cellular membrane to maintain its own distinct molecular composition, and, thereby, the individuality of the various intracellular compartments, was discussed in considerable detail in this Institute.