Metabolomics And Its Impact On Health And Diseases
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Metabolomics And Its Impact On Health And Diseases
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Author : Veronica Ghini
language : en
Publisher: Springer Nature
Release Date : 2023-03-03
Metabolomics And Its Impact On Health And Diseases written by Veronica Ghini and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-03 with Medical categories.
This volume of the Handbook of Experimental Pharmacology, which celebrated its 100th anniversary in 2019, addresses the rapidly growing and evolving field of metabolomics. It has been compiled and designed to broaden and enrich your understanding as well as simplify a complicated picture of the diverse field of metabolomics. This is accomplished by chapters from experts in the field on basic principles as well as reviews and updates of analytical techniques. The variety and different perspectives of the NMR approaches are described in the chapters By David Wishart, Daniel Raftery and Ryan McKay, while mass spectrometry advances are covered by Charles R. Evans and Stefan Kempa. This book also reflects the state of the art in the application of metabolomics to cell biology (Marta Cascante and Ulrich Guenther) and chapters that share insights into the application of metabolomics in various diseases (Paola Turano and Claudio Luchinat, Rachel S. Kelly and Jessica Lasky-Su, Paige Lacy, and Angela Rogers. Relationships of metabolomics with drugs are highlighted by Robert Verpoorte (natural products drug discovery), by Oscar Millet and by Turano and Luchinat (perspectives in precision medicine) and by Daniel L. Hertz (drug-induced peripheral neuropathy). From the above list of diverse topics, we believe this book has interdisciplinary appeal and scholars with an interest in the role of metabolomics in achieving precision medicine will find it of particular or special interest.
Metabolomics In Health And Disease Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-02-26
Metabolomics In Health And Disease Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-26 with Science categories.
Metabolomics in Health and Disease Biology, Volume 104 covers this rapidly emerging field that aims for metabolic phenotyping and understanding the blueprint of metabolic pathways under various health and disease conditions by comprehensive analysis of metabolites. Chapters in this new release include Metabolomics approaches: Biomarkers to Disease mechanisms, Metabolomics in sleep disorders, Metabolomics in predicting the hallmark of Cancer Metabolism, Spectroscopic based rapid metabolic fingerprinting approaches for Cancer diagnosis, Lipidomics in assessing the health of osteoarthritis, Metabolomics Applications in Type 2 Diabetes mellitus, Metabolomics of Diabetic retinopathy, Metabolomics in Neurodegenerative disorders- Parkinson's disease, and Metabolomic of Neurodegenerative disorder: Alzheimer's Disease. Presents crucial reviews from selected experts in the field of metabolomics, with cross-disciplinary contributions Provides the latest insights into our understanding of diseases using metabolomics-based approaches Includes graphical material for metabolomics application that provide useful information for ease of reading of audience
Metabolism And Metabolomics Of Liver In Health And Disease
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Author : Walter Wahli
language : en
Publisher: MDPI
Release Date : 2021-02-19
Metabolism And Metabolomics Of Liver In Health And Disease written by Walter Wahli and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-19 with Science categories.
Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.
Metabolism And Metabolomics Of Liver In Health And Disease
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Author : Walter Wahli
language : en
Publisher:
Release Date : 2021
Metabolism And Metabolomics Of Liver In Health And Disease written by Walter Wahli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.
The Application Of Metabolomics In Human Health And Disease
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Author : Ahmed Alshehri
language : en
Publisher:
Release Date : 2019
The Application Of Metabolomics In Human Health And Disease written by Ahmed Alshehri and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
The study of metabolomic effects of dietary fibres on urinary metabolites from patients with Crohn's disease revealed that each of the 7 dietary fibres did not induce any significant differences in Crohn's disease patients relative to the controls. On the other hand, it was found that metabolites were affected by the time of sample collection post treatment, and the overall effect was that the levels of specific metabolites tended to increase post treatment. The most common pathways affected were those of amino acid metabolism, lipid metabolism, nucleotide metabolism, polyketides, vitamins and cofactors, and xenobiotics, but the effect on carbohydrate metabolism was minimal. Finally, the study to ascertain whether it was possible to predict cancer associated muscle wasting from plasma metabolites in patients with upper gastrointestinal cancer (oesophageal, gastric, pancreatic) revealed that the levels of significantly altered metabolites were generally higher in patients who had lost so much weight (>7.6 kgweight loss). The discriminating metabolites belonged mainly to the lipid metabolic pathways where long chain fatty acids and lysolipids were affected. The observed effects on lipid metabolisms in cancer cachexia suggests that there is an increased tendency towards peroxisomal proliferation in patients who had lost significant muscle mass. Based on these findings, it can be concluded that LC-MS based metabolomics is a valuable tool in discriminating various disease states from the normal physiological state. Although the studies presented in this thesis considered vastly differing physical states ranging from healthy participants performing a simulated ultramarathon exercise on a treadmill to diseased participants suffering from either Crohn's disease or gastrointestinal cancer, the technique was capable of determining the metabolic alterations associated with each disease state. This further reinforces the capacity for metabolomics in discovering new biomarkers for various diseases that could be crucial in the diagnosis, monitoring disease progression, therapeutic efficacy evaluation of novel treatment, and detecting relapses following treatment.
Metabolomics
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-01
Metabolomics written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-01 with Science categories.
This book is mainly for researchers interested in the new developments and applications of metabolomics. It is also important for physicians using metabolomic approaches in the diagnosis of diseases or treatment, and for postgraduate students starting their research projects on metabolomics. The book is divided into two sections as indicated from its title, namely: new insights into biology and new insights into medicine. It gives examples of the different applications of metabolomics from the production of biosurfactants by marine microorganisms to the applications of data from fecal metabolomics, serum metabolomics, and metabolomics of microbiota, as well as the use of Chinese medicines for cancer treatment. Overall, this is a well-written book, containing some very interesting research avenues and cutting-edge approaches. Finally, the editing of this book was of special interest to me and I hope that readers will also find it stimulating.
Plant Metabolomics
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Author : Kazuki Saito
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-29
Plant Metabolomics written by Kazuki Saito and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-29 with Science categories.
Metabolomics – which deals with all metabolites of an organism – is a rapidly-emerging sector of post-genome research fields. It plays significant roles in a variety of fields from medicine to agriculture and holds a fundamental position in functional genomics studies and their application in plant biotechnology. This volume comprehensively covers plant metabolomics for the first time. The chapters offer cutting-edge information on analytical technology, bioinformatics and applications. They were all written by leading researchers who have been directly involved in plant metabolomics research throughout the world. Up-to-date information and future developments are described, thereby producing a volume which is a landmark of plant metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all plant science fields.
A Practical Guide To Metabolomics Applications In Health And Disease
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Author : Julijana Ivanisevic
language : en
Publisher: Springer Nature
Release Date :
A Practical Guide To Metabolomics Applications In Health And Disease written by Julijana Ivanisevic and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Clinical Metabolomics Applications In Genetic Diseases
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Author : Anas M. Abdel Rahman
language : en
Publisher: Springer Nature
Release Date : 2023-10-31
Clinical Metabolomics Applications In Genetic Diseases written by Anas M. Abdel Rahman and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-31 with Medical categories.
This book helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. The book covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms. This model has been successfully applied in various conditions, including inborn errors of metabolism, primary immunodeficiency, and endocrine disorders. However, integrating metabolomics with other omics datasets and clinical phenotypes requires careful study design, analytical tools, and data analysis and interpretation. This groundbreaking new book provides essential guidance for researchers, students, and professionals looking to leverage metabolomics in their own work, including biochemical and clinical geneticists, pharmacogenomics and pharmacometabolomics experts, pharmaceutics and diagnostic researchers, medical scientists, clinical dietitians, metabolic engineers, clinical chemists, and personalized medicine specialists.
A Practical Guide To Metabolomics Applications In Health And Disease
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Author : Julijana Ivanisevic
language : en
Publisher: Springer
Release Date : 2024-02-14
A Practical Guide To Metabolomics Applications In Health And Disease written by Julijana Ivanisevic and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-14 with Medical categories.
This well-accessible textbook constitutes a practical guide to metabolomics approaches and applications in an integrative manner. Illustrated by numerous real-life examples and case studies the book teaches how to set up and carry out metabolomics experiments, from sample collection to storage techniques, and guides the reader through the potentials and challenges of metabolite analysis. In addition, this textbook shows how to obtain insights into molecular mechanisms deployed in different physiological contexts (e.g., exercise, healthy ageing) as well as in different (metabolic) diseases, be it Diabetes, Cancer, Alzheimer ́s Disease, Asthma or others. The book brings together knowledge from biochemical, biological, and medical aspects, and further equips the reader with know-how from sample collection and handling to data processing, analysis and interpretation. This textbook is a must-have for advanced undergraduates and graduate students interested in applied biochemistry and metabolomics, as well as for instructors who teach courses in biomedicine, physiology or biochemistry.