Modelling And Computational Approaches Multi Scale Phenomena In Cancer Research
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Modelling And Computational Approaches Multi Scale Phenomena In Cancer Research
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Author : Raluca Eftimie
language : en
Publisher: Wspc (Europe)
Release Date : 2024
Modelling And Computational Approaches Multi Scale Phenomena In Cancer Research written by Raluca Eftimie and has been published by Wspc (Europe) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with Mathematics categories.
Cancer development and progression is the result of biological phenomena that occur across multiple temporal and spatial scales. Recent years have seen a flurry of multi-scale mathematical models developed to generate and test new biological hypotheses related to cancer development, progression, and various treatment approaches. This has led to the development of new computational and analytical approaches aimed at investigating these multi-scale models. This review volume summarises the state of the art related to the modelling, experimental investigation, and data assimilation of multi-scale phenomena during cancer development, evolution, and treatment, as well as the computational and analytical investigation of the multi-scale models developed to reproduce the biological phenomena. The book also identifies the experimental and theoretical open problems that will have to be addressed in the near future in order to advance this field. Modelling and Computational Approaches for Multi-Scale Phenomena in Cancer Research is an excellent resource for both early career and advanced researchers.
Modelling And Computational Approaches For Multi Scale Phenomena In Cancer Research From Cancer Evolution To Cancer Treatment
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Author : Raluca Eftimie
language : en
Publisher: World Scientific
Release Date : 2024-11-12
Modelling And Computational Approaches For Multi Scale Phenomena In Cancer Research From Cancer Evolution To Cancer Treatment written by Raluca Eftimie and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-12 with Mathematics categories.
Cancer development and progression is the result of biological phenomena that occur across multiple temporal and spatial scales. Recent years have seen a flurry of multi-scale mathematical models developed to generate and test new biological hypotheses related to cancer development, progression, and various treatment approaches. This has led to the development of new computational and analytical approaches aimed at investigating these multi-scale models.This review volume summarises the state of the art related to the modelling, experimental investigation, and data assimilation of multi-scale phenomena during cancer development, evolution, and treatment, as well as the computational and analytical investigation of the multi-scale models developed to reproduce the biological phenomena. The book also identifies the experimental and theoretical open problems that will have to be addressed in the near future in order to advance this field. Modelling and Computational Approaches for Multi-Scale Phenomena in Cancer Research is an excellent resource for both early career and advanced researchers.
Multiscale Cancer Modeling
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Author : Thomas S. Deisboeck
language : en
Publisher: CRC Press
Release Date : 2010-12-08
Multiscale Cancer Modeling written by Thomas S. Deisboeck and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-08 with Mathematics categories.
Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of dat
Routledge Handbook Of The Resource Nexus
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Author : Raimund Bleischwitz
language : en
Publisher: Routledge
Release Date : 2017-12-14
Routledge Handbook Of The Resource Nexus written by Raimund Bleischwitz and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-14 with Business & Economics categories.
In recent years the concept of the resource "nexus" has been both hotly debated and widely adopted in research and policy circles. It is a powerful new way to understand and better govern the myriad complex relationships between multiple resources, actors and their security concerns. Particular attention has been paid to water, energy and food interactions, but land and materials emerge as critical too. This comprehensive handbook presents a detailed review of current knowledge about resource nexus-related frameworks, methods and governance, including a broad set of inter-disciplinary perspectives. Written by an international group of scholars and practitioners, the volume focuses on rigorous research, including tools, methods and modelling approaches to analyse resource use patterns across societies and scales from a "nexus perspective". It also provides numerous examples from political economy to demonstrate how resource nexus frameworks can illuminate issues such as land grabs, mining, renewable energy and the growing importance of economies such as China, as well as to propose lessons and outlooks for sound governance. The volume seeks to serve as an essential reference text, source book and state-of-the-art, science-based assessment of this increasingly important topic – the resource nexus – and its utility in efforts to enhance sustainability of many kinds and implement the United Nations Sustainable Development Goals in an era of environmental and geopolitical change.
Approaching Complex Diseases
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Author : Mariano Bizzarri
language : en
Publisher: Springer Nature
Release Date : 2020-04-17
Approaching Complex Diseases written by Mariano Bizzarri and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-17 with Medical categories.
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Systems Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-08-24
Systems Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-24 with Science categories.
Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
Cancer Modelling And Simulation
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Author : Luigi Preziosi
language : en
Publisher: CRC Press
Release Date : 2003-06-18
Cancer Modelling And Simulation written by Luigi Preziosi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-18 with Mathematics categories.
Understanding how cancer tumours develop and spread is vital for finding treatments and cures. Cancer Modelling and Simulation demonstrates how mathematical modelling and computer simulation techniques are used to discover and gain insight into the dynamics of tumour development and growth. It highlights the benefits of tumour modelling, such as discovering optimal tumour therapy schedules, identifying the most promising candidates for further clinical investigation, and reducing the number of animal experiments. By examining the analytical, mathematical, and biological aspects of tumour growth and modelling, the book provides a common language and knowledge for professionals in several disciplines.
Multiscale Computer Modeling In Biomechanics And Biomedical Engineering
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Author : Amit Gefen
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-07-08
Multiscale Computer Modeling In Biomechanics And Biomedical Engineering written by Amit Gefen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Technology & Engineering categories.
This book reviews the state-of-the-art in multiscale computer modeling, in terms of both accomplishments and challenges. The information in the book is particularly useful for biomedical engineers, medical physicists and researchers in systems biology, mathematical biology, micro-biomechanics and biomaterials who are interested in how to bridge between traditional biomedical engineering work at the organ and tissue scales, and the newer arenas of cellular and molecular bioengineering.
Multi Scale Approaches In Drug Discovery
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Author : Alejandro Speck-Planche
language : en
Publisher: Elsevier
Release Date : 2017-02-14
Multi Scale Approaches In Drug Discovery written by Alejandro Speck-Planche and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-14 with Science categories.
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents. After an introduction to multi-scale approaches outlining the need for and benefits of their use, the book goes on to explore a range of useful techniques and research areas, and their potential applications to this process. Profiling drug binding by thermodynamics, machine learning for predicting enzyme sub-classes, and multitasking models for computer-aided design and virtual compound screening are discussed, before the book goes on to review Alkaloid Menispermaceae leads, natural chemotherapeutic agents and methods for speeding up the design and virtual screening of therapeutic peptides. Flavonoids as multi-target compounds are then explored, before the book concludes with a review of Quasi-SMILES as a novel tool. Collecting together reviews and original research contributions written by leading experts in the field, Multi-Scale Approaches to Drug Discovery highlights cutting-edge approaches and practical examples of their implementation for those involved in the drug discovery process at many different levels. Using the combined knowledge of medicinal, computational, pharmaceutical and bio- chemists, it aims to support growth in the multi-scale approach to promote greater success in the development of new drugs. - Offers practical guidance on ways to implement multiscale approaches for increased efficiency in drug discovery - Draws on the experience of a highly skilled team of authors under the editorial guidance of one of the field's leading experts - Includes cutting-edge techniques at the forefront of medicinal chemistry and drug discovery optimization
Multiscale Modelling In Biomedical Engineering
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Author : Dimitrios I. Fotiadis
language : en
Publisher: John Wiley & Sons
Release Date : 2023-05-05
Multiscale Modelling In Biomedical Engineering written by Dimitrios I. Fotiadis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-05 with Science categories.
Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.