Multiscale Cancer Modeling
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Multiscale Cancer Modeling
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Author : Thomas S. Deisboeck
language : en
Publisher: CRC Press
Release Date : 2010-12-08
Multiscale Cancer Modeling written by Thomas S. Deisboeck and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-08 with Mathematics categories.
Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of dat
Multiscale Modeling Of Cancer
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Author : Vittorio Cristini
language : en
Publisher: Cambridge University Press
Release Date : 2010-09-09
Multiscale Modeling Of Cancer written by Vittorio Cristini and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-09 with Technology & Engineering categories.
Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.
An Introduction To Physical Oncology
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Author : Vittorio Cristini
language : en
Publisher: CRC Press
Release Date : 2017-06-26
An Introduction To Physical Oncology written by Vittorio Cristini and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-26 with Mathematics categories.
Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome. This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient’s clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.
Selected Topics In Cancer Modeling
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Author : Nicola Bellomo
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-10
Selected Topics In Cancer Modeling written by Nicola Bellomo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-10 with Mathematics categories.
This collection of selected chapters offers a comprehensive overview of state-of-the-art mathematical methods and tools for modeling and analyzing cancer phenomena. Topics covered include stochastic evolutionary models of cancer initiation and progression, tumor cords and their response to anticancer agents, and immune competition in tumor progression and prevention. The complexity of modeling living matter requires the development of new mathematical methods and ideas. This volume, written by first-rate researchers in the field of mathematical biology, is one of the first steps in that direction.
Multiscale Models In Mechano And Tumor Biology
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Author : Alf Gerisch
language : en
Publisher: Springer
Release Date : 2018-03-16
Multiscale Models In Mechano And Tumor Biology written by Alf Gerisch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-16 with Mathematics categories.
This book presents and discusses the state of the art and future perspectives in mathematical modeling and homogenization techniques with the focus on addressing key physiological issues in the context of multiphase healthy and malignant biological materials. The highly interdisciplinary content brings together contributions from scientists with complementary areas of expertise, such as pure and applied mathematicians, engineers, and biophysicists. The book also features the lecture notes from a half-day introductory course on asymptotic homogenization. These notes are suitable for undergraduate mathematics or physics students, while the other chapters are aimed at graduate students and researchers.
Multiscale Modeling And Simulation Of Shock Wave Induced Failure In Materials Science
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Author : Martin Oliver Steinhauser
language : en
Publisher: Springer
Release Date : 2018-02-24
Multiscale Modeling And Simulation Of Shock Wave Induced Failure In Materials Science written by Martin Oliver Steinhauser and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-24 with Medical categories.
Martin Oliver Steinhauser deals with several aspects of multiscale materials modeling and simulation in applied materials research and fundamental science. He covers various multiscale modeling approaches for high-performance ceramics, biological bilayer membranes, semi-flexible polymers, and human cancer cells. He demonstrates that the physics of shock waves, i.e., the investigation of material behavior at high strain rates and of material failure, has grown to become an important interdisciplinary field of research on its own. At the same time, progress in computer hardware and software development has boosted new ideas in multiscale modeling and simulation. Hence, bridging the length and time scales in a theoretical-numerical description of materials has become a prime challenge in science and technology.
Multiscale Modelling In Biomedical Engineering
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Author : Dimitrios I. Fotiadis
language : en
Publisher: John Wiley & Sons
Release Date : 2023-05-05
Multiscale Modelling In Biomedical Engineering written by Dimitrios I. Fotiadis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-05 with Science categories.
Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.
Cellular Potts Models
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Author : Marco Scianna
language : en
Publisher: CRC Press
Release Date : 2013-03-26
Cellular Potts Models written by Marco Scianna and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-26 with Mathematics categories.
This work shows how the cellular Potts model can be used as a framework for model building and how extended models can achieve even better biological practicality, accuracy, and predictive power. It focuses on ways to integrate and interface the basic cellular Potts model at the mesoscopic scale with approaches that accurately model microscopic dynamics. These extensions are designed to create a nested and hybrid environment, where the evolution of a biological system is realistically driven by the constant interplay and flux of information between the different levels of description.
Modelling And Computational Approaches For Multi Scale Phenomena In Cancer Research From Cancer Evolution To Cancer Treatment
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Author : Raluca Eftimie
language : en
Publisher: World Scientific Publishing Europe Limited
Release Date : 2024-06-14
Modelling And Computational Approaches For Multi Scale Phenomena In Cancer Research From Cancer Evolution To Cancer Treatment written by Raluca Eftimie and has been published by World Scientific Publishing Europe Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-14 with Mathematics categories.
Cancer development and progression is the result of biological phenomena that occur across multiple temporal and spatial scales. Recent years have seen a flurry of multi-scale mathematical models developed to generate and test new biological hypotheses related to cancer development, progression, and various treatment approaches. This led to the development of new computational and analytical approaches aimed at investigating these multiscale models.This review volume summarises some of the current state of the art related to the modelling, experimental investigation and data assimilation for multiscale phenomena during cancer development, evolution and treatment, as well as computational and analytical investigation of the multi-scale models developed to reproduce the biological phenomena. The book also identifies the experimental and theoretical open problems that will have to be addressed in the near future in order to advance this field. Modelling and Computational Approaches for Multi-scale Phenomena in Cancer Research is an excellent resource for both early career and advanced researchers.
Cell Mechanics
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Author : Arnaud Chauvière
language : en
Publisher: CRC Press
Release Date : 2010-01-27
Cell Mechanics written by Arnaud Chauvière and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-27 with Mathematics categories.
Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior