Molecular Mechanisms Of Membrane Traffic

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Molecular Mechanisms Of Membrane Traffic

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Author : D. James Morre
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Molecular Mechanisms Of Membrane Traffic written by D. James Morre and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.

The study of membrane traffic in reconstituted cell-free systems has generated an unprecedented amount of new information on the biochemistry, molecular biology and genetics of membrane-based molecular events that underly normal and abnormal cellular function. Many of the individual steps have now been isolated and dissected in simple systems that permit detailed molecular analyses of transport mechanisms and their regulation. Reconstituted events of intercompartment transport include inter-membrane recognition, and controlled membrane fusion-fission reactions. Among the many advances is the growi ng awareness of a remarkabl e evolutionary conservation of many of the components involved in the many steps of membrane traffic, this realization has accelerated greatly the pace of progress in the field. This book provides a collection of participant contributions from the 1992 Summer Research Conference, "Mol ecul ar Mechani sms of Membrane Traffi c, " jointly sponsored with NATO by the American Society of Cell Biology. The conference was held May 9-13, at the Airlie Conference Center in the Virginia countryside, near Warrenton. The conference was attended by 158 scientists. A unique feature was the high proportion of young scientists among the participants. Approximately 65% were students, postdoctoral fe 11 ows and young investigators. Each attendee contri buted to the conference with either a pl atform or poster presentation.

Lipid And Protein Traffic

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Author : Jos A.F. Op den Kamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Lipid And Protein Traffic written by Jos A.F. Op den Kamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.

The meeting on "Molecular Mechanisms of Lipid and Protein Traffic", sponsored by NATO Scientific Affairs Division as an Advanced Study Institute and by the Federation of European Biochemical Societies as a Lecture Course was held in Cargese, France, in June 1997. The program included introductory lectures, specialized up-to-date contributions, poster sessions, tutorials and workshops. Emphasis was laid on the new developments in the field of membrane dynamics, in particular on the insertion and translocation of proteins; on intracellular protein, lipid and membrane traffic and sorting and on the mutual interactions between the various events occurring during membrane biogenesis. Mitochondrial biogenesis, chloroplast assembly and the insertion of proteins into peroxisomes were highlighted. Much progress in these research areas has been made in recent years and the ASI provided an excellent opportunity to illustrate this progress in comparison with previous meetings on a similar topic. Not only graduate students and postdocs took advantage from this program but also experienced scientists were given the opportunity to obtain a complete overview of recent progress and the remodeling of ideas and concepts.

Regulatory Mechanisms Of Intracellular Membrane Transport

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Author : Sirkka Keränen
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-08-27

Regulatory Mechanisms Of Intracellular Membrane Transport written by Sirkka Keränen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-27 with Medical categories.

This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular networks that govern these processes. Understanding of regulatory processes and participating molecules are likely to reveal global cellular regulatory circuits that couple membrane trafficking with other cellular functions. Such cell biological features are only starting to emerge. This book puts special emphasis on such mechanisms and processes. The contents discusses the role of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. In addition, the role of lipids in vesicle formation and membrane fusion, and some specialized cell biological denovo membrane generation processes are discussed.

Protein Lipid And Membrane Traffic

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Author : North Atlantic Treaty Organization. Scientific Affairs Division
language : en
Publisher: IOS Press
Release Date : 2000

Protein Lipid And Membrane Traffic written by North Atlantic Treaty Organization. Scientific Affairs Division and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Biological transport categories.

This text concentrates on the following specific topics: the dynamic character of lipids and proteins in biological membranes; the existence of specific domains in membranes including their visualisation; the molecular mechanisms of intracellular transport of membrane constituents and the involvement of lipid-protein interactions in these processes; protein assembly; structure and folding and transport through membranes; and the intracellular sorting and targeting of individual membrane components as well as different organelles."

Regulatory Mechanisms Of Intracellular Membrane Transport

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Author : Sirkka Keränen
language : en
Publisher: Springer
Release Date : 2014-10-08

Regulatory Mechanisms Of Intracellular Membrane Transport written by Sirkka Keränen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-08 with Science categories.

This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular networks that govern these processes. Understanding of regulatory processes and participating molecules are likely to reveal global cellular regulatory circuits that couple membrane trafficking with other cellular functions. Such cell biological features are only starting to emerge. This book puts special emphasis on such mechanisms and processes. The contents discusses the role of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. In addition, the role of lipids in vesicle formation and membrane fusion, and some specialized cell biological denovo membrane generation processes are discussed.

Molecular Biology Of The Cell

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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002

Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.

Overview Of Membrane Trafficking Pathways

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Author : Jill Lynch
language : en
Publisher:
Release Date : 2015-03-31

Overview Of Membrane Trafficking Pathways written by Jill Lynch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-31 with categories.

An overview of membrane trafficking pathways has been provided in this all-inclusive book. Membrane traffic is a wide domain that deals with complex exchange of membranes that occurs inside a cell. Protein, lipids and other molecules travel among intracellular organelles, are delivered to or transferred from the cell surface by virtue of membranous carriers known as "transport intermediates." These carriers have distinct shapes and sizes; and their biogenesis, mode of transport and delivery to the final destination are monitored by a multitude of very intricate molecular mechanisms. The concept that every membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways has emerged in past few years. This book intends to present a general overview of the degree of this crosstalk.

Insight Into The Molecular Mechanisms Of Membrane Geometry Generation And Recognition

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Author : Richard Gill
language : en
Publisher:
Release Date : 2015

Insight Into The Molecular Mechanisms Of Membrane Geometry Generation And Recognition written by Richard Gill and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.

Membrane remodeling is an essential process in cell growth, division, intracellular vesicle transport, and many other essential biological phenomena. Furthermore, membrane geometry has recently been shown to regulate biological activity and determines the final cellular localization of some proteins. The aim of this thesis is to provide structural and molecular insights into the mechanism governing membrane geometry induction and recognition. SpoVM is a small peptide that was recently found to recognize and preferentially localize to the slightly curved outer surface of the forespore (diameter of curvature, R, ~1 [mu]m) during Bacillus subtilis spore development. However, little was known about how this was accomplished. We determined that the SpoVM molecule adopted an atypical amphipathic helical structure in bilayer-like bicelles and that the helix is deeply embedded into the membrane. Our study challenges the current accepted model, which is based on circular dichroism and biochemical data, and provides structural support that SpoVM uses a new molecular mechanism to sense small membrane curvature. Recent studies have linked protein intracellular trafficking to human diseases. In Alzheimer's Disease (AD), a type I membrane protein referred to as LR11 (SorLA) is a key regulator of the amyloid precursor protein (APP) trafficking. LR11 diverts APP away from amyloidogenic processing to A[beta] peptides. The accumulation of A[beta] in the brain is generally accepted as the primary cause of AD. We discovered a membrane proximal amphipathic [alpha]-helix in LR11 C-terminal domain and, moreover, this helix deforms the membrane mimic liposomes. Since changes in membraneivgeometry are inherent to trafficking events, we postulate that this helix may sense and/or induce the bending of the membrane during vesicle biogenesis to facilitate LR11 intracellular transport. Amphipathic helices play a myriad of functions in mediating protein-lipid interactions. Despite their structural simplicity, several key properties including charge, the physiochemical characteristics of the hydrophobic vs. hydrophilic face, hydrophobicity, helical length, membrane orientation, and insertion depth, can be fine-tuned for their biological functions. Our study highlights the importance to quantitatively dissect these parameters in order to mechanistically understand their functions in membrane remodeling and ultimately to be able to manipulate these properties for therapeutic uses such as in designing antimicrobial and cell penetrating peptides.

Membrane Trafficking In Viral Replication

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Author : Mark Marsh
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-10-25

Membrane Trafficking In Viral Replication written by Mark Marsh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-25 with Medical categories.

Viruses are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.

Molecular Mechanisms Of Water Transport Across Biological Membranes

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Author : Wilfred D. Stein
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-04-02

Molecular Mechanisms Of Water Transport Across Biological Membranes written by Wilfred D. Stein and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-02 with Science categories.

International Review of Cytology presents current advances and comprehensive reviews in cell biology--both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. This volume looks at water movements from a wide range of levels. It examines how water interacts with the major components of the cell, including proteins and lipids. It discusses how water moves across cell membranes by diffusion, how it is chanelled across these membranes or, in certain cases, pumped across, and how water movements are controlled. This book demonstrates how water and ion movements are closely linked in order to provide a better understanding of their behavior. *Essential Physical chemistry of water at biological interfaces *Up-to-date reviews of water behavior in cells *Water in integrated systems *Current information on water channels across membranes