Molecular Mimicry And Its Effect On Crohn S Disease
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Molecular Mimicry And Its Effect On Crohn S Disease
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Author : Patrick Kimuyu
language : en
Publisher: GRIN Verlag
Release Date : 2018-02-01
Molecular Mimicry And Its Effect On Crohn S Disease written by Patrick Kimuyu and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-01 with Medical categories.
Scientific Essay from the year 2018 in the subject Medicine - Medical Frontiers and Special Areas, grade: 1.2, Egerton University, language: English, abstract: Molecular mimicry is a well-documented biological phenomenon and its link to autoimmune diseases has led to extensive research. From an epidemiological perspective, autoimmune diseases have been found to exhibit multifactorial origins. In most cases, genetic predisposition, as well as environmental factors leads to tissue injury owing to the activity of autoreactive antibodies or T cells. One of the most striking characteristics of autoimmune diseases is that the initial biological processes that lead to the loss of tolerance do not match with clinical manifestations. These manifestations occur long after the mechanisms associated with loss of tolerance. It is believed that loss of tolerance is responsible for the severity of chronic autoimmune diseases. Currently, there are several pathological processes involved in the breakdown of immunologic tolerance. These mechanisms include activation of polyclonal lymphocytes, abnormalities in self antigens presentation, molecular mimicry, and presence of autoreative lymphocytes (Bellone, 2005). In Crohn’s disease, as well as other autoimmune diseases such as ulcerative colitis, multiple sclerosis, and type 1 diabetes mellitus, molecular mimicry is hypothesized to be one of the key mechanisms leading to the breakdown of immunological self tolerance. Therefore, this paper will provide a comprehensive overview on molecular mimicry and its effects on autoimmune diseases with a principal focus on Crohn’s disease.
Crohn S Disease
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Author : Toney Allman
language : en
Publisher: Greenhaven Publishing LLC
Release Date : 2011-12-01
Crohn S Disease written by Toney Allman and has been published by Greenhaven Publishing LLC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-01 with Young Adult Nonfiction categories.
Crohn's disease is a type of inflammatory bowel disease in which an abnormal immune system response causes chronic inflammation in the digestive tract. About 1.4 million Americans have Crohn's disease or ulcerative colitis. This essential volume explains this disease in detail, covering its diagnosis, treatments and therapies, and medical advances. Readers will also hear from individuals who live with this challenging disease.
Understanding Crohn S Disease Immunity Genes And Microbes
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Author : Amélia Sarmento
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-11
Understanding Crohn S Disease Immunity Genes And Microbes written by Amélia Sarmento and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-11 with Electronic book categories.
Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactorial depending on genetic and environmental determinants. In recent years, nearly 100 single nucleotide polymorphisms (SNPs) were associated with increased risk of developing CD (some of the SNPs also associated with susceptibility to ulcerative colitis, another type of IBD). These SNPs are mostly located in genes involved in innate and adaptive immunity mechanisms, such as autophagy, expression of pattern-recognition receptors and citokine signaling. Epigenetics is also probably playing a role in CD susceptibility, as it is sensitive to environmental conditions and may mediate gene-environment interactions. Environmental factors possibly involved in CD development include diet, gut microbiota composition and infection with specific pathogens, of which the most consistently associated to CD are Mycobacterium avium subsp. paratuberculosis and adherent-invasive Escherichia coli. This Topic aimed at bringing together contributions covering different genetic, epigenetic, immunological and microbial processes involved in the development of CD, helping to drive forward the understanding of CD immunopahtology.
Nutrition And Immunity
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Author : Maryam Mahmoudi
language : en
Publisher: Springer
Release Date : 2019-07-30
Nutrition And Immunity written by Maryam Mahmoudi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-30 with Medical categories.
This volume provides readers with a systematic assessment of current literature on the link between nutrition and immunity. Chapters cover immunonutrition topics such as child development, cancer, aging, allergic asthma, food intolerance, obesity, and chronic critical illness. It also presents a thorough review of microflora of the gut and the essential role it plays in regulating the balance between immune tolerance and inflammation. Written by experts in the field, Nutrition and Immunity helps readers to further understand the importance of healthy dietary patterns in relation to providing immunity against disorders and offering readily available immunonutritional programming in clinical care. It will be a valuable resource for dietitians, immunologists, endocrinologists and other healthcare professionals.
Translational Autoimmunity Volume 1
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Author : Nima Rezaei
language : en
Publisher: Academic Press
Release Date : 2021-10-22
Translational Autoimmunity Volume 1 written by Nima Rezaei and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-22 with Medical categories.
Translational Autoimmunity: Etiology of Autoimmune Diseases is the first volume of the Translational Immunology book series. To attain its purpose as a detailed translational step to tackle autoimmunity, this volume sufficiently addresses basic questions on how the immune system is designed to distinguish self from nonself. It discusses the known mechanisms that lead to the maintenance of self-tolerance, presents potential triggers and malfunctions that impede normal immune processes, and demonstrates how the immune system induces an autoreactive state that results in the recognition of self-antigens seen in autoimmune conditions. Includes coverage of basic immunology, the clinical aspects of autoimmunity, and translational immunology studies in autoimmunity Presents key concepts supported by a systematic appraisal of the most recent evidence Assists students at all the academic levels while also being applicable to scientists who work with autoimmunity Designed for learning, teaching, review, testing, practice and research
Autoimmunity Covid 19 Post Covid19 Syndrome And Covid 19 Vaccination
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Author : Yehuda Shoenfeld
language : en
Publisher: Elsevier
Release Date : 2022-12-03
Autoimmunity Covid 19 Post Covid19 Syndrome And Covid 19 Vaccination written by Yehuda Shoenfeld and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-03 with Medical categories.
Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community. Describe the short and long impact of COVID-19 on autoimmunity Provides understanding to the acute and chronic impact of the SARS-CoV-2 Gives insights into the long-term effects of COVID-19 on recovered patients Provides conclusions on the novel terms "chronic post-COVID-19 syndrome", "post-acute COVID-19 syndrome", and "long COVID-19"
Crohn S Disease And Ulcerative Colitis
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Author : Daniel C. Baumgart
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-28
Crohn S Disease And Ulcerative Colitis written by Daniel C. Baumgart and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-28 with Medical categories.
The conditions of Crohn’s disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient’s quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are sometimes complex and associated with important risks requiring a deeper understanding of their molecular principles from clinicians. Crohn’s Disease and Ulcerative Colitis serves as a unique combined resource for physicians and scientists addressing the needs of both groups. It will stimulate exchange and collaboration and shorten the path between discovery and application of new knowledge and also help clinicians understand new therapeutic concepts from their origins. This volume provides an introduction to mucosal immunology which forms the basis of modern immunotherapy. It also serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy as well as conventional and complex immunomodulatory principles. Each chapter is written by experts in their field and includes the most up to date information. Crohn’s Disease and Ulcerative Colitis will be of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis and related autoimmune disorders.
Psp94 What Is It Good For
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Author : Martin Laurence
language : en
Publisher: Shipshaw Labs
Release Date : 2018-06-30
Psp94 What Is It Good For written by Martin Laurence and has been published by Shipshaw Labs this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-30 with Medical categories.
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Clinical Naturopathic Medicine Ebook
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Author : Leah Hechtman
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-06-03
Clinical Naturopathic Medicine Ebook written by Leah Hechtman and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-03 with Medical categories.
Clinical Naturopathic Medicine is a foundation clinical text integrating the holistic traditional principles of naturopathic philosophy with the scientific rigour of evidence-based medicine (EBM) to support contemporary practices and principles. The text addresses all systems of the body and their related common conditions, with clear, accessible directions outlining how a practitioner can understand health from a naturopathic perspective and apply naturopathic medicines to treat patients individually. These treatments include herbal medicine, nutritional medicine and lifestyle recommendations. All chapters are structured by system and then by condition, so readers are easily able to navigate the content by chapter and heading structure. The content is designed for naturopathic practitioners and students (both undergraduate and postgraduate levels) and for medical and allied health professionals with an interest in integrative naturopathic medicine. detailed coverage of naturopathic treatments provides readers with a solid understanding of the major therapeutic modalities used within naturopathic medicine each system is reviewed from both naturopathic and mainstream medical perspectives to correlate the variations and synergies of treatment only clinically efficacious and evidence-based treatments have been included information is rigorously researched (over 7500 references) from both traditional texts and recent research papers the content skilfully bridges traditional practice and EBM to support confident practitioners within the current health care system
Molecular Mimicry
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Author : Michael B.A. Oldstone
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12
Molecular Mimicry written by Michael B.A. Oldstone and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Medical categories.
This volume focuses on the evidence for or against molecular mimicry as a cause of autoimmunity. Contributions from recognized experts present their original findings, and the final chapter reviews the overall perspective of molecular mimicry, how to use its principles in clinical investigation and list the conceptual traits by which autoimmune disaese can occur.