Molecular Pathway Analysis Using High Throughput Omics Molecular Data
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Molecular Pathway Analysis Using High Throughput Omics Molecular Data
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Author : Anton Buzdin
language : en
Publisher: Elsevier
Release Date : 2024-10-26
Molecular Pathway Analysis Using High Throughput Omics Molecular Data written by Anton Buzdin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-26 with Science categories.
The field molecular pathway analysis evolves rapidly, and many progressive methods have recently been discovered. Molecular Pathway Analysis Using High-Throughput OMICS Data contains the largest collections of molecular pathways. For the first time, guidelines on how to do genomic, epigenetic, transcriptomic, proteomic, and metabolomic data analysis in real-world research practice are given. Molecular Pathway Analysis Using High-Throughput OMICS Molecular Data also focuses on the pathway analysis applications for solving tasks in biotechnology, pharmaceutics, and molecular diagnostics It demonstrates how pathway analysis can be applied for the research and treatment of chronic and acute diseases, for next-generation molecular diagnostics, for drug design and preclinical testing; relevant real-world examples, molecular tests, and web resources will be reviewed in-depth. The book shows a tendency of erasing the borders between chemistry, physics, informatics, mathematics, biology, and medicine by means of novel research approaches and instruments, providing a truly multidisciplinary approach. - Provides theoretical insights, links to available resources and their descriptions, and protocols related to multiple possibilities and options of the molecular pathway analysis - Elucidates unique instruments (i) for the quantitative pathway analysis using metabolomic data, and (ii) for algorithmic hypothesis-free reconstruction and functional annotation of the molecular pathways that have a strong potential to revolutionize the field - Includes intuitive practical guidelines on the analysis of genomic, epigenetic, transcriptomic, proteomic, and metabolomic data at the molecular pathway level for non-bioinformaticians - Provides state-of-the art in the field of Big molecular data analysis for research, medicine, biotechnology, pharmaceutics, and next-generation molecular diagnostics
Evolution Of Translational Omics
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2012-09-13
Evolution Of Translational Omics written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-13 with Science categories.
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Handbook Of Translational Transcriptomics
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Author : Anton Buzdin
language : en
Publisher: Academic Press
Release Date : 2025-05-16
Handbook Of Translational Transcriptomics written by Anton Buzdin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-16 with Science categories.
Handbook of Translational Transcriptomics: Research, Protocols and Applications provides a comprehensive overview of the field of transcriptomics. With an emphasis on the various protocols and techniques available for investigation, it acts as a practical guide to researchers for implementing their own investigations in the field.This book begins with an overview of the past, present, and potential approaches in the field of transcriptomics, with discussions of choosing the correct approach based on the research needed. It also highlights the pros and cons of each approach. Following this, it explores techniques and protocols for investigating specific approaches focusing on RNA sequencing, expression arrays, and gene expression. It then delves into data analysis and offers recommendations, guidelines, and approaches related to data interpretation. This book also considers the translation of transcriptomics to clinical use and applications in molecular diagnostics, biomarkers in medicine, and personalized medicine specific to oncology, as well as biotechnology for pharmaceutical research.Handbook of Translational Transcriptomics: Research, Protocols and Applications is a detailed reference that provides a complete view of transcriptomics, ranging from methods to handling data and medical applications. This book is an invaluable guide for researchers working across molecular biology, genetics, bioinformatics and related fields, as well as graduate and PhD students in these areas. - Features practical guidance and protocols for researchers to replicate transcriptomic methods and techniques, including wet lab techniques. - Includes useful information on analyzing and interpreting transcriptomic data. - Offers a detailed introduction into translational transcriptomics, exploring both coding and noncoding RNAs including microRNA. - Investigates clinical implications of transcriptomics and applications to treating disease. - Considers some experimental and bioinformatic techniques in the field of transcriptomics, as well as more established approaches.
Systems Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-08-24
Systems Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-24 with Science categories.
Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
Recent Advances In Precision Vaccine Discovery Development
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Author : Ofer Levy
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-23
Recent Advances In Precision Vaccine Discovery Development written by Ofer Levy and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-23 with Medical categories.
Topic Editor Jay Evans is the co-founder, President and CEO of Inimmune Corporation. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Application And Innovation Of Multiomics Technologies In Clinical Oncology
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Author : Ye Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-26
Application And Innovation Of Multiomics Technologies In Clinical Oncology written by Ye Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-26 with Science categories.
Multiple Sclerosis Immunology
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Author : Takashi Yamamura
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-09-14
Multiple Sclerosis Immunology written by Takashi Yamamura and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-14 with Medical categories.
The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the “new” MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and—even more—the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that “translation” is real and not just virtual.
Pathway Analysis For Drug Discovery
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Author : Anton Yuryev
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-17
Pathway Analysis For Drug Discovery written by Anton Yuryev and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-17 with Science categories.
This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.
Cutting Edge Diagnostic Technologies In Cardiovascular Diseases
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Author : Haipeng Liu
language : en
Publisher: CRC Press
Release Date : 2025-06-23
Cutting Edge Diagnostic Technologies In Cardiovascular Diseases written by Haipeng Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-23 with Technology & Engineering categories.
This book provides a comprehensive overview of cutting-edge technologies in the diagnosis of multiple cardiovascular disease. Readers will understand technical advancements and research gaps, which will help them to optimize the design of algorithms and devices. Cutting-Edge Diagnostic Technologies in Cardiovascular Diseases: Towards Data-Driven Smart Healthcare provides details on the adoption and implementation of advanced diagnostic techniques in different clinical settings, including population screening, clinical diagnosis, risk prediction, data-driven diagnosis, and remote healthcare monitoring. It also covers various cardiovascular diseases, from the macrovascular to microvascular levels, where early and accurate diagnosis is a high clinical need, for example, stroke, intracranial atherosclerosis, coronary artery disease, and microvascular dysfunction. The book is a practical guide with case studies, and the authors cover a wide range of cutting-edge diagnostic techniques, including artificial intelligence, radiological imaging, wearable sensors, genetic biomarkers, and multi-omics data integration. It summarizes the potentials, challenges, and ethical concerns in the implementation of these techniques under current clinical settings. It also discusses the future directions and perspectives for next-generation diagnostics based on AI-enhanced multimodal data fusion. This book targets a mixed audience of data scientists, engineers, clinicians, researchers, academics, and students interested in cutting-edge technologies, methodologies, and practices in the diagnostics of cardiovascular diseases to resolve the challenging gaps in healthcare and clinical applications.
Current Omics Advancement In Plant Abiotic Stress Biology
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Author : Deepesh Bhatt
language : en
Publisher: Elsevier
Release Date : 2024-05-07
Current Omics Advancement In Plant Abiotic Stress Biology written by Deepesh Bhatt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-07 with Science categories.
Applied Biotechnology Strategies to Combat Plant Abiotic Stress investigates the causal molecular factors underlying the respective mechanisms orchestrated by plants to help alleviate abiotic stress in which Although knowledge of abiotic stresses in crop plants and high throughput tools and biotechnologies is avaiable, in this book, a systematic effort has been made for integrating omics interventions across major sorts of abiotic stresses with special emphasis to major food crops infused with detailed mechanistic understanding, which would furthermore help contribute in dissecting the interdisciplinary areas of omics-driven plant abiotic stress biology in a much better manner. In 32 chapters Applied Biotechnology Strategies to Combat Plant Abiotic Stress focuses on the integration of multi-OMICS biotechnologies in deciphering molecular intricacies of plant abiotic stress namely drought, salt, cold, heat, heavy metals, in major C3 and C4 food crops. Together with this, the book provides updated knowledge of common and unique set of molecular intricacies playing a vital role in coping up severe abiotic stresses in plants deploying multi-OMICS approaches This book is a valuable resource for early researchers, senior academicians, and scientists in the field of biotechnology, biochemistry, molecular biology, researchers in agriculture and, crops for human foods, and all those who wish to broaden their knowledge in the allied field. - Describes biotechnological strategies to combat plant abiotic stress - Covers the latest evidence based multipronged approaches in understanding omics perspective of stress tolerance - Focuses on the integration of multi-OMICS technologies in deciphering molecular intricacies of plant abiotic stress