Moonlighting Proteins
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Protein Moonlighting In Biology And Medicine
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Author : Brian Henderson
language : en
Publisher: John Wiley & Sons
Release Date : 2016-12-12
Protein Moonlighting In Biology And Medicine written by Brian Henderson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-12 with Science categories.
The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.
Moonlighting Proteins
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Author : Brian Henderson
language : en
Publisher: John Wiley & Sons
Release Date : 2017-03-14
Moonlighting Proteins written by Brian Henderson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-14 with Science categories.
Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.
Moonlighting Cell Stress Proteins In Microbial Infections
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Author : Brian Henderson
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-08
Moonlighting Cell Stress Proteins In Microbial Infections written by Brian Henderson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-08 with Medical categories.
Microbial infection is increasingly seen as a problem as we begin to run out of antibiotics. Understanding how microbes cause disease is essential. In recent years it has begun to emerge that bacteria, fungi, protozoa and viruses can use their cell stress proteins to cause infection. This volume brings together the world's leading experts in the study of the microbial and human cell stress proteins that are involved in enabling microorganisms to infect humans and cause serious disease.
Glyceraldehyde 3 Phosphate Dehydrogenase Gapdh
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Author : Michael A. Sirover
language : en
Publisher: Academic Press
Release Date : 2017-05-22
Glyceraldehyde 3 Phosphate Dehydrogenase Gapdh written by Michael A. Sirover and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Science categories.
Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein’s diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease. Contextualizes how GAPDH is utilized by cells in vivo Provides detailed insight into GAPDH post-translational modifications, including functional diversity and its subcellular localization Includes forward-thinking exposition on tough topics, such as the exploration of how GAPDG performs functions, how it decides where it should be present and requisite structural requirements
Cryptic Enzymes And Moonlighting
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Author : Helen Irving
language : en
Publisher: Academic Press
Release Date : 2025-01-01
Cryptic Enzymes And Moonlighting written by Helen Irving and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-01 with Science categories.
Cryptic Enzymes and Moonlighting, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signalling cascades. It explores recent advances in research, and brings together an array of information across different fields to enable better targeting of these exciting enzymes and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, the book considers examples of cryptic enzymes across species, as well in human healthy biology and pathogenesis. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signalling, metabolic enzyme moonlighting, and RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades.
Biocatalysis
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Author : Andreas S. Bommarius
language : en
Publisher: John Wiley & Sons
Release Date : 2007-02-27
Biocatalysis written by Andreas S. Bommarius and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-27 with Science categories.
The whole range of biocatalysis, from a firm grounding in theoretical concepts to in-depth coverage of practical applications and future perspectives. The book not only covers reactions, products and processes with and from biological catalysts, but also the process of designing and improving such biocatalysts. One unique feature is that the fields of chemistry, biology and bioengineering receive equal attention, thus addressing practitioners and students from all three areas.
Heat Shock Protein 90 In Human Diseases And Disorders
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2019-11-04
Heat Shock Protein 90 In Human Diseases And Disorders written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-04 with Science categories.
The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Structure And Intrinsic Disorder In Enzymology
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Author : Munishwar Nath Gupta
language : en
Publisher: Elsevier
Release Date : 2022-11-17
Structure And Intrinsic Disorder In Enzymology written by Munishwar Nath Gupta and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-17 with Science categories.
Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs. Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study Features chapter contributions from international leaders in the field
Protein Structure And Function
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Author : Gregory A. Petsko
language : en
Publisher: New Science Press
Release Date : 2004
Protein Structure And Function written by Gregory A. Petsko and has been published by New Science Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Each title in the 'Primers in Biology' series is constructed on a modular principle that is intended to make them easy to teach from, to learn from, and to use for reference.
Cellular Trafficking Of Cell Stress Proteins In Health And Disease
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Author : Brian Henderson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-19
Cellular Trafficking Of Cell Stress Proteins In Health And Disease written by Brian Henderson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-19 with Medical categories.
Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.