Mouse Phenotypes
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Mouse Phenotypes
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Author : Virginia E. Papaioannou
language : en
Publisher: CSHL Press
Release Date : 2005
Mouse Phenotypes written by Virginia E. Papaioannou and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step–by–step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.
Mouse Phenotypes
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Author : Papaioannou/Behringe
language : en
Publisher:
Release Date : 2023
Mouse Phenotypes written by Papaioannou/Behringe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Nature categories.
"The laboratory mouse is an important model in biomedical research. This volume provides the concepts and tools needed to generate mutant mice and analyze their phenotypes"--
Mouse Phenotypes
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Author : Virginia E. Papaioannou
language : en
Publisher:
Release Date : 2023
Mouse Phenotypes written by Virginia E. Papaioannou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Animal mutation categories.
"The laboratory mouse is an important model in biomedical research. This volume provides the concepts and tools needed to generate mutant mice and analyze their phenotypes"--
Standards Of Mouse Model Phenotyping
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Author : Martin Hrabé de Angelis
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-03
Standards Of Mouse Model Phenotyping written by Martin Hrabé de Angelis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-03 with Science categories.
This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.
Mouse Phenotypes
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Author : Virginia E. Papaioannou
language : en
Publisher:
Release Date : 2023
Mouse Phenotypes written by Virginia E. Papaioannou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Animal mutation categories.
"The laboratory mouse is an important model in biomedical research. This volume provides the concepts and tools needed to generate mutant mice and analyze their phenotypes"--
Morphological Mouse Phenotyping
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Author : Jesus Ruberte
language : en
Publisher: Elsevier
Release Date : 2017-01-27
Morphological Mouse Phenotyping written by Jesus Ruberte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-27 with Medical categories.
Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man. Features more than 2,200 original images showing the anatomy, histology, and cellular structure of mouse organs Includes images specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona) Offers an integrative vision of mouse morphology using correlative X-ray, computed tomography, magnetic resonance, and ultrasound images Employs classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, and histological, immunohistochemical, and electron microscopy techniques to characterize mouse morphology
What S Wrong With My Mouse
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Author : Jacqueline N. Crawley
language : en
Publisher: John Wiley & Sons
Release Date : 2007-03-23
What S Wrong With My Mouse written by Jacqueline N. Crawley and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-23 with Science categories.
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
Behavioral Genetics Of The Mouse Volume 1 Genetics Of Behavioral Phenotypes
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Author : Wim E. Crusio
language : en
Publisher: Cambridge University Press
Release Date : 2013-04-25
Behavioral Genetics Of The Mouse Volume 1 Genetics Of Behavioral Phenotypes written by Wim E. Crusio and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-25 with Science categories.
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Morphological Mouse Phenotypin
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Author : Jesus Ruberte
language : en
Publisher: Academic Press
Release Date : 2016-12-15
Morphological Mouse Phenotypin written by Jesus Ruberte and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-15 with Medical categories.
Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypothesis has encouraged the development of massive global projects making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans. However, a mouse is not a man. Here we present a complete and integrative description of mouse normal morphology. This book, basically an atlas, but also containing explanatory diagrams and text, guides the reader through normal mouse anatomy, histology and imaging, and is aimed for mouse researchers as well as veterinarian and human pathologists. More than 2,200 original images showing the anatomy, histology and cellular structure of mouse organs have been specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona) In addition, correlative X-ray, Computed Tomography, Magnetic Resonance and Ultrasound images complete this integrative vision of the mouse morphology Classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, as well as histological, immunohistochemical and electron microscopy techniques have been employed to characterize the mouse morphology "
Mutagenesis Of The Mouse Genome
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Author : Monica Justice
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-12
Mutagenesis Of The Mouse Genome written by Monica Justice and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-12 with Science categories.
The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill’s research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.