Mutagenesis Of The Mouse Genome
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Mutagenesis Of The Mouse Genome
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Author : Monica Justice
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-12
Mutagenesis Of The Mouse Genome written by Monica Justice and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-12 with Science categories.
The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill’s research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.
Genetics Of The Mouse
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Author : Jean Louis Guénet
language : en
Publisher: Springer
Release Date : 2014-11-29
Genetics Of The Mouse written by Jean Louis Guénet and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-29 with Science categories.
This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
Functional Genomics In Mice By Microarray Coupled Gene Trap Mutagenesis
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Author : Weisheng Victor Chen
language : en
Publisher:
Release Date : 2004
Functional Genomics In Mice By Microarray Coupled Gene Trap Mutagenesis written by Weisheng Victor Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Genomes categories.
The Mouse In Animal Genetics And Breeding Research
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Author : Eugene J Eisen
language : en
Publisher: World Scientific
Release Date : 2005-06-27
The Mouse In Animal Genetics And Breeding Research written by Eugene J Eisen and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-27 with Science categories.
The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields.
Mouse Genetics And Transgenics
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Author : Ian J. Jackson
language : en
Publisher: OUP Oxford
Release Date : 1999-12-09
Mouse Genetics And Transgenics written by Ian J. Jackson and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-09 with Science categories.
A unique book that integrates knowledge from a wide range of expertise, specifically applied to the mouse, and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: APA covers all aspects of using the mouse as a genetic model organism: care & husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; and gene targetting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.
Gene Knockout Protocols
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Author : Ralf Kühn
language : en
Publisher: Humana Press
Release Date : 2014-10-30
Gene Knockout Protocols written by Ralf Kühn and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-30 with Science categories.
Following the completion of the mouse and human genome sequences, a major challengeisthefunctionalcharacterizationofeverymammaliangeneandthedeciph- ing of their molecular interaction network. The mouse offers many advantages for the use of genetics to study human biology and disease, unmatched among other m- mals. Its development, body plan, physiology, behavior, and diseases have much in common, based on the fact that 99% of the human genes have a mouse ortholog. The investigation of gene function using mouse models is based on many years of tech- logical development. In the two decades since gene targeting in murine embryonic stem (ES) cells was first described by Mario Capecchi and colleagues, more than 3000 predesigned mouse mutants have been developed. To date, a variety of mouse mutagenesis techniques, either gene- or phenotype-driven, are used as systematic approaches. The availability of the genome sequence supports gene-driven approaches such as gene-trap and targeted mutagenesis in ES cells, allowing efficient and precise gene disruption. In combination with the use of site-specific DNA recombinases, in particular the Cre/loxP system, gene disruptioncan be directed to specific cell types in conditionalmousemutants. Furthermore,chemicalandtransposonmutagenesisofthe mouse genome enables us to perform phenotype-driven screens for the unbiased identification of phenotype–genotype correlations involved in models of human d- ease. Over the next several years, the mouse genome will be systematically altered, and the techniques for achieving predesigned manipulations will be constantly developed further and improved. The second edition of Gene Knockout Protocols brings together distinguished c- tributorswithextensiveexperienceinthegenetargetingandmousegeneticsfields.
Conditional Mutagenesis An Approach To Disease Models
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Author : Robert Feil
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-01
Conditional Mutagenesis An Approach To Disease Models written by Robert Feil and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-01 with Medical categories.
In this book, leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse and their application to model human physiology and pathophysiology. The book illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. In addition, it considers the development of new drugs to treat human diseases.
Animal Models For The Study Of Human Disease
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Author : Yoichi Gondo
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by Yoichi Gondo and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
To create and establish mutant mice as models for human diseases and traits, various forward and reverse genetics tools are currently available. Newly developed tools of high-throughput identification of novel mutations and site-directed mutagenesis, or gene targeting, in the mouse genome have caused forward and reverse genetics, respectively, to rapidly expand during the last two decades. Worldwide efforts including a variety of international consortiums have been producing many useful mutant mouse strains for functional genomics to elucidate the mechanisms behind diseases and traits. Resource centers and public databases have also been built to enhance their utilities. The modeling has started from Mendelian monogenic traits and has expanded to more complex quantitative traits as well. Multidisciplinary integration among, for example, molecular, cellular, and developmental biology; genetics; genomics; medicine; statistics; and informatics must be orchestrated to fully utilize the resources and knowledge of model mice.
Mouse Phenotypes
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Author : Virginia E. Papaioannou
language : en
Publisher: CSHL Press
Release Date : 2005
Mouse Phenotypes written by Virginia E. Papaioannou and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step–by–step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.
Stress Induced Mutagenesis
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Author : David Mittelman
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12
Stress Induced Mutagenesis written by David Mittelman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Medical categories.
The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes. This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.