Neuroprotective Agents
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Neuroprotective Agents
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Author : William Slikker
language : en
Publisher:
Release Date : 2001
Neuroprotective Agents written by William Slikker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
An international group of scientists in both clinical and basic research in neuroprotective agents examine the effects of and therapy for spinal cord injury; inflammatory responses in intracerebral hemorrhage; neurotoxicity and genetic damage from amphetamine abuse; effects of marijuana abuse; cerebrovascular deficits; effects of and therapy for ischemic stroke; distribution of microglia in ageing brain and after transgenic manipulation; preconditioning gene induction for neuroprotection against oxidative stress; interaction of genes and environment in the expression and treatment of autism in an animal model; pathology and pharmacology of spreading depression. The volume also examines proposed designs and strategies for neuroprotection trials.
Neuroprotective Agents And Cerebral Ischaemia
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Author :
language : en
Publisher: Academic Press
Release Date : 1996-11-26
Neuroprotective Agents And Cerebral Ischaemia written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-26 with Science categories.
Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes. Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs. Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs Discusses the application of preclinical data to formulate approaches to a clinical problem Provides detailed reviews of both completed clinical trials and those currently underway
Neuroprotective Agents
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Author : William Slikker
language : en
Publisher:
Release Date : 1997
Neuroprotective Agents written by William Slikker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
This volume of conference papers from the Third International Conference on Neuroprotective Agents, clarifies the physical and biochemical mechanisms underlying neuronal injury and cell death following ischemia and traumatic injury. It defines current concepts of clinical syndromes that may be ameliorated by neuroprotective agents, and describes proposed mechanisms, therapeutic actions, toxicity, and clinical applications of the various neuroprotective agents currently under study. It also brings attention to new agents and classes of agents, including endogenous neuroprotectants that have shown recent promise. Finally, it includes reports on recent clinical trials and suggests possible refinements for future such trials and safety.
Discovery And Development Of Neuroprotective Agents From Natural Products
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Author : Goutam Brahmachari
language : en
Publisher: Elsevier
Release Date : 2017-05-18
Discovery And Development Of Neuroprotective Agents From Natural Products written by Goutam Brahmachari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-18 with Science categories.
Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab
Neuroprotective Agents
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Author : Bruce Trembly
language : en
Publisher:
Release Date : 1995
Neuroprotective Agents written by Bruce Trembly and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Lake George, NY categories.
This volume describes the use of both short- and long-term treatment of such neuroprotective agents as calcium channel antagonists, adenosine, cannabinoids, and NMDA receptor antagonists in cerebral ischaemia, hypoxia, head trauma, and neurotrauma, among other pathologic conditions. Further study is made of reactive oxygen species in neuronal degeneration and free radical mechanisms and neuroprotective antioxidants.
Neuroprotective Agents
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Author : William Slikker
language : en
Publisher:
Release Date : 2005
Neuroprotective Agents written by William Slikker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Nervous system categories.
Contributions from clinical and basic science researchers from many countries and disciplines address various approaches to providing neuroprotection. This book introduces technologies for describing both the insult and the treatment necessary for neuroprotection, including gene express assays (genomics) and gene therapy.
Cns Neuroprotection
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Author : Frank W. Marcoux
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Cns Neuroprotection written by Frank W. Marcoux and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer's disease will be treated effectively by therapeutic neuroprotective strategies. This volume of the Handbook of Experimental Pharmacology titled eNS Neuroprotection provides a pharmacological perspective on currently promis ing neuroprotective approaches, and a clinical perspective on the challenges involved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagues, Washington University School of Medicine, review the status of blocking excitotoxicity as an approach to CNS neuroprotection. Dr. WANG, Pfizer Global Research and Development,Ann Arbor Laboratories, outlines evidence supporting a contri bution of apoptosis to pathological neuronal or glial cell loss. Drs. BECKER and HALLENBECK, University of Washington and the National Institute on Neuro logical Diseases and Stroke, respectively, argue that inhibiting inflammatory pathways in the brain can be neuroprotective. Dr.
The Handbook Of Neuroprotection
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Author : Kewal K. Jain
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-14
The Handbook Of Neuroprotection written by Kewal K. Jain and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-14 with Medical categories.
Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative against the progression of the underlying disease, as well as regenerative. The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of neurological disorders. Neuroprotective effects of older, established drugs, as well as new drugs in development, are well documented in this detailed volume, featuring the most cutting-edge and innovative methods currently in use. In-depth and authoritative, The Handbook of Neuroprotection features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.
Immunosuppressant Analogs In Neuroprotection
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Author : Cesario V. Borlongan
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-11-20
Immunosuppressant Analogs In Neuroprotection written by Cesario V. Borlongan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-20 with Medical categories.
An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents". The book focuses on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders.
Neuroprotective Agents
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Author : William Slikker, Jr
language : en
Publisher: Wiley-Blackwell
Release Date : 2005-09-23
Neuroprotective Agents written by William Slikker, Jr and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-23 with Medical categories.
As life expectancy has increased, so has the incidence of neurodegenerative diseases, particularly those associated with aging. Contributing to increased life expectancy is increased survival following brain injury, stroke, and procedures such as heart surgery, but these events can impair neurological function. The wide range of contributions to this volume, from a detailed paper on the use of gene therapy in combination with hypothermia for the treatment of cerebral ischemia to a comprehensive poster describing the role of anesthetic agents in neurotoxicity during development and senescence, illustrate the scientific scope presented. Contributions from clinical and basic science researchers from many disciplines address various approaches to providing neuroprotection. The clinical focus is on the complexity of neuroprotection, the need for understanding the time-course effects of hypoxia/ischemia, and the need for combinational and time-course applications of multiple therapies. New technologies are introduced for describing both the insult and the treatment necessary for neuroprotection, including gene expression assays (genomics) and gene therapy. Several chapters are devoted to the examination of the predictive value of models for outcome measures in clinical ischemic stroke neuroprotective trials. The need to move from in vitro models to more predictive in vivo approaches with the use of pharmacokinetics is addressed. Other chapters emphasize the role of endogenous agents such as nitric oxide, melatonin, L-carnitine, and estrogens in acute and chronic neural injury and therapy. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.