Neuroprotective Agents And Cerebral Ischaemia


Neuroprotective Agents And Cerebral Ischaemia
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Neuroprotective Agents And Cerebral Ischaemia


Neuroprotective Agents And Cerebral Ischaemia
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Author :
language : en
Publisher: Academic Press
Release Date : 1996-11-26

Neuroprotective Agents And Cerebral Ischaemia written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-26 with Science categories.


Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes. Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs. Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs Discusses the application of preclinical data to formulate approaches to a clinical problem Provides detailed reviews of both completed clinical trials and those currently underway



Advances In Neuroprotective Agents For Cerebral Ischemia Treatment


Advances In Neuroprotective Agents For Cerebral Ischemia Treatment
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Author : Yongjun Sun
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-20

Advances In Neuroprotective Agents For Cerebral Ischemia Treatment written by Yongjun Sun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-20 with Science categories.




The Handbook Of Neuroprotection


The Handbook Of Neuroprotection
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Author : Kewal K. Jain
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-14

The Handbook Of Neuroprotection written by Kewal K. Jain and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-14 with Medical categories.


Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative against the progression of the underlying disease, as well as regenerative. The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of neurological disorders. Neuroprotective effects of older, established drugs, as well as new drugs in development, are well documented in this detailed volume, featuring the most cutting-edge and innovative methods currently in use. In-depth and authoritative, The Handbook of Neuroprotection features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.



Emerging Strategies In Neuroprotection


Emerging Strategies In Neuroprotection
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Author : Manangos
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21

Emerging Strategies In Neuroprotection written by Manangos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.


SOLOMON H. SNYDER Receptor Research Reaches Neurology: Relevance to Neurodegenerative Diseases and Stroke President George Bush has heralded the 1990s as the decade of the brain, based largely on the rapid escalation of advances in the molecular neuro sciences and the likelihood that these will bear therapeutic fruit before the turn of the century. There is little doubt that the 1970s and 1980s have witnessed more remarkable advances in the molecular neurosciences than all of the preceding hundred years. Identification of receptor sites for drugs and neurotransmitters along with simple, sensitive, and specific means of monitoring them has made it possible to elucidate the mechanism of action for many known drugs and to identify new chemical entities as potential therapeutic agents. At the same time, the numbers of distinct neurotrans mitters have multiplied. Prior to 1970 only the biogenic amines were well accepted as transmitters. The early 1970s witnessed the gradual acceptance of amino acids as major excitatory and inhibitory neurotransmitters. Identification of opiate receptors and the subsequent identification of the enkephalins as their endogenous ligands led to an appreciation of peptides as putative transmitters and the accumulation of as many as a hundred neuropeptides by the decade's end. In the 1980s the revolutions of molecular biology have been applied aggressively to the neurosciences with molecular cloning for neuropeptide precursors, many important neurochemical en zymes, and receptors for numerous transmitters.



Therapeutic Agents And Targets To Minimize Ischemic Brain Injury


Therapeutic Agents And Targets To Minimize Ischemic Brain Injury
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Author : Bruno Meloni
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-30

Therapeutic Agents And Targets To Minimize Ischemic Brain Injury written by Bruno Meloni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.


BM would like to declare that he has filed patents for the application of arginine-rich peptide as neuroprotective agents for stroke and other neurological disorders. RRR patents licensed by Neuronasal Inc., a company that he also consults for and has equity interest in. All other Topic Editors declare no competing interests with regards to the Research Topic subject.



Neuroprotective Agents


Neuroprotective Agents
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Author : Bruce Trembly
language : en
Publisher:
Release Date : 1995

Neuroprotective Agents written by Bruce Trembly and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Lake George, NY categories.


This volume describes the use of both short- and long-term treatment of such neuroprotective agents as calcium channel antagonists, adenosine, cannabinoids, and NMDA receptor antagonists in cerebral ischaemia, hypoxia, head trauma, and neurotrauma, among other pathologic conditions. Further study is made of reactive oxygen species in neuronal degeneration and free radical mechanisms and neuroprotective antioxidants.



Neuroprotective Agents


Neuroprotective Agents
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Author : William Slikker
language : en
Publisher:
Release Date : 2001

Neuroprotective Agents written by William Slikker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.


An international group of scientists in both clinical and basic research in neuroprotective agents examine the effects of and therapy for spinal cord injury; inflammatory responses in intracerebral hemorrhage; neurotoxicity and genetic damage from amphetamine abuse; effects of marijuana abuse; cerebrovascular deficits; effects of and therapy for ischemic stroke; distribution of microglia in ageing brain and after transgenic manipulation; preconditioning gene induction for neuroprotection against oxidative stress; interaction of genes and environment in the expression and treatment of autism in an animal model; pathology and pharmacology of spreading depression. The volume also examines proposed designs and strategies for neuroprotection trials.



Oxford Textbook Of Neuroscience And Anaesthesiology


Oxford Textbook Of Neuroscience And Anaesthesiology
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Author : George A. Mashour
language : en
Publisher: Oxford University Press
Release Date : 2019-01-10

Oxford Textbook Of Neuroscience And Anaesthesiology written by George A. Mashour and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-10 with Medical categories.


The perioperative care of individuals with neurologic compromise is critically important, yet it is only one dimension of the rich relationship between anaesthesiology and the neurosciences. The mechanism of everyday therapeutic interventions such as anaesthesia and analgesia is exciting neuroscience in its own right. At the new frontier of outcomes studies lies the question of how the perioperative period might impact the brain. For example, questions related to anaesthetic neurotoxicity, delirium, and cognitive dysfunction pose critical challenges for the field. The Oxford Textbook in Neuroscience and Anaesthesiology addresses the exciting field of neuroanaesthesiology in a new and stimulating way. In twenty eight chapters, the neuroscientific basis of anaesthesiology, the full spectrum of clinical neuroanaesthesia, and the care of neurologic patients undergoing non-neurologic surgery are explored in one comprehensive textbook for the first time. The first section considers the neural mechanisms of general anaesthetics, cerebral physiology, the neurobiology of pain, and more. The second section explores the care of patients with neurologic disease in the operating room or intensive care unit. These clinical chapters systematically treat the perioperative considerations of both brain and spine surgery, and provide introductions to neurocritical care and pediatric neuroanaesthesia. The final section outlines the care of neurologic patients undergoing non-neurologic surgery. It examines key connections of neurology and anaesthesiology, examining how conditions such as dementia, stroke, or epilepsy interface with the perioperative period. Each chapter has been carefully crafted to be concise yet highly informative, reflecting the cutting edge of neuroscience and neuroanaesthesiology. This international textbook gathers the best available expertise of authors and leaders worldwide. Includes access to online-only content, including more than 20 cases and more than 90 questions that can be used in presentations and teaching sessions. By activating your unique access code, you can access and use the material.



Neuroprotective Therapy For Stroke And Ischemic Disease


Neuroprotective Therapy For Stroke And Ischemic Disease
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Author : Paul A. Lapchak
language : en
Publisher: Springer
Release Date : 2017-01-12

Neuroprotective Therapy For Stroke And Ischemic Disease written by Paul A. Lapchak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-12 with Medical categories.


A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.



Neuroprotection In Brain Hypoxia


Neuroprotection In Brain Hypoxia
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Author : Matilde Otero-Losada
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-30

Neuroprotection In Brain Hypoxia written by Matilde Otero-Losada and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.


Despite compelling preclinical evidence from laboratory models of brain hypoxia suggesting potential neuroprotective strategies, only scattered data are available from clinical studies. A few candidate neuroprotectants have been studied regarding antioxidant, antiapoptotic, anti-excitotoxic, immunomodulatory, and neurotrophic effects. In parallel with clinical innovations, preclinical research initiatives are also identifying new animal models more closely resembling the clinical course and pathology of neurodegenerative diseases. Clarifying the specific mission of the brain cells involved in the damage/repair system in the examined animal models is important to define new therapeutic targets. Following hypoxic damage, detrimental events intermingle with the repairing events in both time- and cellular-dependent fashion. Identifying reliable post-hypoxia brain markers is mandatory to develop potential therapeutic interventions, improving translational research from the experimental observations to the clinical application. A deeper understanding of the precise participation of neurons, glia, and endothelial cells is expected to offer more clues for designing new therapeutic strategies to reduce the current gap among the experimental and the clinical data. One of the main issues should be to study the epigenetic mechanism of neuroprotective agents and their action on the genetic modification induced by hypoxia. Achieving this goal is presumed critical to obtain more conclusive results in patients that by now do not receive appropriate therapy for mitigating the several diseases generated by brain hypoxia. Although a few ongoing studies are evaluating interesting approaches, future research is necessary to come to a novel mechanism of neuroprotection. This book encompasses different chapters conveying the goals and aims of the pertaining research.